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Adhesive patch product

A patch and product technology, applied in the field of patch products, can solve problems such as increased concentration of nafurafine, sleep disorders, disorders, etc., and achieve excellent stability over time and the effect of inhibiting decomposition

Inactive Publication Date: 2018-11-23
NICHIBAN KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although pruritus in hemodialysis patients and patients with chronic liver disease is not a life-threatening complication, it often occurs during sleep and causes sleep disturbances, etc., causing obstacles in daily life, which affects the quality of life (QOL) of dialysis patients. not trivial complication of maintenance
[0004] In the administration method of medicament, oral medicine is the most general method, but the oral medicine of nafuraphine is considered to have side effects such as insomnia, constipation and drowsiness, because the occurrence rate of side effect increases with the increase of dosage, so it is considered that Temporary rise in blood levels of nafurine may be the cause of side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] For the styrene-isoprene-styrene block copolymer (SIS; trade name "SIS5002", manufactured by JSR Corporation) 7.97 wt%, styrene-isoprene-styrene block copolymer as the elastomer Segment copolymer (SIS; trade name "Quintac3520", manufactured by Nippon Zeon Co., Ltd.) 23.9 wt%, terpene resin as the tackifier (trade name "YS RESINPX1150N", manufactured by Yasuhara Chemical Co., Ltd.) 19.1 wt% , 48.48wt% of liquid paraffin (trade name "HICALL M352", manufactured by Kaneda Corporation) as the softener, 0.25 wt% of Nafuraphine hydrochloride dissolved in an appropriate amount of methanol as the salt of Nafuraphine wt%, and 0.3 wt% of monoethanolamine as the desalting agent, an organic solvent (toluene) was added so that the solid content became 50 wt%, and mixed until uniform to prepare an adhesive composition. Next, the obtained pressure-sensitive adhesive composition was applied to a silicone-treated polyester film (average thickness 75 μm) as a cover material (release sheet...

Embodiment 2

[0157] In Example 1, patch 2 and patch agent product 2 and evaluate it.

Embodiment 3

[0159] In Example 1, instead of 19.1 wt% of "YS RESIN PX1150N" as a terpene resin, 19.1 wt% of "PINECRYSTAL KE-311 (ultra-light-colored rosin ester)" (manufactured by Arakawa Chemical Industry Co., Ltd.) as a rosin resin Except for using as the thickener, the patch 3 and the patch product 3 were produced and evaluated in the same manner as in Example 1.

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Abstract

This adhesive patch product is provided with a packaging bag and a nalfurafine-containing adhesive patch housed in the interior of the packaging bag, and obtains excellent nalfurafine stability over time as a result of being provided with a means for reducing the oxygen concentration and / or moisture content within the packaging bag.

Description

technical field [0001] The present invention relates to a patch product composed of a percutaneous absorption type patch and a packaging bag. Background technique [0002] As a compound for improving pruritus in patients with hemodialysis and improving pruritus in patients with chronic liver disease, nafuraphine, which is a κ-type opioid receptor agonist compound, is known. [0003] Although pruritus in hemodialysis patients and patients with chronic liver disease is not a life-threatening complication, it often occurs during sleep and causes sleep disturbances, etc., causing obstacles in daily life and becoming a problem that affects the QOL (Quality of Life, life) of dialysis patients. Quality) is an inescapable complication of maintenance. [0004] In the administration method of medicament, oral medicine is the most common method, but the oral medicine of nalfuraphine is considered to have side effects such as insomnia, constipation and drowsiness, because the occurrenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/10A61K9/70A61K31/485A61M37/00A61P17/04
CPCA61J1/10A61K9/70A61K31/485A61M37/00
Inventor 丰岛永实子
Owner NICHIBAN KK