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Magnetic cellulose/beta-cyclodextrin medicinal control-release hydrogel ball and preparation method thereof

A technology of cellulose and cyclodextrin, which is applied in drug delivery, pharmaceutical formula, capsule delivery, etc., to achieve broad application prospects, large-scale production, and convenient and controllable operation

Inactive Publication Date: 2018-11-06
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a magnetic cellulose / β-cyclodextrin drug controlled release hydrogel ball and its preparation for the shortcomings of the existing hydrogel that needs to achieve the drug sustained release effect through temperature and solution pH changes method

Method used

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  • Magnetic cellulose/beta-cyclodextrin medicinal control-release hydrogel ball and preparation method thereof
  • Magnetic cellulose/beta-cyclodextrin medicinal control-release hydrogel ball and preparation method thereof
  • Magnetic cellulose/beta-cyclodextrin medicinal control-release hydrogel ball and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A method for preparing magnetic cellulose / beta-cyclodextrin drug controlled release hydrogel balls, the specific steps are:

[0032] (1) Add 2.0 cotton linter fiber raw materials into 98g lithium hydroxide-urea-water cellulose dissolving system, stir rapidly to form a homogeneous cellulose solution;

[0033] (2) Take 2.0g of β-cyclodextrin and add it to the homogeneous cellulose solution, then add 2ml of epichlorohydrin cross-linking agent, and stir rapidly for 40 minutes to make it fully react so that β-cyclodextrin is grafted onto the On the cellulose macromolecular skeleton; then add 0.5g of Fe 3 o 4 For magnetic nanoparticles, after fully stirring and dispersing for 30 min, slowly drop the mixed solution into ethanol aqueous solution (50wt%) to obtain spherical magnetic cellulose / β-cyclodextrin hydrogel, which is washed and purified to obtain the finished product.

Embodiment 2

[0035] A method for preparing magnetic cellulose / beta-cyclodextrin drug controlled release hydrogel balls, the specific steps are:

[0036] (1) Add 3.0 microcrystalline cellulose fiber raw materials into 97g sodium hydroxide-urea-water cellulose dissolution system, and stir rapidly to form a homogeneous cellulose solution;

[0037] (2) Take 3.0g of β-cyclodextrin and add it to the homogeneous cellulose solution, then add 3ml of epichlorohydrin crosslinking agent, and stir rapidly for 40 minutes to make it fully react and graft β-cyclodextrin to the On the skeleton of cellulose macromolecules. Then add 1.5g of Fe 3 o 4 For magnetic nanoparticles, after fully stirring and dispersing for 30 min, slowly drop the mixed solution into methanol aqueous solution (50wt%) to obtain spherical magnetic cellulose / β-cyclodextrin hydrogel, which is washed and purified to obtain the finished product.

Embodiment 3

[0039] A method for preparing magnetic cellulose / beta-cyclodextrin drug controlled release hydrogel balls, the specific steps are:

[0040] (1) Add 4.0 pulp fiber raw materials into 96g sodium hydroxide-urea-water cellulose dissolving system, stir rapidly to form a homogeneous cellulose solution;

[0041] (2) Take 4.0g of β-cyclodextrin and add it to the homogeneous cellulose solution, then add 4ml of epichlorohydrin cross-linking agent, and stir rapidly for 40 minutes to make it fully react so that β-cyclodextrin is grafted onto the On the skeleton of cellulose macromolecules. Then add 0.5g of Fe 3 o 4 For magnetic nanoparticles, after fully stirring and dispersing for 30 minutes, slowly drop the mixed solution into 10% potassium chloride aqueous solution to obtain spherical magnetic cellulose / β-cyclodextrin hydrogel, which is washed and purified to obtain the finished product.

[0042] Practical application:

[0043] (1) Place the composite hydrogel sphere in 1 mg / ml 5-f...

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Abstract

The invention belongs to the field of biomass functional polymer materials, and specifically relates to a magnetic cellulose / beta-cyclodextrin medicinal control-release hydrogel ball and a preparationmethod thereof. The preparation method comprises following steps: (1) adding cellulose into a cellulose dissolving system, and rapidly stirring to form a cellulose uniform solution; and (2) adding acertain amount of beta-cyclodextrin into the cellulose uniform solution, then adding a certain amount of epoxy chloropropane crosslinking agent, rapidly stirring for 40 minutes, then adding a certainamount of Fe3O4 magnetic nano particles, fully stirring and dispersing the solution for 30 minutes, slowly and dropwise adding the mixed solution into a cured solution to obtain spherical magnetic cellulose / beta-cyclodextrin hydrogel, and washing and purifying the hydrogel to obtain composite hydrogel balls. Through an external magnetic field, remote controlled drug release can be realized in-vitro, direct contact with a drug carrier is not needed, the operation is convenient and controllable, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the field of biomass functional polymer materials, and in particular relates to a magnetic cellulose / beta-cyclodextrin medicine controllable release hydrogel ball and a preparation method thereof. Background technique [0002] Magnetic hydrogels are a kind of inorganic / organic functional composite materials with the characteristics of magnetic materials, polymer materials and hydrogels. Due to its excellent magnetic properties and biocompatibility, as a new generation of drug carrier, it can realize functions such as magnetic response, magnetic targeting and magnetic hyperthermia, and has broad application prospects in the field of controlled drug release. Among them, the polymers of synthetic hydrogels include natural polymers and synthetic polymers. Natural polymers have attracted widespread attention because of their advantages such as wide sources, low price, good biocompatibility and biodegradability. [0003] Cellulose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/513A61K47/02A61K47/40A61K47/38
CPCA61K9/0009A61K9/5036A61K9/5042A61K31/513A61K47/02
Inventor 卢贝丽林凤采卢麒麟黄彪林强武羽岩
Owner FUJIAN AGRI & FORESTRY UNIV
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