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Anti-cataract euphadienol preparation for eyes as well as preparation method and application thereof

A technology of euphanol and ophthalmic preparations, applied in the field of medicine, can solve problems such as cataracts and related ophthalmic diseases that have not been reported in the literature, achieve good prevention and treatment effects, improve permeability, and promote the effect of turbidity absorption

Active Publication Date: 2018-09-14
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] At present, there is no literature report on the use of eugenol to treat cataracts and related ophthalmic diseases.

Method used

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  • Anti-cataract euphadienol preparation for eyes as well as preparation method and application thereof
  • Anti-cataract euphadienol preparation for eyes as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0052] This embodiment provides an ophthalmic preparation for the prevention and treatment of cataract and related eye diseases, the ophthalmic preparation contains euphanol in a single or combined form.

[0053] Further, the ophthalmic preparation also contains a surfactant and a co-solvent with a pharmaceutical ophthalmic adjuvant, wherein the active ingredient is euphanol.

[0054] Further, the size of the nanoparticles of euphora is 20-100 nanometers.

[0055] Further, the concentration of eugenol in the ophthalmic preparation is 0.01-2.5% (weight / volume).

[0056] Further, said euphorbia can be natural euphorbia, also can be synthetic euphorbia; said natural euphorbia comes from various Euphorbiaceae natural medicines, such as glycerin Sui, Jing Euphorbia, etc.; the synthesis of euphorbia comes from chemical synthesis and biosynthesis.

[0057] Further, the surfactant is one or a mixture of Tween 80, Tween 20, polyethylene glycol ester, polyethylene glycol, lecithin and...

Embodiment 2

[0075] This embodiment is a preferred scheme based on Example 1. This embodiment provides a kind of eugenol nano-eye drops, and adopts thin film dispersion method to prepare eugenol nano-eye drops liposomes. Orthogonal method takes the encapsulation efficiency measurement results as the optimization index, and prepares the prescription as follows: 200 mg euphanol, 3000 mg lecithin, appropriate amount of absolute ethanol, phosphate buffered saline (PBS) (pH 7.0 ) 100 ml; dissolve the prescribed amount of euphanol and lecithin in absolute ethanol, rotate in vacuum at 40°C to form a thin film, and evaporate until there is no ethanol smell, add 100 ml of PBS (pH value 7.0) , hydration to obtain eugenol liposome suspension. The prepared euphora liposome particles were regular in shape, round or oval, 76.4% of the particles were distributed in the range of 110-200 nm in size, the average particle size was 145.2 nm, and the encapsulation efficiency was 90.02%. The prepared liposome ...

Embodiment 3

[0077]This embodiment is a preferred scheme based on Example 1. This embodiment provides a kind of euphadienol nano eye drops, which adopts thin film dispersion method to prepare euphadienol nano eye drops liposomes. Orthogonal method with encapsulation efficiency measurement results as the optimization index, the preparation of the prescription is as follows: eugenol 1000 mg, lecithin 15000 mg, appropriate amount of absolute ethanol, phosphate buffered saline (PBS) (pH 7.0 ) 500 ml; Dissolve the prescribed amount of euphorbia, lecithin, in absolute ethanol, rotate in vacuum at 40°C to form a thin film, and rotate to evaporate until there is no ethanol smell, add 500 ml of PBS (pH value 7.0) , hydration to obtain eugenol liposome suspension. The prepared euphorbia liposome particles were regular in shape, round or elliptical, 77.8% of them had a particle size distribution between 110 and 200 nm, the average particle size was 145.5 nm, and the encapsulation efficiency was 92.16...

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Abstract

The invention provides an anti-cataract euphadienol preparation for eyes as well as a preparation method and the application thereof. The anti-cataract euphadienol preparation contains euphadienol existing in an independent form or a combined form, and further contains a surfactant and a cosolvent having a medicinal eye adjuvant. The size of a nano particle of the euphadienol is 20 to 100 nm. Thepreparation for eyes has an extremely good treating effect on cataract, can be used for treating the cataract in different periods, is particularly applicable to patients suffering from primary senilecataract, mild diabetic cataract or concurrent cataract, and can improve the physiological functions of a human body, accelerate the blood circulation and nutrition metabolism of anterior segments, improve the permeability of a phacocyst, recover the physiological barrier effect, effectively control the turbidity of a crystalline lens and promote turbidity absorption.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an euphorpadienol anti-cataract ophthalmic preparation and a preparation method and application thereof. Background technique [0002] Cataract is the most important eye disease causing blindness, and 50% (1.7 million) of people blinded by cataract in the world. As people live longer and the population ages, the number of people blinded by cataracts will increase exponentially. At present, there are about 5 million cataract patients with binocular corrected vision of 0.3 in the country, and the cumulative increase of cataract patients is 400,000 to 1.2 million new cases every year. The prevalence of cataract in the elderly over 75 years old in China is as high as 91%, ranking first among the blinding eye diseases in my country. the first place. At present, cataract prevention and treatment in the world still takes surgery or implantation of intraocular lens as the main measur...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/575A61K47/24A61P27/12
Inventor 顾政一
Owner XINJIANG INST OF MATERIA MEDICA
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