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Membrane type platy biological artificial liver reactor

A bio-artificial and reactor technology, applied in bioreactor/fermenter combinations, specific-purpose bioreactors/fermenters, biochemical instruments, etc. Stability and other issues, to achieve the effect of controllable density and uniform liver cells

Inactive Publication Date: 2018-09-04
CHONGQING UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a membrane-type plate-shaped bioartificial liver reactor, which is used to solve the defects of uneven distribution of liver cells carried by existing bioreactors, easy to fall off, and unstable material exchange efficiency

Method used

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  • Membrane type platy biological artificial liver reactor
  • Membrane type platy biological artificial liver reactor
  • Membrane type platy biological artificial liver reactor

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Embodiment Construction

[0030] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0031] Specific embodiments of the present invention will be described in more detail below. These embodiments are provided for a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0032] "Includes" or "comprises" mentioned throughout the specification and claims is an open term, so it should be interpreted as "including but not limited to". The subsequent description in the specification is a preferred implementation mode for implementing the present invention, but the description is for the purpose of the general principles of the specification, and is not intended to limit the scope of the present invention. The scope of protection of the present invention should be defined by the appended claims.

[0033] Such as figure 1 As shown, the membra...

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Abstract

The invention discloses a membrane type platy biological artificial liver reactor. The reactor comprises a tank, and a multilayer cell culture unit and a central cell suspension injection tube which are arranged in the tank, wherein in the multilayer cell culture unit, a cell culture membrane is circularly horizontally arranged, a scaffold is spoke-shaped or screen-shaped and has a central hole, the cell culture membrane is arranged on the upper side, and the scaffold is arranged on the lower side; the total height of the multilayer unit is about 2 / 3 of a cylindrical part of the tank. According to the membrane type platy biological artificial liver reactor designed in the invention, the cell culture membrane is horizontally favorable for liver cell adherence, a flow direction of plasma isperpendicular to the cell culture membrane, the cells difficultly drop, and the plasma and the cells can be fully contacted and can perform exchange of substances; due to the cell suspension injectionamount, the occupancy of membrane cells on each layer can be controlled, the plasma permeability is ensured, enough liver cells can be obtained by virtue of a multilayer plate structure, and a bioreactor in the conventional artificial liver support system is replaced.

Description

technical field [0001] The invention relates to the technical field of artificial liver reactors, in particular to a membrane-type plate-shaped bioartificial liver reactor. Background technique [0002] Artificial liver is a temporary or partial replacement of liver function by means of extracorporeal mechanical, chemical or biological devices, so as to assist in the treatment of liver insufficiency or related diseases. As an effective auxiliary treatment device for hepatic insufficiency, liver failure or related diseases, artificial liver has great potential in clinical application. [0003] According to the composition and properties of artificial liver, it can be divided into three categories: non-biological artificial liver, biological artificial liver, and hybrid artificial liver. The common methods of non-biological artificial liver treatment are hemodialysis, plasma or whole blood perfusion, blood replacement and filtration, etc., which can mainly realize the most ba...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/12C12M1/00
CPCC12M23/44C12M25/02C12M33/14
Inventor 王富平丁建强陈忠敏
Owner CHONGQING UNIV OF TECH
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