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Polylactic acid/lappaconite hydrobromide composite fiber and preparation and application thereof

A technology of homogenin hydrobromide and composite fiber, which is applied in medical science, bandages, absorbent pads, etc., can solve the problem of single performance, and achieve good biocompatibility and good drug controllable release effect

Inactive Publication Date: 2018-11-02
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For traditional surgical threads and wound dressing fibers, materials with excellent biocompatibility and molding effect are mainly selected, with single performance

Method used

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  • Polylactic acid/lappaconite hydrobromide composite fiber and preparation and application thereof
  • Polylactic acid/lappaconite hydrobromide composite fiber and preparation and application thereof
  • Polylactic acid/lappaconite hydrobromide composite fiber and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Preparation of spinning solution: use an electronic balance to accurately weigh 2.95g of polylactic acid, add it to 20ml of dichloromethane, and continue stirring for 6-12 hours until the polymer solution is evenly mixed and transparent; use an electronic balance to accurately weigh 20mg of hydrobromic acid Ujiasu was added to the mixed solution, stirred for 3 hours at a speed of 200r / min, and then ultrasonically removed for 1h at a power of 50kHz to obtain a uniform and transparent spinning solution;

[0038] Electrospinning: Fill the spinning solution into a 10ml syringe, then connect the positive pole of the high voltage power supply to the syringe needle tip of the syringe pump, and select the needle with an outer diameter of 0.6 mm and a length of 50 mm to connect the negative pole of the high voltage power supply to aluminum foil. Under the conditions of controlling the spinning temperature at 20~30°C and the humidity at 20~50%, adjust the electrospinning parameters...

Embodiment 2

[0042] Preparation of spinning solution: Accurately weigh 1.69g of polylactic acid with an electronic balance, add it to 20ml of dichloromethane, and continue stirring for 6-12 hours until the solution is evenly mixed and transparent; accurately weigh 10mg of polylactic acid, and Add it into the mixed solution and stir for 3 hours at a speed of 200r / min to obtain a uniform and transparent spinning solution;

[0043] Electrospinning: Put the spinning solution into a 10ml syringe, then connect the positive pole of the high-voltage power supply to the syringe needle tip of the syringe pump, select the needle specification as 0.6mm in outer diameter and 1.5mm in length, and connect the negative pole of the high-voltage power supply to aluminum foil; control Under the conditions of spinning temperature of 20~30℃ and humidity of 20~50%, adjust the electrospinning parameters: the distance between the nozzle and the receiving drum is 10cm, the spinning voltage is 5.1kV, and the nozzle ...

Embodiment 3

[0047] Preparation of spinning solution: Accurately weigh 2.31g of polylactic acid, add it to 20ml of dichloromethane, and keep stirring for 6-12 hours until the solution is evenly mixed and transparent; solution, stirred at a rotating speed of 200r / min for 3 hours to obtain a uniform and transparent spinning solution;

[0048] Electrospinning: Fill the spinning liquid into a 10ml syringe, then connect the positive pole of the high-voltage power supply to the syringe needle tip of the syringe pump. The needle specifications are selected to be 0.6 mm in outer diameter and 1.5 mm in length, and the negative pole of the high-voltage power supply is connected to aluminum foil. Under the conditions of controlling the spinning temperature at 20~30°C and the humidity at 20~50%, adjust the electrospinning parameters: the distance between the nozzle and the receiving drum is 11cm, the spinning voltage is 7.07kV, and the nozzle speed is 1ml / min , the nozzle speed is 1ml / min, the drum sp...

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Abstract

The invention discloses a preparation method of polylactic acid / lappaconite hydrobromide composite fiber. The preparation method comprises the following steps: firstly heating polylactic acid to be molten in dichloromethane, and then adding lappaconite hydrobromide to be stirred and mixed uniformly to obtain a uniform and transparent spinning solution; and then, transferring the spinning solutioninto an injector of an electrostatic spinning machine, and controlling electrostatic spinning conditions to perform electrostatic spinning so as to obtain the composite fiber. The polylactic acid in the composite fiber has the characteristics of good mechanical properties, biocompatibility and chemical stability and has a good drug slow release effect, and the loaded lappaconite hydrobromide has the effects of diminishing inflammation and easing pain and can be slowly released to a wound part in a degradation process so as to protect the wound and simultaneously achieve the effects of easing pain and diminishing inflammation, so that the composite fiber can serve as a drug slow release carrier material for preparing surgical sutures, wound films and the like and has the effects of diminishing wound inflammation, easing pain and regenerating tissues.

Description

technical field [0001] The present invention relates to a preparation method of a drug-loaded polylactic acid composite fiber, in particular to a preparation of a polylactic acid / homoquinone hydrobromide composite fiber, which is mainly used for preparing surgical thread, wound patch, etc., and belongs to functional material technology field. Background technique [0002] Surgical sutures refer to special threads used for ligation and hemostasis, suture hemostasis and tissue suture in surgical operations or trauma treatment. Traditional surgical threads and wound dressing fibers mainly choose materials with excellent biocompatibility and molding effect, with single performance. [0003] Polylactic acid (PLA) is a non-toxic and harmless polymer material with good biocompatibility and biodegradability. The mineralization and metabolization of its degradation products make it the most attractive medical material. polymer. Its mechanical strength and durability make polylacti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/12A61L17/00A61L15/44A61L15/26A61L15/62
CPCA61L15/26A61L15/44A61L15/62A61L17/005A61L17/12A61L2300/216A61L2300/402A61L2300/602C08L67/04
Inventor 张继陈乐乐滕桂香
Owner NORTHWEST NORMAL UNIVERSITY
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