BMP-2 loaded strontium substituted hydroxyapatite/silk fibroin/heparin composite scaffold and preparation method and application thereof
A technology of strontium hydroxyapatite and BMP-2, which is applied in the fields of medical science, prosthesis, tissue regeneration, etc., to achieve the effect of easy availability of raw materials and simple preparation process
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Embodiment 1
[0043] Example 1 Nano strontium-doped strontium-doped hydroxyapatite / silk fibroin / heparin composite scaffold loaded with BMP-2 and its preparation method
[0044] The preparation method of the BMP-2-loaded nano strontium-doped hydroxyapatite / silk fibroin / heparin composite scaffold includes the following steps:
[0045] (1) Take 8 g of silkworm cocoons without chrysalis and place them in 400 mL of deionized water containing 2 g of sodium bicarbonate, heat them to boiling, and after boiling for half an hour, take them out and wash them with deionized water, repeat the above operations until they are deionized with picric acid The carmine method qualitatively judges that silk fibroin no longer contains sericin. Then place the obtained silk fibroin in an oven at a temperature of 50° C., heat and dry overnight to remove moisture in the silk fibroin, and obtain the silk fibroin for use.
[0046] (2) Take 2.5g of pure silk fibroin and cut it into small pieces, put it in 25mL lithium...
Embodiment 2
[0054] Example 2 Hydroxyapatite / silk fibroin composite scaffold loaded with BMP-2 and its preparation method
[0055] The preparation method of the hydroxyapatite / silk fibroin composite scaffold loaded with BMP-2 of the present embodiment comprises the following steps:
[0056] (1) Take 8 g of silkworm cocoons without chrysalis and place them in 400 mL of deionized water containing 2 g of sodium bicarbonate, heat them to boiling, and after boiling for half an hour, take them out and wash them with deionized water, repeat the above operations until they are deionized with picric acid The carmine method qualitatively judges that silk fibroin no longer contains sericin. Then place the obtained silk fibroin in an oven at a temperature of 50° C., heat and dry overnight to remove moisture in the silk fibroin, and obtain the silk fibroin for use.
[0057] (2) Take 1 g of pure silk fibroin and cut it into small pieces, place it in 12.5 mL of lithium bromide solution with a concentrat...
Embodiment 3
[0060] Example 3 Nano strontium-doped hydroxyapatite / silk fibroin / heparin composite scaffold loaded with BMP-2 and its preparation method
[0061] The BMP-2-loaded nano strontium-doped hydroxyapatite / silk fibroin / heparin composite scaffold and the preparation method thereof in this embodiment include the following steps:
[0062] (1) Take 8 g of silkworm cocoons without chrysalis and place them in 400 mL of deionized water containing 2 g of sodium bicarbonate, heat them to boiling, and after boiling for half an hour, take them out and wash them with deionized water, repeat the above operations until they are deionized with picric acid The carmine method qualitatively judges that silk fibroin no longer contains sericin. Then place the obtained silk fibroin in an oven at a temperature of 50° C., heat and dry overnight to remove moisture in the silk fibroin, and obtain the silk fibroin for use.
[0063] (2) Take 2.5g of pure silk fibroin and cut it into small pieces, put it in 5...
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