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Determination method of alderone in cardamom

A determination method, the technology of alderone, which is applied in the field of determination of the content of alderone in cardamom, can solve the problems of unsuitable low content and content difference of alderone, inaccurate quantification, cumbersome operation, etc., and achieve the sample processing steps Simplicity, short analysis times, and effects over a large linear range

Inactive Publication Date: 2021-03-23
中国医科大学
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Problems solved by technology

[0007] At present, there are only reports in the literature and Chinese Pharmacopoeia on the qualitative identification and content determination of alderone in cardamom by TLC and HPLC. It is not suitable for the detection of medicinal materials with low content of alderone and large differences in content

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  • Determination method of alderone in cardamom
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  • Determination method of alderone in cardamom

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Embodiment 1

[0033] 1.1 Instruments, medicines and reagents.

[0034]Shimadzu QP2010 gas chromatography-mass spectrometry (Shimadzu Corporation); KQ-700E ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); rotary evaporator RE52-86A (Shanghai Yarong Biochemical Instrument Factory); traditional Chinese medicine pulverizer (Tianjin Test Instrument Co., Ltd.); electronic balance (200g / 0.1mg); NBS75K. mass spectrum database. Caffeine standard substance (National Institute for the Control of Pharmaceutical and Biological Products, product number: 171215, HPLC≥99%); alderone traditional Chinese medicine reference substance (Chengdu Desite Biotechnology Co., Ltd., LOT: DST170418-001, HPLC≥98%) ; 01 Cardamom Grass (purchased from Shenyang Guoda Pharmacy, Liaoning, identified by the Department of Pharmacognosy, School of Pharmacy, China Medical University); 02 Cardamom Grass (purchased from Qichuntang Pharmacy, Hebei, identified by the Department of Pharmacognosy, School of Pharmacy, Chin...

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Abstract

The invention belongs to the field of traditional Chinese medicine quality control and in particular relates to a method for determining content of alnusenone in alpinia katsumadai by adopting a GC / MS(Gas Chromatography-Mass Spectrometry). According to the GC / MS technology adopted in the invention, organic matters are separated by utilizing gas chromatography, and qualitative and quantitative analysis of to-be-determined matters can be completed by virtue of tandem mass spectrometry. Compared with the conventional analysis method, the method disclosed by the invention has the advantages of being high in selectivity, wide in linearity range, high in sensitivity, high in accuracy and precision, short in analysis time, simple in sample treatment steps and the like, is applicable to quality analysis of foods and drugs with great alnusenone content difference, can provide a brand new detection method for study on quality evaluation of alnusenone-containing foods and drugs and pharmacopoeiaimprovement of the alpinia katsumadai, and can also provide technical reference for in-vivo analytical study of the alnusenone.

Description

technical field [0001] The invention belongs to the field of quality control of traditional Chinese medicines, in particular to a method for determining the content of alderone in cardamom. Background technique [0002] Alpinia katsumadai Hayata (Alpinia katsumadai Hayata), also known as grass mulberry, cardamom, etc., is the dry and nearly mature seed of the Zingiberaceae (Zingiberaceae) Alpinia Roxburgh plant. It is mainly distributed in Hainan, Guangdong, Guangxi and Yunnan in my country. Warm and pungent, returns to the spleen and stomach meridians, has the effects of drying dampness and promoting qi, warming the middle and relieving vomiting; clinically used for cold-damp internal resistance, abdominal fullness and cold pain, belching and vomiting, and loss of appetite. The chemical components of cardamom are mainly volatile oils, flavonoids, diphenylheptanes, terpenes, polysaccharides and other components. Diphenylheptane compounds are a general term for compounds with...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 冯雪松王睿张雨佳
Owner 中国医科大学
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