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Anticancer red ginseng and preparation method and application thereof

A technology of red ginseng and ginseng, applied in the field of anti-cancer red ginseng and its preparation, to achieve the effect of exact content, remarkable anti-cancer effect and clear components

Active Publication Date: 2018-11-20
SUNFLOWER PHARM GRP (TIANJIN) DRUG RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the preparation of red ginseng containing aglycone by utilizing the synergistic enzyme system of ginseng itself

Method used

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  • Anticancer red ginseng and preparation method and application thereof
  • Anticancer red ginseng and preparation method and application thereof
  • Anticancer red ginseng and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1: Preparation method of high-activity anti-cancer red ginseng

[0071] Pick 1 kg of fresh ginseng without disease, soak it in water for 30 minutes, wash it, and place it in a thermostat to keep the temperature at 110°C for 20 minutes to activate the ginseng traditional Chinese medicine glucosidase, then cool it down to 50°C and keep it warm for 10 minutes. The traditional Chinese medicine sidase I fully reacted with the original ginsenoside; then the temperature was quickly raised to 65°C and kept for 15 minutes to make the traditional Chinese medicine sidase II fully react with the ginsenoside; then the temperature was raised to 80°C and kept for 18 minutes to make the traditional Chinese medicine sidase III Fully react with ginsenosides; then quickly raise the temperature to 145°C and treat for 45 minutes to inactivate the Chinese medicine glycosides. Finally, it is dried at 60°C until the moisture content is below 10%, which is the finished high-activity anti-c...

Embodiment 2

[0083] Example 2: Preparation method of anticancer American red ginseng

[0084] Pick 1kg of fresh American ginseng without disease, soak it in water for 10 minutes, wash it, and place it in a thermostat to keep the temperature at 105°C for 28 minutes to activate the ginseng traditional Chinese medicine glucosidase, then cool naturally to 55°C and keep it warm for 9 minutes. The traditional Chinese medicine sidase I fully reacted with the original ginsenoside; then the temperature was quickly raised to 60°C and kept for 17 minutes to make the traditional Chinese medicine sidase II fully react with the ginsenoside; then the temperature was raised to 73°C and kept for 17 minutes to make the traditional Chinese medicine sidase III Fully react with ginsenosides; then quickly raise the temperature to 150°C and treat for 30 minutes to inactivate the traditional Chinese medicine glycosides. Finally, it is dried at 60°C until the moisture content is below 10%, which is the finished high-...

Embodiment 3

[0091] Example 3: Preparation method of anticancer Panax notoginseng red ginseng

[0092] Select 1kg of fresh Panax notoginseng without disease, soak in water for 18min, wash it, and place it in a thermostat to keep the temperature at 115℃ for 15min to activate the ginseng sidase; then naturally cool down to 50℃ and keep it warm for 14 minutes , Make the traditional Chinese medicine glucosidase I fully react with the original ginsenoside; then quickly raise the temperature to 65°C and keep it for 15 minutes to make the traditional Chinese medicine glucosidase II fully react with the ginsenoside; then heat up to 85°C and keep it warm for 16 minutes to make the traditional Chinese medicine glucoside Enzyme III fully reacts with ginsenosides; then, the temperature is rapidly raised to 121°C and treated for 60 minutes to inactivate the traditional Chinese medicine glycosides. Finally, it is dried at 60°C until the moisture content is below 10%.

[0093] Analyze the content of the comp...

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Abstract

The invention provides anticancer red ginseng and a preparation method and the application thereof. In the anticancer red ginseng, the molar number of rare ginsenosides and sapogenin accounts for morethan 70% of the molar number of total saponin, wherein the molar number of the sapogenin accounts for more than 20% of the molar number of the total saponin; and under the condition of not introducing any foreign substances, three natural traditional Chinese medicine glycosides enzymes in ginseng are activated, and under the action of three synergistic enzymes, different catalytic reactions are controlled to be activated under different conditions, so that original ginseng saponins which are low in activity and hard to absorb, such as Rb, Rc, Rd, Re, Rf, and Rg1, are converted into the rare saponin and sapogenin which are high inactivity. The anticancer red ginseng has the remarkable anticancer effect and the broad prospect in the preparation of anticancer drugs.

Description

Technical field [0001] The invention belongs to the field of red ginseng processing, and particularly relates to an anti-cancer red ginseng and a preparation method and application thereof. Background technique [0002] Ginseng plants play an irreplaceable role in the field of Chinese medicine with their outstanding medicinal value. Ginseng is both a species name and a genus name. The genus Ginseng belongs to the Araliaceae family, including more than ten species. The commonly used medicinal materials of the genus Ginseng are ginseng (Chinese ginseng, Korean ginseng), American ginseng (American ginseng), and Panax notoginseng (Tianqi). Seven ginseng) bamboo joint ginseng and so on. Saponins, that is, ginsenosides are its signature active ingredients. Saponins are formed by connecting non-glycosyl ligands and sugar groups through glycosidic bonds. The highest content is tetracyclic triterpene dammarane type protodiol saponins , Proto-panaxatriol saponins. The structures of thes...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K31/704A61P35/00A61K8/63A61Q19/00
CPCA61K8/63A61K31/575A61K31/704A61P35/00A61Q19/00A61K2300/00
Inventor 肖永坤王东明栾桂花
Owner SUNFLOWER PHARM GRP (TIANJIN) DRUG RES INST CO LTD
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