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Microcrystalline cellulose and guar gum compound pharmaceutic adjuvant and preparation method thereof

A technology for microcrystalline cellulose and pharmaceutical excipients, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, drug delivery, etc. Can not be made into tablet form and other problems, to achieve the effect of low cost, easy acceptance, and a wide range of sources

Inactive Publication Date: 2018-09-14
SHENZHEN YOUPUHUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many medicines cannot be made into tablet form due to lack of suitable excipients, which is not conducive to the convenience and rapid administration of consumers (especially children)
There is no report on the composite of microcrystalline cellulose and guar gum

Method used

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  • Microcrystalline cellulose and guar gum compound pharmaceutic adjuvant and preparation method thereof
  • Microcrystalline cellulose and guar gum compound pharmaceutic adjuvant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of the pharmaceutical excipient of microcrystalline cellulose and guar gum compound chewable tablet comprises the following steps:

[0039] Add 500 kg of medical deionized water, then add 12.5 kg of pharmaceutical grade guar gum dry product, use SWFS-400 type high-speed disperser to stir, and the stirring rate is 100 rpm;

[0040] After guar gum dissolves completely, add 100 kilograms of microcrystalline cellulose (water content is 45%, polymerization degree is less than 350, and pH is 6.0); Improve stirring to 450 rpm, continue to stir for 25 minutes;

[0041] Then the resulting mixture slurry is dried with a spray drying tower, and the air inlet temperature is set to 200°C, the outlet air temperature is 130°C, the atomization speed is 50HZ, the feed flow rate is 0.5 cubic meters per hour, and the negative pressure is 300 Pa , dried, and the obtained solid powder was sieved to have a particle size d50 of 200 microns. The particle size was detecte...

Embodiment 2

[0043] The preparation method of the pharmaceutical excipient of microcrystalline cellulose and guar gum compound chewable tablet comprises the following steps:

[0044] Add 500 kg of medical deionized water, then add 12.5 kg of pharmaceutical grade guar gum dry product, use SWFS-400 type high-speed disperser to stir, and the stirring rate is 100 rpm;

[0045]After guar gum dissolves completely, add 130 kilograms of microcrystalline cellulose (water content is 45%, degree of polymerization is less than 350, and pH is 6.0); Improve stirring to 500 rpm, continue to stir for 30 minutes;

[0046] Then the resulting mixture slurry is dried with a mist drying tower, and the air inlet temperature is set to 220°C, the outlet air temperature is 150°C, the atomization speed is 60HZ, the feed flow rate is 0.3 cubic meters per hour, and the negative pressure is 300 Pa , dried, and the obtained solid powder was sieved into a particle size d50 of 200 microns, and the particle size was detec...

Embodiment 3

[0048] The preparation method of the pharmaceutical excipient of microcrystalline cellulose and guar gum compound chewable tablet comprises the following steps:

[0049] Add 500 kilograms of medical deionized water, then add 20 kilograms of dried guar gum of pharmaceutical grade, and stir with a SWFS-400 high-speed disperser at a stirring rate of 150 rpm;

[0050] After guar gum dissolves completely, add 100 kilograms of microcrystalline cellulose (water content is 45%, degree of polymerization is less than 350, and pH is 6.0); Improve stirring to 500 rpm, continue stirring for 30 minutes;

[0051] Then the resulting mixture slurry is dried with a spray drying tower, and the air inlet temperature is set to 250°C, the outlet air temperature is 150°C, the atomization speed is 80HZ, the feed flow rate is 0.2 cubic meters per hour, and the negative pressure is 300 Pa , dried, and the obtained solid powder was sieved into a particle size d50 of 200 microns, and the particle size wa...

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Abstract

The invention provides a microcrystalline cellulose and guar gum compound pharmaceutic adjuvant and a preparation method thereof. The mass ratio of guar gum to microcrystalline cellulose in the pharmaceutic adjuvant is 1:(4.0-11.5). The preparation method comprises the steps that the guar gum and water are taken and mixed at first stirring speed until the guar gum is completely dissolved, and a guar gum solution is prepared; the microcrystalline cellulose is added into the guar gum solution, and the materials are mixed and stirred at second stirring speed; the obtained mixture is dried, and the pharmaceutic adjuvant is prepared. A microcrystalline cellulose and guar gum compound is adopted as the pharmaceutic adjuvant and applied to chewable tablets, the problems of the sand feeling, the sticky feeling, the chalk feeling and the like can be solved, an eater can feel the smooth taste of creaminess after taking the tablets, and therefore the good overall taste of a solid preparation canbe felt. A patient, especially a child patient can accept the chewable tablets more easily.

Description

technical field [0001] The invention relates to the technical field of chemical preparations, in particular to a pharmaceutical excipient compounded with microcrystalline cellulose and guar gum and a preparation method thereof. Background technique [0002] Microcrystalline cellulose (MCC), also known as wood powder, microcrystalline, cellulose, etc., can be hydrolyzed by natural cellulose and dilute acid to produce white, odorless, tasteless microcrystalline cellulose solid. Usually in the form of free-flowing very fine short rods, or powdery porous particles. The solid particle size of microcrystalline cellulose is generally 20-80Lm, and the limiting degree of polymerization (LODP) is 15-375; it is not fibrous and has strong fluidity. Insoluble in water, dilute acids, organic solvents and oils, partially soluble and swelling in dilute alkali solutions, and has high reactivity in the process of carboxymethylation, acetylation and esterification. [0003] Because there are...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/36A61K9/20
CPCA61K9/0056A61K9/205A61K9/2054
Inventor 段民英李洪文刘巴宁杨登科
Owner SHENZHEN YOUPUHUI PHARM CO LTD
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