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Chenodeoxycholic acid and preparation method of intermediate of chenodeoxycholic acid

A technology of chenodeoxycholic acid and hyodeoxycholic acid, which is applied in the field of organic chemical synthesis and can solve the problems of large environmental pollution and many synthesis steps

Inactive Publication Date: 2018-11-13
SHANDONG RUIYING PIONEER PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the process of synthesizing chenodeoxycholic acid from hyodeoxycholic acid has problems such as many synthesis steps and large environmental pollution.

Method used

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Embodiment 1

[0027] A kind of preparation method of chenodeoxycholic acid and intermediate thereof of the present embodiment, comprises the following steps:

[0028] 1. Preparation of methyl hyodeoxycholic acid refined product Ⅰ

[0029] Take 7.5g of commercially available hyodeoxycholic acid (the content of hyodeoxycholic acid is 80%, and the content of hyodeoxycholic acid is 20%), add 50mL of methanol, cool down to 5°C, add 0.25mL of concentrated sulfuric acid dropwise, and drop it within 10 minutes , raised to 25°C, stirred at controlled temperature for about 15 hours, tracked by TLC, the developer was dichloromethane: acetone: acetic acid = 2:1:0.1. After the reaction is complete, add 10 mL of saturated NaHCO 3 solution, quenching the reaction. Concentrate under reduced pressure to remove methanol, extract twice with 50 mL ethyl ester, and combine the organic phases. Add 35mL saturated NaHCO 3 Wash the organic phase, separate the layers, add 50 mL of saturated brine to wash once, a...

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Abstract

The invention discloses chenodeoxycholic acid and a preparation method of an intermediate of the chenodeoxycholic acid. In the invention, commercial hyodeoxycholic acid is used as a raw material, andthe preparation method comprises the following steps: performing side chain carboxylmethylation,recrystallization,6 alpha-hydroxyl selective oxidation, and introducing into beta-bromine at the position 7 to obtain an intermediate III with the total yield of 16%; and reducing and hydrolyzing the intermediate III to obtain the chenodeoxycholic acid. The method is short in reaction route, is free ofreagents, such astrimethylchlorosilane and highly-toxic p-toluenesulfonylhydrazide, and is relatively low in environmental pollution; and the synthesized intermediate III plays an important role in the synthesis of cholic acid drugs.

Description

technical field [0001] The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method of chenodeoxycholic acid and an intermediate. Background technique [0002] The main function of chenodeoxycholic acid (CDCA) is to reduce the saturation of cholesterol in the bile. After the vast majority of patients take CDCA, when CDCA accounts for 70% of the bile salt in the bile, the lipids return to the state of micelles, and the cholesterol is in the state of micelles. unsaturated state, so that the cholesterol in the stones dissolves and falls off. Large doses of CDCA can inhibit the synthesis of cholesterol and increase the secretion of bile in patients with cholelithiasis, but the secretion of bile salts and phospholipids remains unchanged. In addition, chenodeoxycholic acid is a raw material for the synthesis of ursodeoxycholic acid and other steroidal compounds. As an epimer of ursodeoxycholic acid, its artificial synthesis has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
CPCC07J9/005
Inventor 韩迎彭继先孙文庆张国占
Owner SHANDONG RUIYING PIONEER PHARMA
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