Novel temperature-sensitive hydrogel-like sealant and lubricant for dental implant system

A temperature-sensitive hydrogel and implant system technology, which is applied in the field of new temperature-sensitive hydrogel-like sealants and lubricants, can solve the problem that the torque cannot be fully converted into preload, the friction coefficient of Teflon coating is small, and the stability of the abutment is affected. and other problems to achieve the effect of reducing micro-leakage, reducing growth space, and reducing the occurrence of tissue inflammation

Active Publication Date: 2018-12-18
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Under normal circumstances, the manufacturers of implant systems used in clinic have specified torque to ensure sufficient preload between the implant abutment, but due to the friction between the interface between the implant and the abutment, the torque cannot be fully converted into Preload, part of the torque is used to overcome the friction, if the friction is too large, it will lead to insufficient preload, thus affecting the stability of the abutment
[0005] In order to improve the stability of implant abu

Method used

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  • Novel temperature-sensitive hydrogel-like sealant and lubricant for dental implant system
  • Novel temperature-sensitive hydrogel-like sealant and lubricant for dental implant system
  • Novel temperature-sensitive hydrogel-like sealant and lubricant for dental implant system

Examples

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Embodiment 1～3

[0026] The chitosan temperature-sensitive hydrogel described in Examples 1 to 3 is prepared from chitosan, sodium β-glycerophosphate and povidone-iodine, and is applied to a dental implant system. The specific preparation process includes the following steps:

[0027] 1) The chitosan powder of 320mg is dissolved in 9ml (0.18M) glacial acetic acid and obtains chitosan solution, high temperature and high pressure sterilization; bacteria water) to obtain β-sodium glycerophosphate and povidone-iodine solution;

[0028] 2) Prepare 1ml thermosensitive hydrogel:

[0029] ①Mix a certain volume of chitosan solution and 100 μl povidone-iodine solution in a sterile EP tube, stir well to obtain solution A:

[0030] ②Solution A and a certain volume of β-glycerophosphate sodium solution (placed in a sterile EP tube) were bathed in ice water for 15 minutes at the same time;

[0031] ③Sodium β-glycerophosphate solution is slowly added to solution A drop by drop while stirring in an ice-wate...

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Abstract

The invention belongs to the field of biomedical technology, and in particular relates to a temperature-sensitive hydrogel-like sealant and lubricant for a dental implant system. The preparation method of the temperature-sensitive hydrogel-like sealant and lubricant is as follows: dissolving chitosan powder in glacial acetic acid to obtain a chitosan solution, and sterilizing the chitosan solutionat high temperature and pressure; dissolving sodium beta-glycerophosphate and povidone iodine in filtered and sterilized tri-distilled water separately to obtain a sodium beta-glycerophosphate solution and a povidone iodine solution; mixing the chitosan solution and the povidone iodine solution, and stirring evenly to obtain a solution A; putting the solution A and the sodium beta-glycerophosphate solution in an ice-water bath simultaneously, then slowly dripping the sodium beta-glycerophosphate solution into the solution A under stirring conditions, fully stirring uniformly the solution in the ice-water bath to obtain a liquid temperature-sensitive hydrogel. The preparation method is simple, low in production cost, and convenient for popularization and use.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a novel temperature-sensitive hydrogel-like sealant and lubricant for dental implant systems. Background technique [0002] As an effective way to restore missing teeth, oral implant technology is being used more and more around the world. Compared with traditional restoration methods, it has higher chewing efficiency and more beautiful appearance. However, in long-term clinical practice, complications related to dental implants also occur from time to time, such as peri-implantitis, loosening of implanted dentures, and fracture of implant abutments. [0003] The occurrence of peri-implantitis is mostly related to the accumulation and reproduction of bacteria around the implant. The implant and the abutment are not tightly combined, and there is a micro gap of 2-40 μm between them. Bacteria in the oral cavity can enter the micro-gap to grow and reproduce, secret...

Claims

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Application Information

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IPC IPC(8): A61K6/00C08J3/075C08L5/08C08L39/06
CPCA61K6/30A61K6/69C08J3/075C08J2305/08C08J2439/06C08L5/08
Inventor 蔡新杰蒋滔曹晓晓马克娜
Owner WUHAN UNIV
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