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Synthetic catalyst for L-alpha glycerylphosphorylcholine and preparation method thereof

A technology of glycerol phosphatidylcholine and catalyst, which is applied in the field of synthesis catalyst of glycerol phosphatidylcholine and its preparation, which can solve the problems of low yield and achieve the effects of promoting preparation, easy availability of raw materials, and simple process

Inactive Publication Date: 2018-11-23
WUHU FOMAN BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although the above method can prepare glycerol phosphatidylcholine, it generally has a low yield

Method used

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  • Synthetic catalyst for L-alpha glycerylphosphorylcholine and preparation method thereof
  • Synthetic catalyst for L-alpha glycerylphosphorylcholine and preparation method thereof

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preparation example Construction

[0021] The present invention provides a kind of preparation method of the synthesis catalyst of glycerol phosphatidylcholine, comprising:

[0022] 1) mixing vanadium chloride, copper salt, tin salt, expanded vermiculite and alcohol to form a mixed solution;

[0023] 2) mixing the mixed solution and water, and then performing a solvothermal reaction to obtain a reaction product;

[0024] 3) Calcining the reaction product to obtain the synthesis catalyst of glycerol phosphatidylcholine.

[0025] In step 1) of the above-mentioned preparation method, the consumption of materials can be selected in a wide range, but in order to further improve the catalytic efficiency of the catalyst, preferably, in step 1), the vanadium chloride, copper salt, tin salt , The dosage ratio of expanded vermiculite to alcohol is 10mmol: 1-1.5mmol: 2.5-4mmol: 0.1-0.4mmol: 20-40mL.

[0026] In step 2) of the above-mentioned preparation method, the consumption of materials can be selected in a wide rang...

Embodiment 1

[0034] 1) Vanadium chloride, copper salt (copper chloride), tin salt (tin methanesulfonate), expanded vermiculite and alcohol (ethanol) according to 10mmol: 1-1.5mmol: 2.5-4mmol: 0.1-0.4g: 20 -40mL is mixed in proportion (mixing temperature is 25°C, mixing time is 50min) to form a mixed solution;

[0035] 2) Mix the mixed solution and water according to the volume ratio of 1:1.8 (the mixing temperature is 25°C, the mixing time is 50min), and then carry out solvothermal reaction (the reaction temperature is 130°C, the reaction time is 7h) to obtain the reaction product;

[0036] 3) The reaction product is calcined (from 25°C to 200°C at a rate of 1.8°C / min and kept for 3 hours, then heated to 470°C at a rate of 1°C / min and kept for 3.5 hours, then cooled to 25°C) to obtain the synthesis catalyst A1 of the glycerol phosphatidylcholine.

Embodiment 2

[0038] 1) Vanadium chloride, copper salt (copper sulfate), tin salt (tin ethanesulfonate), expanded vermiculite and alcohol (propanol) according to 10mmol: 1-1.5mmol: 2.5-4mmol: 0.1-0.4g: 20-40mL is mixed in proportion (mixing temperature is 15°C, mixing time is 60min) to form a mixed solution;

[0039] 2) Mix the mixed solution and water according to the volume ratio of 1:1.5 (the mixing temperature is 15°C, the mixing time is 60min), and then perform solvothermal reaction (the reaction temperature is 120°C, the reaction time is 8h) to obtain the reaction product;

[0040] 3) Calcining the reaction product (increasing the temperature from 15°C to 180°C at a rate of 1.5°C / min and maintaining it for 2 hours, then raising the temperature to 450°C at a rate of 0.8°C / min and maintaining it for 3 hours, then cooling to 15°C ℃) to prepare the synthesis catalyst A2 of the glycerol phosphatidylcholine.

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Abstract

The invention discloses a synthetic catalyst for L-alpha glycerylphosphorylcholine and a preparation method thereof. The preparation method comprises the following steps: 1) mixing vanadinu chloride,copper salt, tin salt, expanded vermiculite and alcohol to form a mixed solution; 2) mixing the mixed solution and water, and then performing a solvothermal reaction to obtain a reaction product; 3) calcining the reaction product in order to obtain the synthetic catalyst for the L-alpha glycerylphosphorylcholine. The catalyst can be used for efficiently promoting the preparation of the L-alpha glycerylphosphorylcholine; meanwhile, the preparation method has the advantages of simple procedures and easy availability of raw materials.

Description

technical field [0001] The invention relates to the preparation of glycerol phosphatidylcholine, in particular to a synthesis catalyst of glycerol phosphatidylcholine and a preparation method thereof. Background technique [0002] Glycerol phosphatidylcholine is the product of two fatty acyl groups on the phosphatidylcholine (PC) molecule being completely hydrolyzed. It has a significant effect on stabilizing the cognitive ability of the brain, and can even repair some of the early senile dementia patients. Impaired cognitive abilities. Unlike drugs that inhibit the breakdown of acetylcholine, GPC stimulates the body to produce new phosphatidylcholine. Animal studies have shown that GPC can prevent memory loss. Compared with a control group of experimental conditions, it was found that older mice fed GPC mice had less loss of neural connections in the hippocampus, an area of ​​the brain dedicated to memory and learning. Based on a review of 13 clinical trial reports, scie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J23/847C07F9/09
CPCB01J23/8472B01J2523/00C07F9/091B01J2523/17B01J2523/43B01J2523/55
Inventor 苏福男
Owner WUHU FOMAN BIOPHARMA CO LTD
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