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A liver-protecting intestinal microecological regulator based on the liver-gut axis and its preparation method

A technology of intestinal microecology and regulator, applied in the biological field, can solve problems such as low colonization rate, single strain, and low survival rate of strains

Active Publication Date: 2021-07-06
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, among the many products in the market, almost all of them treat the two differently: Hugan Tablets, Bifendate, Compound Yiganling, etc. are often used to treat various liver diseases, so as to achieve the purpose of nourishing and protecting the liver. However, there are problems such as slow onset of action, long taking cycle, and low bioavailability, and may even cause adverse reactions such as nausea, vomiting, dermatitis, and rashes; probiotics, prebiotics, or synbiotics are often used to regulate the intestinal microecology. Quasi-intestinal regulators, especially regulators containing probiotics, often have problems such as single and unstable strains, difficulty in preservation, low survival rate of strains, and low colonization rate, and for many people with liver diseases, often appear The phenomenon of low cure rate and easy recurrence

Method used

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  • A liver-protecting intestinal microecological regulator based on the liver-gut axis and its preparation method
  • A liver-protecting intestinal microecological regulator based on the liver-gut axis and its preparation method
  • A liver-protecting intestinal microecological regulator based on the liver-gut axis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] By weight, the liver-intestine axis-based liver-protecting intestinal microecological regulator of this embodiment is prepared using the following raw materials: 150 parts of Dijincao, 130 parts of Grapevine leaves, 200 parts of raspberries, and purslane 150 parts, Polygonatum 120 parts, Cistanche 60 parts, yeast β-glucan 8 parts, fructooligosaccharides 15 parts, soybean oligosaccharides 20 parts.

[0039] The preparation method of the liver-protecting intestinal microecological regulator based on the liver-gut axis is as follows:

[0040] (1) Prepare Dijincao extract, Serpentis dentata grape leaf extract, raspberry extract respectively;

[0041] Put the pulverized 10-mesh sieve into the extraction tank, add 10 times the amount of 30% ethanol as the extraction solvent, and extract at room temperature for 10 seconds; turn on the flash extractor and vacuum The connecting valve between the decompression extractors, the feed liquid enters the vacuum decompression extractor...

Embodiment 2

[0046] By weight, the liver-intestine axis-based liver-protecting intestinal microecological regulator of this embodiment is prepared using the following raw materials: 180 parts of Dijincao, 150 parts of Grapevine leaves, 220 parts of raspberries, and purslane 180 parts, Polygonatum 140 parts, Cistanche 80 parts, yeast β-glucan 13 parts, fructooligosaccharides 20 parts, soybean oligosaccharides 40 parts.

[0047] The preparation method of the liver-protecting intestinal microecological regulator based on the liver-gut axis is as follows:

[0048] (1) Prepare Dijincao extract, Serpentis dentata grape leaf extract, raspberry extract respectively;

[0049] Put the pulverized 24-mesh sieve of Dijincao or Snakegrape leaves or raspberries into the extraction tank, add 15 times the amount of 40% ethanol as the extraction solvent, and extract at room temperature for 40 seconds; turn on the flash extractor and vacuum The connecting valve between the decompression extractors, the feed...

Embodiment 3

[0054] By weight, the liver-intestine axis-based liver-protecting intestinal microecological regulator of this embodiment is prepared from the following raw materials: 210 parts of Dijincao, 165 parts of Grapevine leaves, 240 parts of raspberries, and purslane 210 parts, Polygonatum 140 parts, Cistanche 100 parts, yeast β-glucan 16 parts, fructooligosaccharides 24 parts, soybean oligosaccharides 30 parts.

[0055] The preparation method of the liver-protecting intestinal microecological regulator based on the liver-gut axis is as follows:

[0056] (1) Prepare Dijincao extract, Serpentis dentata grape leaf extract, raspberry extract respectively;

[0057] Put the pulverized 24-mesh sieve of Dijincao or Snakegrape leaves or raspberries into the extraction tank, add 20 times the amount of 55% ethanol as the extraction solvent, and extract at room temperature for 50 seconds; turn on the flash extractor and vacuum The connecting valve between the decompression extractors, the feed...

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Abstract

The invention relates to a liver-protecting intestinal microecological regulator based on the liver-gut axis and a preparation method thereof. The raw materials for the preparation of the regulator include: 100 to 300 parts of Dijincao, 60 parts of Grapevine leaves ~210 parts, raspberry 100~300 parts, purslane 100~300 parts, sealwort 60~180 parts, cistanche 50~150 parts, yeast β-glucan 5~20 parts, fructooligosaccharides 10~50 parts, 10-60 parts of soybean oligosaccharides. Compared with drugs or prebiotics used alone, the curative effect of the present invention is significantly improved. The composition is guided by the traditional Chinese medicine health care theory and the "liver-gut axis" theory of modern medical research, and the components cooperate with each other to synergize Synergistic, safe, non-toxic and side effects, will not produce dependence, drug resistance, and will not accumulate in the body, and has precise functions of protecting the liver and regulating intestinal microecology; the preparation method of the present invention can not only retain the main active ingredients to the greatest extent , improve the yield of the extract, but also effectively reduce the extraction time and energy consumption.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a liver-protecting intestinal microecological regulator based on the liver-gut axis and a preparation method thereof. Background technique [0002] The liver is an organ whose main function is substance metabolism and detoxification, while the intestine is an organ whose main function is digestion and absorption of nutrients. It is generally believed that the two are independent of each other and do not interfere with each other. With the development of science and technology and the continuous deepening of research, more and more evidences have shown that the biological functions of the liver and the intestine are closely related and affect each other, and the theory of "liver-gut axis" was born from this. In the embryonic stage, the liver and the intestine originate from the foregut. After maturity, the two organs are mainly connected to each other through the portal vein: about 70...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P1/16A61P1/00A61K31/716A61K31/702
CPCA61K31/702A61K31/716A61K36/185A61K36/47A61K36/64A61K36/73A61K36/87A61K36/8969A61K2236/333A61K2236/51A61K2236/53A61P1/00A61P1/16A61K2300/00
Inventor 贾福怀晏永球涂宏建王俊陶刚熊菲菲王彩霞袁媛许璐云
Owner NINGBO YUFANGTANG BIOTECH
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