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Preparation method for hafnium oxide (HfO2) nanoparticles with radiosensitization effect

A nanoparticle and hafnium oxide technology, which is applied in the direction of heavy metal active ingredients, X-ray contrast agent preparation, microcapsules, etc., to achieve the effect of short preparation time and ensuring hydrophilic performance

Active Publication Date: 2018-11-16
ZHEJIANG UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to propose a HfO with radiosensitization function in view of the complexity, dispersibility and stability of the current nanoparticle synthesis. 2 A Simple Preparation Method of Nanoparticles

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  • Preparation method for hafnium oxide (HfO2) nanoparticles with radiosensitization effect
  • Preparation method for hafnium oxide (HfO2) nanoparticles with radiosensitization effect
  • Preparation method for hafnium oxide (HfO2) nanoparticles with radiosensitization effect

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Embodiment Construction

[0017] The invention will be further explained below in conjunction with the embodiments and drawings; in this embodiment, in vitro and HfO 2 The anti-tumor effect of the nanoparticles injected into the tail vein of mice illustrates the function of radiosensitization.

[0018] A kind of HfO with radiotherapy sensitization function 2 A method for preparing nanoparticles, the method includes the following steps:

[0019] (1) 1.601g hafnium tetrachloride (HfCl 4 ) Dissolve it in 100 mL of ultrapure water, stir it magnetically in a 60°C constant temperature water bath for 2 hours to obtain solution A;

[0020] (2) Divide 10 mL of the A solution obtained in (1) into three beakers, and slowly add 10 mL of 0.05 mol / L sodium hydroxide (NaOH) solution to three HfCl 4 In the beaker of the solution, continue stirring at room temperature for 1 hour to obtain a transparent microwave hydrothermal precursor;

[0021] (3) Put the precursor solution obtained in (2) into three microwave hydrothermal ket...

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Abstract

The invention discloses a preparation method for HfO2 nanoparticles with radiosensitization effect. The method utilizes a microwave hydrothermal technology and comprises the following basic steps: preparation of a hafnium-containing precursor solution; microwave hydrothermal treatment; centrifugal washing; and freeze drying. The HfO2 nanoparticles prepared through microwave hydrothermal treatmenthave good dispersibility and have sizes of 65 nm. Research results show that the HfO2 nanoparticles have good biocompatibility and radiosensitization effect. The preparation method for the HfO2 nanoparticles is simple in process, short in desired preparation time and low in the cost for raw materials; and the HfO2 nanoparticles are totally prepared in an air atmosphere, and no special apparatus isneeded.

Description

Technical field [0001] The invention relates to a HfO with radiotherapy sensitization 2 Nano material preparation method, used for tumor treatment. Background technique [0002] Malignant tumors are one of the main causes of human death and pose a huge threat to human health. Radiotherapy, surgical treatment and chemotherapy are the three methods commonly used in clinical treatment of tumors. Among them, radiotherapy mainly uses high-energy X-rays or γ-rays to generate free radicals or DNA damage from photoelectrons to induce apoptosis to kill cancer cells and destroy cancer tissues, making them shrink or even disappear to achieve the therapeutic effect. However, due to the heterogeneity of tumors and radiation resistance (such as hypoxia) caused by various reasons, the dose of radiotherapy has to be increased clinically to improve the efficacy, which limits its effect in tumor treatment. In addition, the positioning and diagnosis of the tumor tissue is not accurate enough to e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K49/04A61K33/24A61P35/00
CPCA61K9/51A61K33/24A61K49/04A61P35/00
Inventor 周民李杨杨祁宇宸马飞
Owner ZHEJIANG UNIV
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