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A kind of preparation method of antibacterial polypeptide modified polyurethane nano film

A technology of antibacterial polypeptide and nano-film, which is applied in the field of preparation of anti-bacterial polypeptide-modified polyurethane nano-film, which can solve few problems such as bacterial infection, difficult human tissue modulus, wound heating, etc., and achieve good mechanical properties and adhesion effect Good, easy to use and comfortable effect

Active Publication Date: 2020-02-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cyanoacrylate bioglue is brittle after curing, it is difficult to match the modulus of human tissue, it will cause wound heating when used, and the degradation products have cytotoxicity and other shortcomings, which also limit its wide application.
[0004] Moreover, most of the traditional repair methods only close and stop bleeding after wound debridement, and seldom consider a series of problems caused by subsequent bacterial infections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Preparation of polyurethane resin modified by antibacterial polypeptide

[0020] 1.1) 10g (-OH of 120mmol) of hydroxyl-terminated hyperbranched polyester H101 and 4.76ml (60mmol) of acryloyl chloride are fed according to the molar ratio of functional groups, and react to obtain a hyperbranched polyester containing double bond-terminated hydroxyl;

[0021] 1.2) get 0.662g (-OH of 3mmol) step 1.1) to obtain the hyperbranched polyester containing double bond terminal hydroxyl and 1.356 (-NCO of 6mmol) LDI, pass N 2 Protection, reaction at 30°C to obtain a polyurethane prepolymer containing isocyanate (-NCO) groups; then add 0.6g (3mmol of -OH) chain extender PEG200 to react to obtain a double bond-containing polyurethane resin;

[0022] 1.3) Carry out grafting reaction under the catalysis of dimethylphenylphosphine (DMPPh) containing double bond polyurethane and 0.05wt% antibacterial polypeptide Tet213 containing mercapto group (-SH) in step 1.2) to obtain desired antib...

Embodiment 2

[0025] 1) Preparation of polyurethane resin modified by antibacterial polypeptide

[0026] 1.1) 12g (-OH of 120mmol) of hydroxyl-terminated hyperbranched polyester H201 and 4.76ml (60mmol) of acryloyl chloride are fed according to the molar ratio of functional groups, and react to obtain a double-bonded hydroxyl-terminated hyperbranched polyester;

[0027] 1.2) get 0.762g (-OH of 3mmol) step 1.1) to obtain the hyperbranched polyester containing double bond terminal hydroxyl and 1.5g (-NCO) MDI of 6mmol, pass N 2 Protection, reaction at 30°C to obtain a polyurethane prepolymer containing isocyanate (-NCO) groups; then add 0.33g (1.515mmol of -OH) chain extender PEG200 to react to obtain a double bond-containing polyurethane resin;

[0028] 1.3) Carry out grafting reaction under the catalysis of dimethylphenylphosphine (DMPPh) containing double bond polyurethane and 0.05wt% antibacterial polypeptide Tet213 containing mercapto group (-SH) in step 1.2) to obtain desired antibacter...

Embodiment 3

[0031] 1) Preparation of polyurethane resin modified by antibacterial polypeptide

[0032] 1.1) 18.4g (-OH of 120mmol) of hydroxyl-terminated hyperbranched polyester H301 and 4.76ml (60mmol) of acryloyl chloride are fed according to the molar ratio of functional groups, and react to obtain a hyperbranched polyester containing double bond-terminated hydroxyl;

[0033] 1.2) Get 1.062g (-OH of 3mmol) step 1.1) to obtain the hyperbranched polyester containing double bond terminal hydroxyl and 1.5g (-NCO) MDI of 6mmol, pass N 2 Protection, reaction at 30°C to obtain a polyurethane prepolymer containing isocyanate (-NCO) groups; then add 0.99g (1.515mmol of -OH) chain extender PEG600 to react to obtain a double bond-containing polyurethane resin;

[0034] 1.3) Carry out grafting reaction under the catalysis of dimethylphenylphosphine (DMPPh) containing double bond polyurethane and 0.05wt% antibacterial polypeptide Tet213 containing mercapto group (-SH) in step 1.2) to obtain desired...

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PUM

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Abstract

The invention discloses a preparation method of an antibacterial polypeptide modification polyurethane nanometer film. The method comprises the following steps of (1) preparing antibacterial polypeptide modification polyurethane resin; (2) dissolving the polyurethane resin obtained in the step (1) into a proper solvent; obtaining a nanometer film by a rotary coating method; next, after UV photocuring, performing drying to remove solvents; finally obtaining the required antibacterial polypeptide modification polyurethane nanometer film, wherein the solvent is prepared from one or several kindsof materials from tetrahydrofuran, methanol, ethanol, propanol and water. The antibacterial polypeptide modification polyurethane nanometer film prepared by the method has good biosecurity; the use isconvenient and comfortable; the antibacterial polypeptide modification polyurethane nanometer film can be physically adhered onto tissues with different appearances; the antibacterial effect is good;bacterium resistance cannot be generated.

Description

technical field [0001] The invention relates to the technical field of medical tapes, in particular to a method for preparing an antibacterial polypeptide-modified polyurethane nano film. Background technique [0002] Given the huge market and continuous demand, the research and development of soft tissue repair materials has always been a hot spot in the field of biomedical materials. Traditional soft tissue wound repair materials mainly include medical tapes, sutures and biological glues, which have been making important contributions to human survival and health since their invention. [0003] Medical tape mainly includes gauze, Band-Aid, etc., which are the cheapest, most convenient and most widely used wound dressing materials. However, when dealing with complex wounds, the sealing effect is slightly weak. Surgical sutures have high closure strength to wounds, and recently degradable surgical sutures have been developed one after another, without the need for postoper...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/76C08G18/73C08G18/68C08G18/64C08G18/10
CPCC08G18/10C08G18/6453C08G18/68C08G18/73C08G18/7671C08G18/64
Inventor 施雪涛宣承楷
Owner SOUTH CHINA UNIV OF TECH