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Preparation method and application of temperature-responsive reversible hydrogel

A temperature-responsive, hydrogel technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc. Realize problems such as "sol-gel reversible transformation, and achieve the effect of simple and easy implementation, efficient loading, and wide sources.

Active Publication Date: 2020-08-04
CHINA UNIV OF PETROLEUM (EAST CHINA)
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the PNIPAM solution itself cannot form a hydrogel with the increase of temperature, let alone realize the reversible transformation of "sol-gel".
Peptide one-dimensional nanostructures have good biocompatibility and low toxicity due to their amino acid composition. This structure can provide surface groups or hydrophobic internal cavities to bind and load drug molecules, and is ideal for drug controlled release applications. ideal material, but it is not temperature responsive

Method used

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  • Preparation method and application of temperature-responsive reversible hydrogel
  • Preparation method and application of temperature-responsive reversible hydrogel
  • Preparation method and application of temperature-responsive reversible hydrogel

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[0027] An embodiment of the present invention provides a method for preparing a temperature-responsive reversible hydrogel, including:

[0028] S1: Prepare an aqueous solution of a polypeptide capable of self-assembling to form a one-dimensional nanostructure. The concentration of the polypeptide in the aqueous solution is greater than its self-assembly critical concentration, and place it to complete the self-assembly.

[0029] In this step, the self-assembled polypeptide self-assembles into a one-dimensional nanostructure. Due to its amino acid composition, it has good biocompatibility and low toxicity. This structure can also provide surface groups or hydrophobic internal cavities to bind drug molecules. and loading. In this step, peptides with strong assembly ability are self-assembled above a certain concentration to form long nanofibers, nanotubes and other assembly structures. It can be understood that the polypeptide molecules that can form one-dimensional nanostructure...

Embodiment

[0043] The preparation concentration is 10.0mM (greater than I 3 K critical self-assembly critical concentration) I 3 K aqueous solution, the pH of the aqueous solution is 4.5±0.5, and it is placed for more than 1 day to make it complete self-assembly, and the self-assembled nanofibrous structure is as follows figure 1 shown;

[0044] Poly-N-isopropylacrylamide (PNIPAM) was dissolved in Tris buffer solution at a concentration of 20 mg / mL, left overnight, and stirred to obtain a poly-N-isopropylacrylamide solution.

[0045] The above self-assembled I 3 K solution and the above poly-N-isopropylacrylamide solution were mixed in equal volumes at 30°C, stirred for 10 minutes, and mixed evenly to obtain a final solution. The concentration of the polypeptide in the final solution was greater than its self-assembly critical concentration while maintaining uniformity. Dispersion concentration, the concentration of poly-N-isopropylacrylamide in the final solution is greater than 1.0m...

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Abstract

The invention provides a preparation method and an application of a temperature-responsive reversible hydrogel, and belongs to the field of biological materials. The temperature-responsive reversiblehydrogel realizes reversible 'sol-gel' transformation along with temperature changes, can be used as a hydrogel dressing and an injection hydrogel, and simultaneously realizes loading and controlled release of different drugs. The preparation method of the temperature-responsive reversible hydrogel comprises the following steps: preparing an polypeptide aqueous solution capable of self-assemblingto form a one-dimensional nano-structure, wherein the concentration of the polypeptide in the solution is greater than a self-assembly critical concentration; standing the solution to complete self-assembly; dissolving poly(N-isopropylacrylamide) in a Tris buffer solution, carrying out standing overnight, and carrying out stirring to obtain a poly(N-isopropylacrylamide) solution; and mixing the self-assembled polypeptide solution and the poly(N-isopropylacrylamide) solution at 30 DEG C to obtain a final solution, thereby obtaining hydrogel when the temperature of the final solution is more than or equal to 32 DEG C.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a preparation method and application of a temperature-responsive reversible hydrogel. Background technique [0002] Smart hydrogels have the characteristics of responding to external environmental stimuli, and have important applications in functional "switch" materials, drug sustained-release materials, dressings, and injectable hydrogels, and are currently a research hotspot in the field of biomaterials. [0003] Among them, the temperature-sensitive hydrogel refers to the hydrogel whose system volume or phase behavior changes with temperature, and has unique advantages as a drug sustained-release material. For example, when the hydrogel is lower than the temperature of the human body, it can be in a shrinking state, which can realize the embedding of the drug well, but when it is in a swelling state at the temperature of the human body, the embedded drug molecules can freel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075A61L26/00A61K9/06A61K47/42A61K47/32A61K31/704A61P35/00C08L33/24
CPCA61K9/06A61K31/704A61K47/32A61K47/42A61L26/0014A61L26/0047A61L26/0066A61L26/008A61L2400/06A61P35/00C08J3/075C08J2333/24C08L33/24C08L89/00
Inventor 曹美文王瑜沈阳王生杰夏永清吕建仁
Owner CHINA UNIV OF PETROLEUM (EAST CHINA)
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