Pharmaceutical composition of ornithine aspartate

A technology of ornithine aspartate and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-effective ingredients, etc., can solve the problems of high content of excipients, difficulty in taking medicine, complicated process, etc., and achieve small dosage , stable blood drug concentration, and simple preparation process

Inactive Publication Date: 2018-09-14
YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The marketed ornithine-aspartate preparation needs to be administered several times a day, which is inconvenient to use
Patent CN103705490A discloses a sustained-release preparation of ornithine aspartate to solve the problem, but its adjuvant content is high, and the oral administration dose of ornithine aspartate itself is relatively large (every 3g of granules) , adding more excipients is more likely to lead to difficulty in taking medicine; and blank ball cores are required to prepare drug-containing tablet cores, which is costly and complicated.

Method used

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  • Pharmaceutical composition of ornithine aspartate
  • Pharmaceutical composition of ornithine aspartate
  • Pharmaceutical composition of ornithine aspartate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] prescription:

[0020] Material composition

Prescription ratio (g)

Ornithine Aspartate

100

PLGA

30

PEG6000

10

[0021] Preparation:

[0022] 1) Mix PLGA with PEG 6000 and heat to 55°C; 2) Add ornithine aspartic acid to disperse evenly;

[0023] 3) Cool to 25°C and crush to obtain.

Embodiment 2

[0025] prescription:

[0026] Material composition

Prescription ratio (g)

Ornithine Aspartate

100

PLGA65:35

60

PEG6000

30

[0027] Preparation:

[0028] 1) Mix PLGA with PEG 6000 and heat to 38°C; 2) Add ornithine aspartic acid to disperse evenly;

[0029] 3) Cool to 30°C and crush to obtain.

Embodiment 3

[0031] prescription:

[0032] Material composition

Prescription ratio (g)

Ornithine Aspartate

100

PLGA50:50

50

PEG6000

15

[0033] Preparation:

[0034] 1) Mix PLGA with PEG 6000 and heat to 45°C; 2) Add ornithine aspartic acid to disperse evenly;

[0035] 3) Cool to 28°C and crush to obtain.

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PUM

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Abstract

The invention discloses a pharmaceutical composition of ornithine aspartate. By fusing, mixing and preparing ornithine aspartate and a proper amount of PLGA and PEG6000, the ideal slow-release effectcan be achieved. The pharmaceutical preparation prepared from the pharmaceutical composition of ornithine aspartate is slowly released, a patient just needs to take the medicine once a day, the patient compliance is high, the stable blood concentration can be maintained, the side effect is small, and the effect is good; the consumption of auxiliary materials is low, the preparation technology is simple, and the composition is suitable for technological production.

Description

technical field [0001] The invention relates to a pharmaceutical composition of ornithine aspartate. Background technique [0002] Ornithine aspartate can provide substrates for the synthesis of urea and glutamine. Glutamine is the detoxification product of ammonia, and it is also the storage and transportation form of ammonia; under physiological and pathological conditions, the synthesis of urea and glutamine Amide synthesis is affected by ornithine, aspartate, and other dicarboxylic compounds. Ornithine is almost involved in the whole process of urea cycle activation and ammonia detoxification. In the process, arginine is formed, which in turn splits off urea to form ornithine. Aspartic acid participates in the synthesis of nucleic acid in liver cells to facilitate the repair of damaged liver cells. In addition, due to the indirect promotion effect of aspartic acid on the metabolism process of tricarboxylic acid cycle in liver cells, the energy generation in liver cell...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/205A61K47/34A61K47/10A61P1/16A61P25/00
CPCA61K9/146A61K31/205A61P1/16A61P25/00
Inventor 钟艳红夏春森施猛任亚东刘志强欧志展张国文袁海成
Owner YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD
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