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Composite type medical biological bone cement, preparation method and application thereof

A composite bone cement technology, applied in medical science, prosthesis, etc., can solve problems such as high elastic modulus of bone cement, nerve tissue damage, non-degradable absorption, etc., to inhibit bone resorption, promote new bone formation, and prepare Method quick and easy results

Active Publication Date: 2018-09-04
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, polymethylmethacrylate (PMMA) bone cement is widely used in clinic because of its good operability, biocompatibility, chemical stability and good mechanical properties, but polymethylmethacrylate (PMMA) ) bone cement has a single function, only relying on its mechanical strength to play a supporting role, and polymethyl methacrylate bone cement has a high elastic modulus, and it is not degradable and absorbable in the body. Damage to nerve tissue surrounding the injury site due to cement leakage

Method used

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  • Composite type medical biological bone cement, preparation method and application thereof
  • Composite type medical biological bone cement, preparation method and application thereof
  • Composite type medical biological bone cement, preparation method and application thereof

Examples

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Embodiment 1

[0023] A composite medical bio-bone cement, comprising a powder part and a liquid part with a weight ratio of 1:1, and the powder part, in parts by weight, comprises sodium alendronate-nano hydroxyapatite (ALN-HA ) powder 0.4g, polymethyl methacrylate powder (PMMA) 0.6g, dibenzoyl peroxide (BPO) 0.03g that the number average molecular weight is 500,000-700,000; Limestone powder (ALN-HA) was prepared as follows: Alendronate sodium (ALN) dissolved in ultrapure water was added to nano-hydroxyapatite (nHA), and the mixture of alendronate sodium and nano-hydroxyapatite The mass ratio is 0.01-0.2, stirred at 90°C for 5 hours, freeze-dried for 72 hours, and ground to obtain the target product. For its infrared spectrum, see figure 1 ; When the mass ratio of sodium alendronate and nano-hydroxyapatite is 0.2, that is, when the degree of modification of ALN in ALN-HA is 20%, the experimental thermogravimetric analysis results are as follows: figure 2 Shown; Described liquid portion co...

Embodiment 2

[0028] Referring to Example 1, the difference is that the weight ratio of the powder part to the liquid part is 1:1.5, 0.45 g of alendronate sodium-nanometer hydroxyapatite (ALN-HA) powder, and a number average molecular weight of 500,000-700,000 Polymethyl methacrylate powder (PMMA) 0.45g, dibenzoyl peroxide (BPO) 0.04g.

[0029] Compressive strength: According to the ISO5833 bone cement standard, a 12mm×6mm cylindrical specimen was prepared, and after curing at a constant temperature of 37°C for 24 hours, the compressive strength was measured with an AGS-10KN universal testing machine (AGS-10KN, Universal Testing Machines, Shimadzu, Japan) . The results show that the mechanical properties of the bone cement obtained by the present invention are up to the standard.

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Abstract

The invention discloses composite type medical biological bone cement. The composite type medical biological bone cement comprises a powder part and a liquid part in the mass ratio of (1: 1) to (1: 1.5); in parts by weight, the powder part comprises 40 to 45 parts of alendronate sodium-nano-hydroxyapatite powder, 45 to 60 parts of polymethyl methacrylate powder with the polymethyl methacrylate of0.5 to 0.7 million and 3 to 4 parts of dibenzoyl peroxide. The alendronate sodium-nano-hydroxyapatite powder is used for greatly improving the biocompatibility of PMMA bone cement, the mineralizationof the bone cement is promoted, the bone cement can be preferably combined with bone, the bone conduction effect and bone induction effect of the bone cement can be used for effectively promoting thegrowth of bone, simultaneously, the contained alendronate sodium is used for effectively resisting osteoporosis, the activity of osteoclasts is inhibited, and the bone absorption is reduced.

Description

Technical field: [0001] The invention relates to the technical field of biomaterials, in particular to a composite medical bio-bone cement and its preparation method and application. Background technique: [0002] At present, polymethylmethacrylate (PMMA) bone cement is widely used in clinic because of its good operability, biocompatibility, chemical stability and good mechanical properties, but polymethylmethacrylate (PMMA) ) bone cement has a single function, only relying on its mechanical strength to play a supporting role, and polymethyl methacrylate bone cement has a high elastic modulus, and it is not degradable and absorbable in the body. Cement leakage causes damage to the nerve tissue surrounding the injury site. Invention content: [0003] The purpose of the present invention is to provide a composite medical bio-bone cement, which can realize the function of self-expansion under the premise of reducing the total amount of bone cement, has better tissue compatib...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/58
CPCA61L27/46A61L27/58A61L2300/216A61L2300/412A61L2300/604C08L33/12
Inventor 熊柯张超谢妍蒋庆
Owner SUN YAT SEN UNIV
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