Composition of callicarpa nudiflora and application in treatment of pharyngitis

A technology of violacea nudiflora and composition, which is applied in the directions of drug combinations, medical preparations containing active ingredients, plant raw materials, etc. Unclear and other problems, to achieve the effect of significant curative effect, stable quality, clear composition and content

Active Publication Date: 2018-10-23
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cui Huixin et al. ("Observation on the Clinical Curative Effect of Naked Flower Zizhu Tablets in the Treatment of Chronic Pharyngitis", "China Coal Industry Medical Journal", Volume 12, No. 4, April 2009) applied the nude flower Zizhu preparation to treat pharyngitis, and achieved good results , especially for chronic simple and hypertrophic pharyngitis, the treatment effect is remarkable and safe, but in the above-mentioned prior art, the dosage of related preparations of Nadihuazizhu is large, the active ingredients are not clear, the mechanism of treatment is not clear, and the controllability of quality standards is poor. and other shortcomings, it is difficult to meet the requirements of "safe, effective, controllable and stable" drugs

Method used

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  • Composition of callicarpa nudiflora and application in treatment of pharyngitis
  • Composition of callicarpa nudiflora and application in treatment of pharyngitis
  • Composition of callicarpa nudiflora and application in treatment of pharyngitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 The extraction of total flavonoids, total phenolic acids and phenylethanol glycosides

[0047] (1) Preparation of the water extract of Auranthus nudiflora:

[0048] Add water to 100°C and extract 3 times, add 8 times of water each time, extract for 2.5 hours for the first time, and extract for 0.5 hours for the second and third times, combine the filtrates, filter, and concentrate under reduced pressure at 60°C to a relative density of 1.30-1.35 In the form of extract, dried at 60°C to dry extract, set aside;

[0049] (2) Preparation of total flavonoids from Auranthus nudica:

[0050] ① Dissolve the water extract of Aurora nudiflora in ethanol, and prepare a 0.5mg / mL ethanol solution of Aurora nudiflora;

[0051] ②The ethanol solution of Auranthus nudica was passed through AB-8 resin (the ratio of diameter to height was 1:15), 95% ethanol was used as eluent, the injection rate was 1.5mL / min, the elution rate was 20 drops / min, and the eluate was collected. D...

Embodiment 2

[0061] Example 2 The extraction of total flavonoids, total phenolic acids and phenylethanol glycosides

[0062] (1) Preparation of the water extract of Auranthus nudiflora:

[0063] Add water 105°C to extract 2 times, each time add 10 times of water, extract for 2 hours for the first time, extract for 1 hour for the second time, combine the filtrate, filter, concentrate under reduced pressure at 80°C to an extract with a relative density of 1.30-1.35 , dried at 70°C to form a dry extract, and set aside;

[0064] (2) Preparation of total flavonoids from Auranthus nudica:

[0065] ①The water extract of Aurora nudiflorum, dissolved in ethanol, is prepared as 0.8mg / mL ethanol solution of Aurora nudiflora;

[0066] ②The ethanol solution of Aurantia nudica is passed through AB-8 resin (the ratio of diameter to height is 1:10), 90% ethanol is used as the eluent, the injection rate is 2mL / min, the elution rate is 25 drops / min, and the eluted After the total flavonoid content of the...

Embodiment 3

[0076] Example 3 The extraction of total flavonoids, total phenolic acids and phenylethanol glycosides

[0077] (1) Preparation of the water extract of Auranthus nudiflora:

[0078] Add water to 110°C for extraction once, add 12 times of water each time, extract for 1 hour for the first time, extract for 3 hours for the second time, combine the filtrates, filter, concentrate under reduced pressure at 90°C to an extract with a relative density of 1.30-1.35 , dried at 75°C to form a dry extract, and set aside;

[0079] (2) Preparation of total flavonoids from Auranthus nudica:

[0080] ①The water extract of Auranthus nudiflorum, dissolved in ethanol, is prepared as 1mg / mL ethanol solution of Aurora nudiflora;

[0081] ②The ethanol solution of Auranthus nudica is passed through AB-8 resin (the ratio of diameter to height is 1:8), 85% ethanol is used as the eluent, the injection rate is 3mL / min, the elution rate is 30 drops / min, and the eluted After the total flavonoid content ...

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PUM

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Abstract

The invention relates to a composition of a callicarpa nudiflora extract, and particularly provides a composition of a callicarpa nudiflora extract with a pharyngitis treatment function. The composition is prepared from the following components in parts by weight: 45 to 58 parts of total flavonoids of callicarpa nudiflora, 35 to 52 parts of total phenylglycosides of callicarpa nudiflora, and 28 to40 parts of total phenolic acids of callicarpa nudiflora. The invention also discloses application of the composition. The composition has the advantages that the three components are respectively extracted from the callicarpa nudiflora, the components are accurate, and the synergistic function is realized; the good pharyngitis treatment and / or preventing effect is realized.

Description

technical field [0001] The present invention relates to a nude flower composition and its application, in particular to a nude flower extract composition and its application for treating pharyngitis. Background technique [0002] Pharyngitis is a common and frequently-occurring disease, which has a greater impact on people's diet, phonation, breathing, etc. It can be divided into acute pharyngitis and chronic pharyngitis. According to the theory of traditional Chinese medicine, the pathogenesis of acute pharyngitis is mainly due to the deficiency of Yin in the lungs and kidneys, the feeling of exogenous evils, the evil poison enters through the mouth and nose, the accumulation of heat and toxins, and the wind-heat and phlegm-fire. Modern medicine then thinks that the cause of disease of acute pharyngitis comprises three kinds: 1. viral infection: coxsackie virus, adenovirus, parainfluenza virus, secondly rhinovirus, influenza virus; coccus, Haemophilus influenzae, etc., the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P11/04A61P31/14A61P31/04
CPCA61K36/85A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P11/04A61P31/04A61P31/14A61K2300/00
Inventor 李小锋陈梁刘厚权夏淑英李海金
Owner JIANGXI POZIN PHARMA
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