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Curcumin solid dispersion and preparation method and application thereof

A solid dispersion, curcumin technology, applied in the application, non-active ingredient medical preparations, pharmaceutical formulas and other directions, can solve the problems of poor water solubility, low absolute bioavailability, and low blood drug concentration of curcumin preparations, and achieves Improve oral bioavailability, reduce drug dosage, lower blood sugar and resist stress

Inactive Publication Date: 2018-11-16
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is to overcome the problems of poor water solubility of existing curcumin preparations, poor oral absorption, low blood drug concentration, short half-life, low bioavailability, and low absolute bioavailability. Utilization, reduced usage dose, lower usage cost, research and development of curcumin solid dispersion

Method used

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  • Curcumin solid dispersion and preparation method and application thereof
  • Curcumin solid dispersion and preparation method and application thereof
  • Curcumin solid dispersion and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Prepare curcumin solid dispersion according to the following steps:

[0050] S1. Weigh 10.0% curcumin bulk drug, 25.0% hydroxypropyl-β-cyclodextrin, 10.0% polyethylene glycol 6000, 30.0% polyethylene monostearate, 10% Tween-80, peppermint Oil 10.0%; polyethylene glycol 6000, hydroxypropyl-β-cyclodextrin was heated and melted at 90°C to obtain a mixture.

[0051] S2. After dissolving the curcumin raw material in medicinal ethanol, add polyethylene monostearate in the proportion described in S1, fully oscillate and mix evenly to prepare the mixture;

[0052] S3 adding the mixture obtained in S2 to the mixture described in step S1, stirring evenly to combine the curcumin molecules with the carrier to obtain the mixture;

[0053] S4. Add peppermint oil to the mixture C obtained in step S3, and stir evenly at a heat preservation temperature of 40° C. to obtain a mixture;

[0054] S5. Cool the mixture in step S4 to 20°C-30°C, spray and granulate the mixture in a fluidized b...

Embodiment 2

[0057] S1. Weigh 10% of curcumin crude drug according to the proportion, 20.0% of phospholipid, 20.0% of polyethylene glycol 6000, 40.0% of polyoxyethylene castor oil, 10% of clove oil; get a mixture;

[0058] S2. After dissolving the curcumin raw material with ethanol, add the polyoxyethylene castor oil of the ratio described in S1, fully shake and mix to prepare the mixture;

[0059] S3 adding the mixture obtained in S2 to the mixture described in step S1, stirring evenly to combine the curcumin molecules with the carrier to obtain the mixture;

[0060] S4. Add clove oil to the mixture C obtained in step S3, and stir evenly at a heat preservation temperature of 40° C. to obtain a mixture;

[0061] S5. Cool the mixture in step S4 to 20°C to 30°C, spray and granulate the mixture in a fluidized bed; the temperature of the fluidizing air is 20°C, and the linear velocity is 80 m / s;

[0062] S6. Cool the granules described in step S5, and collect granules with a particle size be...

Embodiment 3

[0064] S1. Weigh 10.0% curcumin crude drug according to the proportion, polyethylene glycol 6000 30.0%, hydroxypropyl-β-cyclodextrin 25.0%, Tween-80 25.0%, sorbitol 10.0%; polyethylene glycol 6000 , Hydroxypropyl-β-cyclodextrin was heated and melted at 90°C to obtain a mixture;

[0065] S2. After dissolving the curcumin raw material in ethanol, add Tween-80 in the proportion described in S1, fully oscillate and mix evenly to prepare the mixture;

[0066] S3 adding the mixture obtained in S2 to the mixture described in step S1, stirring evenly to combine the curcumin molecules with the carrier to obtain the mixture;

[0067] S4. Adding sorbitol to the mixture C obtained in step S3, and stirring evenly at a heat preservation temperature of 40° C. to obtain the mixture;

[0068] S5. Cool the mixture in step S4 to 20°C-30°C, spray and granulate the mixture in a fluidized bed; the temperature of the fluidizing air is 20°C, and the linear velocity is 135 m / s;

[0069] S6. Cool the...

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Abstract

The invention discloses a curcumin solid dispersion and a preparation method and application thereof. The curcumin solid dispersion comprises the following components (by weight): the ratio of curcumin raw material: water-soluble carrier: solubilizer: flavoring agent is 2:2-8:6-15:1-2. The components of the curcumin solid dispersion are thoroughly mixed according to a specific suitable sequence and process; and combined with a fluidized bed spray granulation method, particles are more uniform, and the drug and carrier ingredients are more fully combined. The curcumin of the obtained product has outstanding solubility. The pharmacokinetic test in pigs shows that peak concentration is significantly improved, the bioavailability is significantly higher than bioavailability of a common preparation, and the curative effect of curcumin in clinical application is raised. The dosage is reduced, and palatability is good. The preparation process is simple but not cumbersome; energy consumption is low; drug cost is reduced; dust and static electricity are avoided; and the preparation process is easy for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of animal medicines. More specifically, it relates to a curcumin solid dispersion and its preparation method and application. Background technique [0002] Curcumin (curcumin) is a herbal polyphenol compound, which is mainly extracted from some plant rhizomes in Zingiberaceae and Araceae. It was first isolated from Curcuma longa (Curcumin longa) in 1870. The World Health Organization (World Health Organization), the US Food and Drug Administration (Food and Drug Administration) and many countries have approved the use of curcumin as a food additive, and it is widely used in countries all over the world. In recent years, with the continuous improvement of people's living standards, people's awareness of the threat brought by antibiotics has been deepened, and the safety requirements for animal products have also been increased. Curcumin is a rich natural green product and a new type of feed additive. It can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/10A61K47/44A61K47/40A61K47/26A61K31/12A61P3/06A61P3/10A61P29/00A61P39/06A61P35/00A61P31/00A23K20/105
CPCA23K20/105A61K9/1617A61K9/1623A61K9/1641A61K9/1652A61K31/12A61P3/06A61P3/10A61P29/00A61P31/00A61P35/00A61P39/06
Inventor 黄显会黄春梅张申李洁华成云
Owner SOUTH CHINA AGRI UNIV
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