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Rabbit coccidiosis vaccine and application thereof

A rabbit coccidiosis and vaccine technology, applied in the field of rabbit coccidiosis vaccine and its application, can solve the problems of high economic cost, drug residue environment, and harm to human health, and achieve scientific and reasonable composition, good immunogenicity, and easy application safe effect

Pending Publication Date: 2018-10-09
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies in the above-mentioned prior art, the purpose of the present invention is to provide a rabbit coccidiosis vaccine and its application, aiming to solve the problem that rabbit coccidiosis in the prior art mainly relies on drug control, and drug control often causes rabbits Increased drug resistance of coccidia, drug residues, environmental pollution and harm to human health, and the problems of long research and development cycle, high risk and high economic cost of new drugs

Method used

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  • Rabbit coccidiosis vaccine and application thereof
  • Rabbit coccidiosis vaccine and application thereof
  • Rabbit coccidiosis vaccine and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] The preparation of embodiment 1 rabbit coccidiosis vaccine

[0024] Count the sporulated oocysts of Eimeria medium, Eimeria large, and Eimeria enterica separately with a hemocytometer to obtain their concentrations, and calculate the coccidia of each component according to the ratio in Table 1. The required volume and quantity of oocysts are put into the same clean container in turn, and the preservation solution is added and stirred to obtain a mixed strain oocyst solution with corresponding components.

[0025] Table 1 Composition ratio of rabbit coccidiosis vaccine

[0026]

Embodiment 2

[0028] Take 50 ordinary-grade rabbits with similar body condition and no coccidia from fecal examination at the age of 25 to 90 days, and divide them into 10 groups with 5 rabbits in each group. The ages of the rabbits in each group are evenly distributed. The third is the immune challenge group with ratio 1, the fourth, fifth and sixth groups are immune challenge groups with ratio 2, the seventh, eighth and ninth groups are non-immune challenge groups, and the tenth group is non-immune and non-challenge Insect group. The 10 groups were separately reared under the same conditions, and 14 days after oral administration of the corresponding proportion of vaccines, the rabbits in each group were weighed and challenged. Groups 1, 4, and 7 received 1×10 sporulated oocysts of Eimeria medulla by oral administration. 5 each; the second, fifth, and eighth groups were orally challenged with sporulated oocysts of Eimeria majora 5×10 4 One / piece; the third, sixth, and ninth groups were ...

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Abstract

The invention discloses a rabbit coccidiosis vaccine and application thereof. The rabbit coccidiosis vaccine comprises 100-800 pieces of medium eimeria, 200-1600 pieces of large eimeria and 100-800 pieces of eimeria intestinalis. The vaccine is scientific and reasonable in composition, low in cost, free of drug residue after use, drug tolerance and environment pollution, high in immunogenicity andsafe to use; after oral immunization, rabbits can effectively resist infection of 1x105 medium eimeria, 5x104 large eimeria and 3x103 eimeria intestinalis, and the vaccine can be applied in preparingdrug preparation for preventing rabbit coccidiosis.

Description

technical field [0001] The invention relates to the field of veterinary biological products and its application, in particular to a rabbit coccidiosis vaccine and its application. Background technique [0002] Rabbit coccidiosis is a parasitic disease caused by Eimeria genus Eimeria apicomplexa parasitizing in the small intestine or bile duct epithelial cells of rabbits. Currently, there are 11 species of Eimeria rabbits recognized in the world. insect. As long as there are places where rabbits are raised, there will be rabbit coccidiosis. Rabbit coccidiosis is listed as one of the second-class animal diseases in my country. All varieties of rabbits are susceptible to the disease. Among them, the infection and disease of young rabbits from weaning to 3 months old are the most serious, and the mortality rate is very high. Common multiple diseases in rabbit production. Sick rabbits often show symptoms such as lack of energy, malnutrition, slow growth, diarrhea, and even acut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/012A61P33/02
CPCA61K39/012A61K2039/542A61K2039/552A61P33/02A61K35/68A61K2039/52A61K2039/543C07K14/455
Inventor 谭志坚翁亚彪刘丽丹刘园王新秋曾莉黄仕凤黄仪娟欧瑶瑶
Owner FOSHAN STANDARD BIO TECH
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