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A kind of sponge material and its preparation method and application

A sponge and cross-linking reaction technology, applied in bandages, medical science, etc., can solve the problems of difficulty in maintaining the cross-linking reaction of polyvinyl alcohol and chitosan, difficulty in reflecting the treatment effect of the affected area, and hindering the smooth progress of the foaming process, etc., to achieve Excellent therapeutic effect, high water absorption, high porosity effect

Active Publication Date: 2021-03-12
BEIJING YINGJIA MEDICAL MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In related technologies, polyvinyl alcohol solution and chitosan solution are mostly used for homogeneous crosslinking reaction, but in this case, chitosan can only be added in a very low amount, and the addition of a large amount of chitosan will significantly Increasing the viscosity of the reaction system hinders the smooth progress of the foaming process. At the same time, increasing the proportion of chitosan also makes it difficult to maintain the crosslinking reaction between polyvinyl alcohol and chitosan in a homogeneous system.
Adopt the method of related technology, if increase the consumption of chitosan, will cause a large amount of chitosan not to participate in the cross-linking reaction, the product after curing is in actual use, the chitosan that does not participate in the cross-linking reaction will be Very easy to fall off directly or block the foaming channel
Under the situation that the dosage of chitosan is limited in the related art, the obtained product is difficult to reflect the therapeutic effect to the affected part again

Method used

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  • A kind of sponge material and its preparation method and application
  • A kind of sponge material and its preparation method and application

Examples

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Effect test

preparation example Construction

[0047] The specific embodiment of the present invention provides a kind of preparation method of sponge material, comprising:

[0048] Add catalyst and cross-linking agent into the polyvinyl alcohol solution, stir for cross-linking reaction and foaming, add chitosan solid, continue stirring for cross-linking reaction and foaming, and solidify to obtain a sponge material.

[0049] Both polyvinyl alcohol and chitosan contain hydroxyl groups in their molecular chains, and both have the ability to undergo condensation reactions with crosslinking agents. When solid powdered chitosan is added to the polyvinyl alcohol foaming system, it also dissolves on the surface of its particles, and the local microscopic dissolution and crosslinking agent undergo a homogeneous crosslinking reaction, so that the polyvinyl alcohol and chitosan macroscopically Mixed foaming is possible.

[0050] Chitosan powder is added during the foaming process of polyvinyl alcohol. When the foaming is completed...

Embodiment 1

[0097] A preparation method of a sponge material, comprising:

[0098] a. Polyvinyl alcohol (polymerization degree is 400; alcoholysis degree is 88%) is dissolved in water at 70° C. and a stirring speed of 200 rpm, and a polyvinyl alcohol aqueous solution having a mass concentration of 10% is prepared;

[0099] b. Add dilute H to polyvinyl alcohol solution 2 SO 4 Aqueous solution (mass fraction is 36%, H 2 SO 4 The consumption is 7% of polyvinyl alcohol solution and chitosan solid gross mass) and formaldehyde (consumption is 60% of polyvinyl alcohol solution and chitosan solid gross mass), at 65 ℃, under the stirring speed of 1000rpm, carry out Cross-linking reaction and foaming for 60 minutes;

[0100] c. add chitosan (molecular weight is 10 2 ; degree of deacetylation is 50%) solid (particle diameter is 80 orders, the mass ratio of polyvinyl alcohol and chitosan solid is 1:0.1), at 65 ℃, under the stirring speed of 1000rpm, continue to stir and carry out cross-linking r...

Embodiment 2

[0103] A preparation method of a sponge material, comprising:

[0104] a. Polyvinyl alcohol (polymerization degree is 2600; alcoholysis degree is 99%) is dissolved in water at 95° C. and a stirring speed of 50 rpm, and a polyvinyl alcohol aqueous solution having a mass concentration of 40% is prepared;

[0105] b. Add dilute H to polyvinyl alcohol solution 2 SO 4 Aqueous solution (mass fraction is 36%, H 2 SO 4 The consumption is 3% of polyvinyl alcohol solution and chitosan solid gross mass) and formaldehyde (consumption is 20% of polyvinyl alcohol solution and chitosan solid gross mass), at 20 ℃, under the stirring velocity of 200rpm, carry out Cross-linking reaction and foaming for 20 minutes;

[0106] c. add chitosan (molecular weight is 10 6 ; degree of deacetylation is 95%) solid (particle diameter is 140 orders, the mass ratio of polyvinyl alcohol and chitosan solid is 1:0.4), at 20 ℃, under the stirring speed of 200rpm, continue to stir and carry out cross-linking...

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Abstract

The invention provides a sponge material as well as a preparation method and application thereof. The preparation method of the sponge material has a simple process; the specific addition reaction sequence is used; after the polyvinyl alcohol crosslinking to a certain degree, chitosan solids are added for further reaction; the consumption proportion of the chitosan can be obviously improved; the chitosan can sufficiently take part in the crosslinking reaction; the condition of excessive chitosan falling in the obtained sponge material cannot be caused; the comprehensive performance such as porosity, water absorption rate, moisture preservation rate and ventilation rate of the obtained sponge material can be sufficiently ensured; meanwhile, the obtained sponge material can achieve an excellent treatment effect on the affected part. The sponge material has high chitosan content ratio, high porosity, high water absorption rate, high moisture preservation rate, high ventilation rate and excellent comprehensive performance. The sponge material can be used as medical dressing; the excellent treatment effect can be achieved on the affected part.

Description

technical field [0001] The invention relates to the technical field of polymer foaming materials, in particular to a sponge material and its preparation method and application. Background technique [0002] In recent years, many materials and treatment methods have been invented for the treatment of trauma, among which the vacuum sealing drainage treatment technology has been widely recognized and used. The core material of this treatment method, polyvinyl alcohol sponge (PVA FOAM, PVF or polyvinyl alcohol foam), has good strength, elasticity, softness and biocompatibility. Under negative pressure, it exerts uniform pressure on the wound surface and plays a role in hemostasis. The negative pressure makes the secretion of the wound surface drained into the collection bottle through the open pore structure of the sponge, thus playing the role of cleaning the wound surface. This treatment method reduces the number of dressing changes, accelerates wound healing, and reduces pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L29/04C08L5/08C08J9/08A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/0085A61L2300/232A61L2300/412C08J9/08C08J2203/02C08J2329/04C08J2405/08C08L5/08C08L29/04
Inventor 朱铁桥
Owner BEIJING YINGJIA MEDICAL MATERIAL CO LTD
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