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A heavy metal ion-free porphyrin compound contrast agent and its application in magnetic resonance imaging

A technology of porphyrin compounds and heavy metal ions, which is used in nuclear magnetic resonance/magnetic resonance imaging contrast agents, applications, medical science, etc., can solve problems such as small chemical shift values, and achieve the effect of avoiding burden and solving low imaging sensitivity.

Active Publication Date: 2021-03-02
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, in this research field, most of the exchangeable protons are located in the low-field region relative to water (low-field means that the chemical shift value relative to water is relatively large, generally positive), while the high-field region (high field refers to the Relative to the chemical shift value of water is relatively small, generally negative) signal has not been reported

Method used

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  • A heavy metal ion-free porphyrin compound contrast agent and its application in magnetic resonance imaging
  • A heavy metal ion-free porphyrin compound contrast agent and its application in magnetic resonance imaging
  • A heavy metal ion-free porphyrin compound contrast agent and its application in magnetic resonance imaging

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Embodiment 1

[0033]The application of a heavy metal ion-free porphyrin compound as a contrast agent in magnetic resonance imaging includes the following steps:

[0034]Step 1. Select tetracarboxyphenyl porphyrin;

[0035]Step 2. Weigh 95 mg of tetracarboxyphenyl porphyrin and dissolve it in 1 mL of deionized water, then adjust the pH to 7 with hydrochloric acid (HCl solution) or sodium hydroxide solution (NaOH solution), and the concentration is 0.125mol / L MRI contrast agent;

[0036]Step 3. Take mice weighing 20-25g, and use the volume ratio of 2-3% Isoflurane / Oxygen (Oxygen, Oxygen, O2) Gas anesthetize the mouse placed on the animal bed, make it prone, the kidney part is at the center of the coil, fix it with tape and send it into the MRI machine, and use the respiratory monitor to monitor the respiratory rate, and control the respiratory rate by the amount of isoflurane Around 20 times / min;

[0037]Step 4. Quickly perform tuning, shimming, frequency matching, gain adjustment, acquisition of positioning i...

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Abstract

The invention discloses the application of a porphyrin compound without heavy metal ions as a contrast agent in magnetic resonance imaging. Contrast agents are easy to increase the burden of liver and kidney metabolism in patients. The present invention detects the signal of porphyrin compounds by using chemical exchange saturation transfer magnetic resonance imaging technology by injecting porphyrin compounds without heavy metal ions, and finally reduces the background signal and improves the imaging performance of magnetic resonance imaging. Sensitivity, has practical significance and clinical value.

Description

Technical field[0001]The invention belongs to the technical field of magnetic resonance contrast agents and biological environment detection, and specifically relates to a heavy metal ion-free porphyrin compound contrast agent and its application in magnetic resonance imaging.Background technique[0002]Magnetic resonance imaging (MRI) has the characteristics of high spatial resolution and safety without radiation damage, and has been widely used in clinical medical diagnosis. Regarding the problems of low MRI sensitivity leading to the inconspicuous contrast of certain different tissues or tumor tissues and difficult diagnosis, the current clinical contrast agents mainly improve the accuracy of the diagnosis by changing the local relaxation characteristics of the tissues and improving the imaging contrast. Sex. Such contrast agents often require the use of high doses of heavy metal ions, such as gadolinium ions (Gd ions).3+), iron ions (Ironions, Fe3+), Manganese ions (Mn3+), etc. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61B5/055
CPCA61B5/055A61K49/06
Inventor 周欣张肖肖袁亚平郭茜旎孙献平刘买利
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI