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Tracheal catheter loaded with antimicrobial peptide MDC coating as well as preparation method and applications of tracheal catheter

A tracheal tube and antibacterial peptide technology are applied to the tracheal tube carrying antibacterial peptide MDC coating and the field of preparation thereof, so as to achieve the effects of improving the success rate of treatment, reducing the medical economic burden, and having significant antibacterial properties.

Inactive Publication Date: 2018-08-28
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no relevant report about using the antimicrobial peptide MDC as the antibacterial component of the biocoating for the preparation of endotracheal intubation catheters

Method used

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  • Tracheal catheter loaded with antimicrobial peptide MDC coating as well as preparation method and applications of tracheal catheter
  • Tracheal catheter loaded with antimicrobial peptide MDC coating as well as preparation method and applications of tracheal catheter
  • Tracheal catheter loaded with antimicrobial peptide MDC coating as well as preparation method and applications of tracheal catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 solid-phase chemical synthesis method synthetic antimicrobial peptide MDC

[0027] The amino acid sequence of the antimicrobial peptide MDC is: Ac-GWLKKI GKKIE RVGQH TRDAT IQTIG VAQQA ANVAATLKG-NH2, as shown in SEQ ID NO: 1, contains 40 amino acids, the theoretical isoelectric point is 10.56, and the theoretical molecular weight is 4299.04. The preparation of the antimicrobial peptide MDC is carried out one by one from the C-terminal to the N-terminal, and is completed by a peptide synthesizer. The specific steps are:

[0028] (1) First insert Fmoc-X (X is the first amino acid at the C-terminal of the antimicrobial peptide MDC) to Wang resin, and then remove the Fmoc group to obtain X-Wang resin; then Fmoc-Y-Trt-OH ( 9-fluorenylmethoxycarboxy-trimethyl-Y, Y is the second amino acid at the C-terminus of the antimicrobial peptide MDC); according to this procedure, it is synthesized from the C-terminus to the N-terminus until the synthesis is completed, and th...

Embodiment 2

[0033] Embodiment 2 carries the antimicrobial peptide MDC coating endotracheal tube preparation

[0034] (1) Dissolve medical chitosan in water for injection to make a gel solution with a mass volume concentration of 4%, and then add a certain amount of antimicrobial peptide solution to make the final concentration of antimicrobial peptide 0.2mg / mL, at 30°C Stir and mix at a speed of 300 rpm to prepare a coating film liquid, and use ultrasonic vibration for 20 minutes at room temperature to remove air bubbles in the coating film liquid, and obtain the antimicrobial peptide chitosan composite film liquid;

[0035] (2) Dip-coat or cast the antimicrobial peptide chitosan composite film solution prepared in step (1) on the PVC endotracheal tube substrate, dry naturally or cure and dry at 50°C, and obtain the antimicrobial peptide-loaded MDC coating endotracheal tube.

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Abstract

The invention belongs to the field of biomedical materials, and in particular relates to a tracheal catheter loaded with an antimicrobial peptide MDC coating as well as a preparation method and applications of the tracheal catheter. For the tracheal catheter, antimicrobial peptide MDC is adopted as the antibacterial agent, chitosan gel is adopted as the immobilization and slow release substrate, the antimicrobial coating is applied to the surface of the tracheal catheter, and then the tracheal catheter loaded with the antimicrobial peptide MDC coating is prepared. The sequence of the antimicrobial peptide MDC is as shown in SEQ ID NO:1. The tracheal catheter loaded with the antimicrobial peptide MDC coating provided by the invention has the remarkable antimicrobial property, and can effectively prevent bacterial colonization and growth. Therefore, after the tracheal catheter loaded with the antimicrobial peptide MDC coating provided by the invention is applied to the artificial tracheacannula and the breathing machine, the occurrence of trachea cannula and breathing machine associated pneumonia can be reduced or delayed, the economical burden of medical treatment is reduced, the physical and psychological pain of patients is alleviated, and the prospect is broad.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a tracheal tube carrying an antimicrobial peptide MDC coating and a preparation method and application thereof. Background technique [0002] Endotracheal intubation is a simple and effective way to establish an unobstructed airway in the rescue of critically ill patients. The artificial airway established by endotracheal intubation has become the most important "lifeline" for patients. In clinical practice, countless patients need tracheal intubation and mechanical ventilation every day, and implant-related infection among its complications has become an urgent problem for clinicians to solve. Ventilator-associated pneumonia, the most common and serious complication during mechanical ventilation, has high morbidity and mortality. Once it occurs and cannot be effectively controlled, patients will have to face extubation, reintubation or tracheal resection. Opening...

Claims

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Application Information

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IPC IPC(8): A61M16/04A61L29/08A61L29/16
CPCA61L29/08A61L29/16A61L2300/252A61L2300/404A61L2300/606A61M16/0402A61M2205/0205A61M2207/00C08L89/00A61L29/085A61M16/04A61M2205/0238C08L5/08
Inventor 卢雪梅桂水清张伦刘阿龙唐亚男陈朝霞金小宝朱家勇
Owner GUANGDONG PHARMA UNIV
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