Composition for preventing and/or treating renal injury and renal failure

A composition and a technique for renal failure, applied in the field of medicine, can solve problems such as the treatment and prevention of renal function diseases that have not been seen in its application
CN108721601AInactive Publication Date: 2018-11-02MUDANJIANG YOUBO PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
MUDANJIANG YOUBO PHARMA CO LTD
Publication Date
2018-11-02
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a composition for preventing and / or treating renal injury and renal failure. The composition is prepared from one or more of MG53 protein and a MG53 protein mutant, wherein theMG53 protein mutant is a structure that a serine site in a Coiled-coil structural domain of the MG53 protein is mutated as alanine, specifically one or more of MG53 S150A, MG 53 S189A, MG53 S211A. The invention further discloses a composition for preventing and / or treating renal injury and renal failure. The composition containing the MG53 protein and / or the mutant thereof utilizes recombinant human MG53 protein to prove that the MG53 has obvious preventing and / or treating effect for chronic ulcer in a drug for preventing and / or treating renal injury and renal failure, and is of greater meaning in clinical application in developing a drug for treating renal injury and renal failure.
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Description

technical field

[0001] The invention relates to the field of medicine, and relates to a composition for preventing and / or treating renal damage and renal failure. Background technique

[0002] Acute kidney injury (AKI) or acute renal failure (ARF) is caused by various reasons such as infection, burn, trauma, renal artery stenosis and shock, among which sepsis is one of the most important clinical causes of acute kidney injury. It is a common clinical critical disease with acute onset, rapid course of disease, high mortality and case fatality rate, and the incidence rate is increasing year by year. Exacerbation of ARF has been reported to result in hospitalization in approximately 5%, cardiopulmonary bypass surgery in 4–15%, and intensive care in as many as 30%. Generally speaking, the fatality rate of acute kidney injury is 45%, but the fatality rate can rise to 70% after sepsis, which has become one of the major problems in critical care and emergency medicine.

[0003] C...

Claims

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