Biomarker for systemic sclerosis diagnosis and PAH prediction

A technology for biological samples and reactive proteins, which can be used in disease diagnosis, biological testing, biological material analysis, etc., and can solve problems such as incomplete disease diagnosis.

Active Publication Date: 2018-11-09
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that currently relying on histopathological biopsy, biochemical examination and serum autoantibody examin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biomarker for systemic sclerosis diagnosis and PAH prediction
  • Biomarker for systemic sclerosis diagnosis and PAH prediction
  • Biomarker for systemic sclerosis diagnosis and PAH prediction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]40 SSc patients, 30 autoimmune disease control patients and 20 normal controls were screened for SSc-related autoantibody target antigens using high-throughput protein chip technology containing 21,065 non-redundant recombinant human proteins. The analysis confirmed that 113 SSc-related autoantibody target antigens were screened out. In order to confirm the sensitivity, specificity and clinical application value of these SSc-related autoantibodies, 113 SSc-related autoantibodies corresponding to target antigens were used to construct and prepare SSc-related autoantibody target antigen protein chips for 400 cases of SSc patients and 160 cases of autoimmune diseases. Control patients (including 36 patients with rheumatoid arthritis, 37 patients with systemic lupus erythematosus, 37 patients with Sjogren's syndrome, 25 patients with dermatomyositis and 25 patients with polymyositis), 40 control patients with other chronic diseases (7 cases of endocrine system diseases, 8 ca...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a disintegrin and metalloproteinase 4 which is ADAMTSL4 with a 1-type thrombospondin motif, or application of a fragment thereof in preparing a reagent for predicting pulmonaryarterial hypertension possibility in systemic sclerosis. 113 SSc associated autoantibodies target antigens are screened by adopting a high-density protein chip technology. 113 SSc associated autoantibodies corresponding target antigens are adopted to build and prepare protein chips of the SSc associated autoantibodies target antigens for carrying out clinic enlarged sample verification. The result shows that the positive rate of the anti-ADAMTSL4 antibody in a PAH patient with SSc is 14.9 percent which is remarkably higher than the positive rate (2.88 percent) of the anti-ADAMTSL4 antibody ina PAH patient without SSc, so that the possibility of the PAH occurrence in SSc can be predicted.

Description

technical field [0001] The invention belongs to the field of biological detection, and specifically relates to biomarkers for systemic sclerosis diagnosis and PAH prediction and uses thereof. Background technique [0002] Systemic sclerosis (SSc), also known as scleroderma, is a systemic autoimmune disease characterized by localized or diffuse skin thickening and fibrosis. The main features of the disease are innate and adaptive immune dysfunction and microvascular damage, which eventually lead to excessive production and accumulation of extracellular matrix and collagen. Although clinically, progressive skin thickening and hardening and fibrosis are usually the main features, but in addition to skin involvement, fibrotic lesions can also involve multiple internal organs (lungs, heart, kidneys, and digestive tract, etc.), and These changes are the decisive factors of clinical prognosis. Among them, interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N33/53
CPCG01N33/53G01N2800/285
Inventor 李永哲胡朝军吴琳刘晨曦李柳冰张奉春
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap