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Extraction method for panax notoginseng saponins

The technology of a kind of Panax notoginseng saponins and its extraction method is applied in the field of extraction of Panax notoginseng saponins, which can solve the problems of affecting the total Panax notoginseng saponins, large consumption of organic solvents, complex extraction process, etc., and achieves the advantages of industrial production, low cost, and high-quality process. simple effect

Inactive Publication Date: 2018-12-07
四川奇格曼药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing methods for extracting notoginseng saponins mainly use methods such as alcohol extraction. During the extraction process, the consumption of organic solvents is large, and there are problems such as complex extraction process, low extraction rate, and solvent residues, which affect the yield of total notoginseng saponins.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The extraction method of Panax notoginseng total saponins comprises the following steps:

[0031] (1) Enzymolysis treatment: crush fresh Panax notoginseng into 10-20 mesh granular form, mix into Aspergillus niger with 0.2% mass of Panax notoginseng, Penicillium oxalicum exoglycosidase with 0.1% mass of Panax notoginseng, heat to a temperature of 65° C. with microwave, Under microwave power 500W, carry out enzymatic treatment for 2h;

[0032] (2) Soak the notoginseng after the enzymolysis treatment in water, add 3% citric acid by mass of notoginseng, heat and extract at a temperature of 65° C. for 12 hours, add water and citric acid to the filter residue again, filter to obtain the filtrate, and The secondary filtrates are combined to obtain the Panax notoginseng extract;

[0033] (3) After concentrating the obtained Panax notoginseng extract, pass the concentrated solution through a D101 macroporous resin chromatography column, wash with 5 times the column volume, elut...

Embodiment 2

[0038] The extraction method of Panax notoginseng total saponins comprises the following steps:

[0039] (1) Enzymolysis treatment: crush fresh Panax notoginseng into 10-20 mesh granular form, mix in Aspergillus niger with 0.1% mass of Panax notoginseng, Penicillium oxalicum exoglycosidase with 0.05% mass of Panax notoginseng, heat to a temperature of 55° C. with microwave, Carry out enzymatic hydrolysis treatment under microwave power 400W 4h;

[0040] (2) Soak the notoginseng after the enzymolysis treatment in water, add 1.5% citric acid by mass of notoginseng, heat and extract at a temperature of 65° C. for 8 hours, add water and citric acid to the filter residue again, filter to obtain the filtrate, and The secondary filtrates are combined to obtain the Panax notoginseng extract;

[0041] (3) After concentrating the obtained Panax notoginseng extract, pass the concentrated solution through a D101 macroporous resin chromatography column, wash with 5 times the column volume...

Embodiment 3

[0046] The extraction method of Panax notoginseng total saponins comprises the following steps:

[0047] (1) Enzymolysis treatment: crush fresh Panax notoginseng into 10-20 mesh granular form, mix into Aspergillus niger with 0.15% mass of Panax notoginseng, Penicillium oxalicum exoglycosidase with 0.05% mass of Panax notoginseng, heat to a temperature of 60° C. with microwave, Carry out enzymatic hydrolysis treatment under microwave power 500W 3h;

[0048] (2) Soak the notoginseng after the enzymolysis treatment in water, add 2.5% citric acid of the mass of notoginseng, heat and extract at a temperature of 65° C. for 8 hours, add water and citric acid to the filter residue again, filter to obtain the filtrate, and The secondary filtrates are combined to obtain the Panax notoginseng extract;

[0049] (3) After concentrating the obtained Panax notoginseng extract, pass the concentrated solution through a D101 macroporous resin chromatography column, wash with 5 times the column...

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Abstract

The invention provides an extraction method for panax notoginseng saponins. The extraction method comprises the following steps: enzymolysis treatment, aqueous extraction, macroporous resin adsorption, activated carbon adsorption and cation exchange resin adsorption, wherein citric acid is added for anti-oxidization in the step of aqueous extraction, so that the quality and yield of the product can be increased. The method adopts water as a solvent for digesting pseudo-ginseng and is beneficial to the reduction of residual organic solvent in the product.

Description

technical field [0001] The invention belongs to the field of chemical medicine extraction, and in particular relates to an extraction method of Panax notoginseng total saponins. Background technique [0002] Panax notoginseng has the effect of "raw and cooked tonic", that is, taking raw notoginseng can promote blood circulation and remove blood stasis, reduce swelling and relieve pain, and is effective in treating bruises and injuries; taking cooked notoginseng (fried raw notoginseng with chicken oil or other oils) Huang is the mature notoginseng), which can nourish blood and strengthen the body. Scientific research and clinical trials have proved that Panax notoginseng, like ginseng, contains nourishing ingredients such as tetracyclic triterpenes, and its content is higher than that of ginseng. The ketone compounds contained in Panax notoginseng can promote blood circulation, expand coronary arteries, reduce Cardiac oxygen consumption, reduce the workload of myocardial wor...

Claims

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Application Information

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IPC IPC(8): A61K36/258
CPCA61K36/258A61K2236/19A61K2236/331A61K2236/51A61K2236/55
Inventor 姚静张宪胡伟杨琴飞李豫俭曾奇祥
Owner 四川奇格曼药业有限公司
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