A method for simultaneous detection of statin side chain and its enantiomer impurities
A technology of enantiomers and side chains, applied in the field of chemical analysis, achieves the effect of simple method, improved resolution and short derivatization time
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[0025] Side chain I is commonly used as the side chain of rosuvastatin, pitavastatin, fluvastatin, etc. There are four isomers, the structure is as follows, Ia (side chain) and Ib are enantiomers of each other, Ic and Id It is the epimer of Ia, the configuration of Ia is the configuration required for the side chain in statin synthesis, and the other three are generally considered as impurities. The impurities in the side chain directly affect the impurities of the enantiomers and epimers of the final raw materials, and it is necessary to control them, first of all, a sensitive and accurate analysis method is required. According to its structural formula, it is an alcohol, and the response of the four isomers on the ultraviolet detector is very low, making it difficult to detect.
[0026]
[0027] It can be seen from the structural formula that the sample to be tested is a side chain alcohol, which has a very low response on the ultraviolet detector, and the response of the...
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