Method for extracting cannabidiol by using subcritical water extraction technology

A cannabidiol and subcritical water technology, applied in the chemical industry, can solve the problems of difficulty in realizing industrialized scale-up production, long reaction time, low efficiency, etc., and achieves avoiding oxidative denaturation and residual pollution of poor solvents, short reaction period and high efficiency The effect of extraction rate

Inactive Publication Date: 2018-12-04
凤阳县小岗村永和营养保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Supercritical extraction has the advantages of strong extraction capacity, high extraction rate, strong selectivity, and good product quality, but it also has disadvantages such as high cost, high energy consumption, and difficulty in achieving industrial scale-up production.
[0007] 3) wherein the technology in the existing cannabidiol extra

Method used

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  • Method for extracting cannabidiol by using subcritical water extraction technology
  • Method for extracting cannabidiol by using subcritical water extraction technology
  • Method for extracting cannabidiol by using subcritical water extraction technology

Examples

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Effect test

Embodiment 1

[0046] After sifting 10Kg of the mosaic leaves of the marijuana plant in the flowering stage, spread them flat in an oven for drying treatment at a temperature of 100-130°C for 2-3 hours until the water content of the hemp mosaic leaves is less than 6%. Then add it into the pulverizer and grind it until the particle size is 10-20 mesh. The dried and pulverized marijuana flowers and leaves are divided into filter bags, placed in the closed extraction tank of the subcritical water extraction device, and pure water is added at a material-to-liquid ratio of 1:10 (W / V), and extracted at a temperature of 374 ° C. Extract under the subcritical state with a pressure of 21.7MPa for 30 minutes, repeat the extraction three times, filter to separate the waste residue and the aqueous solution, and combine the extracts. The extracted solution obtained above was heated under reduced pressure, and the excess pure water was evaporated to dryness to obtain a concentrated solution of cannabidiol...

Embodiment 2

[0048] After screening 100Kg of the mosaic leaves of cannabis plants in the stage of flowering, spread them flat in an oven for drying treatment at a temperature of 100-130°C for 3-3.5 hours until the water content of the cannabis flowers and leaves is less than 6%. Then add it into the pulverizer and grind it until the particle size is 10-20 mesh. The dried and pulverized marijuana flowers and leaves are divided into filter bags, placed in the closed extraction tank of the subcritical water extraction device, and pure water is added at a material-to-liquid ratio of 1:10 (W / V), and extracted at a temperature of 374 ° C. Extract under the subcritical state with a pressure of 21.7MPa for 40 minutes, repeat the extraction three times, filter to separate the waste residue and the aqueous solution, and combine the extracts. The extract obtained above was heated under reduced pressure, and the excess pure water was evaporated to dryness to obtain a concentrated solution of cannabidi...

Embodiment 3

[0050] After sifting 10Kg of the mosaic leaves of the cannabis plant in the flowering stage, spread them flat in an oven for drying treatment at a temperature of 100-130°C for 2.5-3 hours until the water content of the cannabis flowers and leaves is less than 6%. Then add it into the pulverizer and grind it until the particle size is 10-20 mesh. Put the dried and pulverized marijuana flowers and leaves in a closed container, add 95% ethanol according to the ratio of material to liquid 1:10 (W / V), soak and extract 3 times, each time for 2-3 hours, filter to separate the waste residue from the aqueous solution , combined extracts. Heat the extract obtained above under reduced pressure, evaporate the excess pure water to dryness and volatilize, and obtain a concentrated solution of cannabidiol; the content of CBD in the paste is 25.0%. Add the concentrated solution of cannabidiol to pure After diluting with water, use a chromatographic column to carry out gradient elution on the...

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Abstract

The invention provides a method for extracting cannabidiol and belongs to the technical field of chemical industry. The method comprises the steps: carrying out subcritical water extraction on dried,ground and smashed hemp plants by using a subcritical water extraction means; concentrating an extracting solution, removing impurities, and then, carrying out dilution; carrying out gradient elutionby using a chromatographic column; and concentrating and crystallizing a target eluant to obtain a cannabidiol product. A subcritical water extraction technology is adopted in an extraction process, and compared with a traditional process, the subcritical water extraction technology has the advantages that the extraction time is shortened, the yield is increased by 0.3%, meanwhile, the purity of the obtained CBD extract reaches up to 99.7%, and no chemical organic reagents are used, so that the method is environment-friendly, high in speed and efficiency and more beneficial to industrialization.

Description

technical field [0001] The invention relates to the technical field of chemical industry, in particular to a method for extracting cannabidiol by subcritical water extraction technology. Background technique [0002] Cannabis (Cannabis sativa Linn.) is an annual plant with important medicinal value, belonging to Magnoliopsida, Urticales, Cannabinaceae, Cannabis, also known as hemp, hemp , hemp, mountain silk hemp, jute and industrial hemp. Cannabis flowers and leaves to be bloomed contain rich physiologically active components including cannabinoids and non-cannabinoids, among which the number of cannabinoids and physiologically active components are relatively large. At present, there are more than 80 kinds of cannabinoids (CBs) isolated from cannabis, mainly including cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN) and cannabinoids. Cannabichromene (CBC), etc., among which cannabidiol (CBD) and tetrahydrocannabinol (THC) have the highest content, which ar...

Claims

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Application Information

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IPC IPC(8): C07C39/23C07C37/68C07C37/82C07C37/84
CPCC07C37/004C07C37/685C07C37/82C07C37/84C07C2601/16C07C39/23B01D11/0203
Inventor 时圣言
Owner 凤阳县小岗村永和营养保健品有限公司
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