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Pharmaceutical composition for treating epileptiform convulsion, febrile convulsion and facial spasm and preparation method thereof

A technology for pediatric convulsion and hemifacial spasm, which is applied to a pharmaceutical composition for hemifacial spasm and its preparation. The drug is Xianyu Capsule, which can treat epilepsy convulsions and pediatric convulsions, and can solve frequent shutdowns for cleaning and capsule contents moisture absorption , accumulation and other problems, to achieve the effect of saving production costs and improving production efficiency

Active Publication Date: 2018-08-21
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In production practice, it was found that according to the above preparation method, there were fine particles of hygroscopic and sticky powder punches in the process of filling capsules after granulation, resulting in differences in filling capacity and frequent shutdowns for cleaning; Problems such as moisture absorption and accumulation of capsule contents

Method used

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  • Pharmaceutical composition for treating epileptiform convulsion, febrile convulsion and facial spasm and preparation method thereof
  • Pharmaceutical composition for treating epileptiform convulsion, febrile convulsion and facial spasm and preparation method thereof
  • Pharmaceutical composition for treating epileptiform convulsion, febrile convulsion and facial spasm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of medicinal material extract

[0029] The medicinal material extract of this embodiment is prepared by the following steps:

[0030] 1. Take Astragalus 1400g (here, 1 part by weight = 10g, the same below), Codonopsis 1400g, Salvia 1400g, Bupleurum 700g, Jujube seed 1050g, Polygala 700g, Gastrodia 1050g, Uncaria 1050g, Shichangpu 700g, Dannanxing 700g , Angelica 1400g, Stiff silkworm 1050g, Liushenqu 700g, Turmeric 700g, Licorice 700g, White Aconite 350g.

[0031] 2. Crush the dead silkworm and Liushenqu into fine powder, pass through a 80-100 mesh sieve, and set aside;

[0032] 3. Take the remaining fourteen medicinal materials such as Astragalus and decoct with water for three times, add 10 times the amount of water for the first time and cook for 2 hours, add 8 times the amount of water for the second time and cook for 1.5 hours, and add 6 times the amount of water for the third time 1 After hours, combine the decoction, filter, and concentrate the fil...

Embodiment 2

[0033] The screening test of the types of excipients in the pharmaceutical composition described in Example 2

[0034] Take 50g of the drug extract prepared in Example 1 and divide it into 6 parts equally, and add the same weight (5g) of soluble starch, microcrystalline cellulose, calcium carbonate, dicalcium phosphate, lactose, and technical powder (stiff silkworm and Liushenqu Mix according to the ratio of 10.5:7, pulverize, sieving), and write them as 1# (soluble starch), 2# (microcrystalline cellulose), 3# (calcium carbonate), 4# (calcium hydrogen phosphate), 5# (Lactose), 6# (original powder), mix evenly, respectively weigh 2g accurately and spread them in a flat weighing bottle dried to constant weight, and then place it in a glass desiccator with a sodium chloride supersaturated solution at the bottom , Weigh accurately at 0, 4, 8, 12, 24, 36, 48, 72, 96h; make 3 copies of each auxiliary material in parallel, calculate the moisture absorption percentage% according to formu...

Embodiment 3

[0040] Example 3 Screening test of the proportion of auxiliary materials

[0041] Take 8 parts of the drug extract prepared in Example 1 (40g each), add calcium carbonate and / or dibasic calcium phosphate in different weight ratios as shown in Table 2, and mix them evenly. Weigh 2g each and spread it evenly until it is dried. In a heavy flat weighing bottle, prevent it from being placed in a glass desiccator with a sodium chloride supersaturated solution at the bottom for 24h, take it out, and weigh again accurately; make 3 parts of each proportion of auxiliary materials in parallel, and calculate the moisture absorption percentage% according to formula A , Take the mean. The results are shown in Table 2.

[0042] Table 2 Screening test results of auxiliary material ratio / amount

[0043]

[0044] a : The ratio refers to the weight percentage of the drug extract.

[0045] The results in Table 2 show:

[0046] 1) The moisture absorption rate of the composition is obviously related to th...

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Abstract

The invention provides a pharmaceutical composition for treating epileptiform convulsion, febrile convulsion. The pharmaceutical composition comprises medical extract and auxiliary materials, whereinthe auxiliary materials are selected from one or two of calcium carbonate and calcium hydrophosphate; based on the weight of the medical extract, the weight fraction of the auxiliary materials is 10%;the medical extract is prepared by extracting the following traditional Chinese medicinal materials: astragalus, codonopsis pilosula, salviae miltiorrhizae, radix bupleuri, spina date seed, polygalatenuifolia, rhizoma gastrodiae, uncaria rhynchophylla, rhizoma acori graminei, arisaema cum bile, angelica sinensis, stiff silkworm, medicated leaven, radix curcumae, liquorice and giant typhonium rhizome. The pharmaceutical composition provided by the invention is uniform and smooth in flow, and when the composition is prepared into capsules, the adhesive powder punch pole condition is obviouslyimproved, so that the filling process is stabilized, the content uniformity range of the filled capsules is narrow, and the long-term stability of the capsules is excellent.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a pharmaceutical composition for treating epileptic convulsions, pediatric convulsions, and hemifacial spasm and a preparation method thereof. More specifically, the medicine is an Xianyu capsule. Background technique [0002] Epilepsy, also known as "horn wind", is a chronic brain disease characterized by a transient central nervous system dysfunction caused by abnormal discharge of brain neurons. According to the latest epidemiological data in China, the overall prevalence of epilepsy in China is 7.0‰, the annual incidence rate is 28.8 per 100,000, and the prevalence of active epilepsy with seizures within one year is 4.6‰. Based on this, it is estimated that there are about 9 million patients with epilepsy in China, of which 5-6 million are patients with active epilepsy. At the same time, there are about 400,000 new epilepsy patients every year. In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61P25/08A61P21/02A61K35/64
CPCA61K36/888A61K36/8884A61K36/8988A61K36/9066A61P21/02A61P25/08A61K9/1611A61K35/63A61K36/00A61K36/232A61K36/233A61K36/344A61K36/481A61K36/484A61K36/537A61K36/69A61K36/725A61K36/74A61K2236/51A61K2236/39A61K2236/331A61K2300/00
Inventor 吕慧锋胡小艳
Owner XIAN CHIHO PHARMA
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