Preparation method of dual-ion collaboration crosslinking rapid self-healing type bacteriostasis hydrogel

Abstract

Disclosed is dual-ion collaboration crosslinking rapid self-healing type bacteriostasis hydrogel. The hydrogel is generated by chemical and physical crosslinking of polyvinyl alcohol and agar, the internal structure is a three-dimensional network structure, and metal ion of the network structure are combinations of two of Fe3+, Al3+, Zn2+, Ca2+ and Cu2+; a preparation method of the bacteriostasishydrogel comprises the steps that agar and polyvinyl alcohol are dissolved into deionized water under the temperature of 95 DEG C, and then, acrylic acid is added into the mixture; nitrogen is introduced into the mixture for deoxygenation for 10 min, persulfate, N,N-methylene bisacrylamide and inorganic metal salt are added, the obtained solution is injected into a cylindrical model and kept at the temperature of 60-90 DEG C, the temperature is kept constant for 6-10 h, cooling is performed to reach the temperature of 2-5 DEG C, the temperature is kept constant for 1-5 h, the mixture is frozenat the temperature of subzero 20-subzero 15 DEG C, the temperature is kept constant for 2-5 h, the mixture is taken out to be unfrozen under the room temperature for 5-10 h, the freezing/defreezing processes are repeatedly executed 2-4 times, then, the mixture is taken out from the mold, and the hydrogel is obtained. The hydrogel has the high mechanical performance, rapid self-healing performanceand antibacterial performance.

Description

technical field [0001] The invention belongs to the field of material technology, in particular to a preparation method of a hydrogel material. Background technique [0002] In recent years, hydrogels have attracted much attention in superabsorbents, sensors, tissue engineering scaffolds, and drug carriers due to their good softness, sensitivity, biocompatibility, and permeability. However, most traditional hydrogels have a single network structure and uneven internal structure, which makes their mechanical strength, tensile properties and toughness poor, which severely limits the application of hydrogels in markets that require high mechanical strength. With the improvement of the performance requirements of hydrogels, hydrogels with new toughening mechanisms and mechanical strength of microstructures began to be produced, such as double network hydrogels, nanocomposite hydrogels, polyampholyte hydrogels, Hydrophobically modified hydrogels, etc. Among them, the double net...

AI Technical Summary

Problems solved by technology

And most conventional hydrogels do not exhibit more than two characteristics at the same time, for example, they have excellent self-healing properties but poor mechanical properties

However, some hydrogels with good mechanical properties still have some disadvantages in terms of self-healing ability, including: 1) the healing process occurs in a non-autonomous manner and usually requires harsh healing conditions such as high temperature, pH, etc.; 2) the healing is not complete. , which means that the mechanical properties of the healed samples are usually lower than those of the pristine samples; 3) Some uncertainties in the healing process and the biocompatibility of the polymers used to make hydrogel devices still exist, so there is an urgent need to Developing a new strategy to improve the mechanical strength and self-healing properties of hydrogels and enhance self-healing properties