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Tremella uronic acid polysaccharide-Furong plum anthocyanin compound for colon-targeting delivery and preparation method thereof

A technology of Tremella uronic acid polysaccharide and colon targeting, which is applied in the field of food processing and can solve the problems of low bioavailability and the like

Active Publication Date: 2018-12-11
INST OF AGRI ENG TECH FUJIAN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of low direct oral bioavailability of anthocyanins and difficulty in exerting health effects in the lower digestive tract (especially the colon), the present invention provides a tremella uronic acid polysaccharide-hibiscus plum anthocyanin complex and Its preparation method can reduce the damage of gastrointestinal tract environment and digestive enzymes to anthocyanins, thereby improving the bioavailability of anthocyanins in the human body

Method used

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  • Tremella uronic acid polysaccharide-Furong plum anthocyanin compound for colon-targeting delivery and preparation method thereof
  • Tremella uronic acid polysaccharide-Furong plum anthocyanin compound for colon-targeting delivery and preparation method thereof

Examples

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Effect test

Embodiment 1

[0018] (1) Preparation of hibiscus plum anthocyanins: select fresh hibiscus plums that are eight or nine mature, free from diseases and insect pests, and have bright red flesh, wash, remove pits, slice, dry with hot air at 50°C until the water content is less than 12%, and then crush to obtain fruit powder; Take 100g of fruit powder, add 1500mL of 80vol.% ethanol solution with a pH value of 3.0, extract with 600W ultrasonic wave at 50°C for 30min, and then centrifuge at 4000rpm for 10min, the obtained supernatant is concentrated under reduced pressure at 50°C and 0.01MPa to remove ethanol and obtain anthocyanins Crude extract; then the obtained crude anthocyanin extract is purified with AB-8 macroporous resin, the resin is washed with distilled water, desorbed and eluted with 80vol.% ethanol solution, the eluate is concentrated in vacuo at 45°C to remove ethanol, and then vacuum Freeze-drying to obtain hibiscus plum anthocyanins whose anthocyanin content is 950mg / kg;

[0019] ...

Embodiment 2

[0023] (1) Preparation of hibiscus plum anthocyanins: select fresh hibiscus plums that are eight or nine mature, free from diseases and insect pests, and have bright red flesh, wash, remove pits, slice, dry with hot air at 50°C until the water content is less than 12%, and then crush to obtain fruit powder; Take 300g of fruit powder, add 4500mL of 80vol.% ethanol solution with a pH value of 3.0, extract with 600W ultrasonic wave at 50°C for 30min, and then centrifuge at 4000rpm for 10min, the obtained supernatant is concentrated under reduced pressure at 50°C and 0.01MPa to remove ethanol and obtain anthocyanins Crude extract; then the obtained crude anthocyanin extract is purified with AB-8 macroporous resin, the resin is washed with distilled water, desorbed and eluted with 80vol.% ethanol solution, the eluate is concentrated in vacuo at 45°C to remove ethanol, and then vacuum Freeze-drying to obtain hibiscus plum anthocyanins whose anthocyanin content is 837mg / kg;

[0024] ...

Embodiment 3

[0028](1) Preparation of hibiscus plum anthocyanins: select fresh hibiscus plums that are eight or nine mature, free from diseases and insect pests, and have bright red flesh, wash, remove pits, slice, dry with hot air at 50°C until the water content is less than 12%, and then crush to obtain fruit powder; Take 50g of fruit powder, add 750 mL of 80vol.% ethanol solution with a pH value of 3.0, extract with 600W ultrasonic wave at 50°C for 30min, and then centrifuge at 4000rpm for 10min. Crude extract; then the obtained crude anthocyanin extract is purified with AB-8 macroporous resin, the resin is washed with distilled water, desorbed and eluted with 80vol.% ethanol solution, the eluate is concentrated in vacuo at 45°C to remove ethanol, and then vacuum Freeze-drying to obtain hibiscus plum anthocyanins whose anthocyanin content is 890mg / kg;

[0029] (2) Preparation of tremella uronic acid polysaccharide extract: Wash the discarded tremella fungus base, take 100g of tissue cru...

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Abstract

The invention discloses a tremella uronic acid polysaccharide-Furong plum anthocyanin compound for colon-targeting delivery and a preparation method thereof. The compound is a compound obtained by loading Furong plum anthocyanin on tremella uronic acid polysaccharide and covering through ethyl cellulose. The compound has a colon-targeting releasing effect and can prevent conditions that the Furongplum anthocyanin is in contact with high-acidity acid in stomachs, an intestine has a relatively alkaline environment and the Furong plum anthocyanin is contact with bile salt so that the Furong plumanthocyanin is damaged; the retention rate of the anthocyanin in colons reaches 90 percent or more, so that the compound can directly act on colon cells to realize the health-care effects of regulating an intestinal flora structure, maintaining intestinal microorganism balance and preventing and treating colon disease and the like; and the technical difficulties that the bioavailability is low when the anthocyanin is directly orally taken and a healthy effect is difficult to express in the colons are overcome.

Description

technical field [0001] The invention belongs to the technical field of food processing, and in particular relates to a colon-targeted delivery tremella uronic acid polysaccharide-hibiscus plum anthocyanin compound and a preparation method thereof. Background technique [0002] Microbes in the human gut are involved in many human physiological activities and metabolism, including food digestion, mineral absorption, regulation of immune response, they can affect body weight and digestion ability, and resist infection and autoimmune disease risk. Changes in the structure or quantity of intestinal microbial communities are closely related to human health problems such as obesity, diabetes, hypertension, and hyperlipidemia. The colon is the digestive site with the most intestinal flora, and colonic microbes are closely related to the metabolism and absorption of nutrients and functional substances in the colon. The colon-targeted delivery system can carry and release functional ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L33/105
CPCA23V2002/00A23L33/105A23L33/125A23V2200/32A23V2250/2104
Inventor 李怡彬陈君琛赖谱富吴俐汤葆莎
Owner INST OF AGRI ENG TECH FUJIAN ACAD OF AGRI SCI
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