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Preparation method for hydroxyapatite nanowire

A hydroxyapatite and nanowire technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of difficult to achieve large-scale production, high energy consumption, cumbersome processes, etc. High, simple process effect

Active Publication Date: 2018-12-18
SHENZHEN SENIOR TECH MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the synthesis of hydroxyapatite nanowires, there are mainly aqueous phase synthesis methods, high temperature solid phase synthesis methods and template synthesis methods, but these synthesis methods have the problems of cumbersome processes, high energy consumption, and difficulty in large-scale production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The invention provides a method for preparing hydroxyapatite nanowires, comprising the following steps:

[0034] Prepare water-soluble calcium salt solution and water-soluble phosphate solution;

[0035] Measure the water-soluble calcium salt solution and the water-soluble phosphate solution, mix quickly, add graphene oxide nanosheets under the condition of stirring, adjust the pH, obtain the mixed solution, stir, the water-soluble calcium salt in the water-soluble calcium salt solution and The molar ratio of the water-soluble phosphate in the water-soluble phosphate solution is (0.1-2.5):1, such as 0.1:1, 0.2:1, 0.3:1, 0.4:1, 0.5:1, 0.6:1, 0.7:1, 0.8:1, 0.9:1, 1:1, 1.2:1, 1.4:1, 1.5:1, 1.8:1, 2:1, 2.2:1, 2.5:1, etc.;

[0036] Carrying out microwave synthesis reaction to described mixed solution;

[0037] After centrifugation, a precipitate is obtained, which is hydroxyapatite nanowires.

[0038] In some specific embodiments, the time for the microwave synthesis reac...

Embodiment 1

[0056] Prepare 30mmol / L disodium hydrogen phosphate solution, 60mmol / L calcium chloride solution and 0.2 mmol / L sodium hydroxide solution for subsequent use;

[0057] Accurately measure 50mL of disodium hydrogen phosphate solution and 20mL of calcium chloride solution with a graduated cylinder, and pour them into two 100mL beakers respectively;

[0058] The solutions in the two beakers were quickly mixed, and under stirring conditions, 20 g of graphene oxide nanosheets were added, and the pH was quickly adjusted to 10 with sodium hydroxide solution to obtain a mixed solution;

[0059] After stirring for 1 hour, the mixed solution was put into a microwave synthesis kettle, and the microwave power was adjusted to 400W, and the microwave reaction was 30min;

[0060] After the reaction is finished, the reacted solution is centrifuged at a speed of 4000 r / min, the graphene oxide nanosheets remain in the solution, and the obtained precipitates are hydroxyapatite nanowires.

[0061]...

Embodiment 2

[0064] Prepare 30mmol / L sodium dihydrogen phosphate solution, 60mmol / L calcium chloride solution and 0.2 mmol / L hydrochloric acid solution for subsequent use;

[0065] Accurately measure 100mL of disodium hydrogen phosphate solution and 50mL of calcium chloride solution with a graduated cylinder, and pour them into two 100mL beakers respectively;

[0066] The solutions in the two beakers were quickly mixed, and under stirring conditions, 10 g of graphene oxide nanosheets were added, and the pH was quickly adjusted to 11 with hydrochloric acid solution to obtain a mixed solution;

[0067] After stirring for 1 hour, the mixed solution was put into a microwave synthesis kettle, and the microwave power was adjusted to be 600W, and the microwave reaction was 30min;

[0068] After the reaction, the reacted solution was centrifuged at a speed of 1000r / min, the graphene oxide nanosheets were left in the solution, and the obtained precipitate was hydroxyapatite nanowires.

[0069] The...

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Abstract

The invention provides a preparation method for a hydroxyapatite nanowire. The preparation method comprises the following steps: weighing a water-soluble calcium salt solution and a water-soluble phosphate solution, carrying out mixing, adding graphene oxide nanosheets, adjusting a pH value to obtain a mixed solution, and then carrying out stirring, wherein a molar ratio of a water-soluble calciumsalt in the water-soluble calcium salt solution to water-soluble phosphate in the water-soluble phosphate solution is (0.1-2.5): 1; and subjecting the mixed solution to a microwave synthesis reactionand carrying out centrifugal separation to obtain the hydroxyapatite nanowire. The preparation method has the advantages of simple process, low energy consumption and capacity of realizing large-scale production; and the prepared nanowire is regular in shape and adjustable in size.

Description

technical field [0001] The invention relates to a nanometer material and a preparation method thereof, in particular to a preparation method of a hydroxyapatite nanowire. Background technique [0002] Hydroxyapatite is the main inorganic component of vertebrate bones and teeth. It has good biological activity, biocompatibility and biodegradability. It can form a strong chemical bond with human hard tissues. It can be combined with human bone after implantation Realizing osseointegration and gradually being replaced by human bone is one of the research hotspots of biological hard tissue repair and replacement materials. However, general hydroxyapatite bioceramics have poor mechanical properties and cannot be used in weight-bearing parts of the human body, which greatly limits the clinical use of this material. Studies have found that one-dimensional nano-sized materials, such as nanowires, nanorods, and nanotubes, can significantly improve the mechanical properties of cerami...

Claims

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Application Information

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IPC IPC(8): C01B25/32
CPCC01B25/32C01P2004/16C01P2004/61C01P2004/62C01P2004/64
Inventor 王艳杰黄晓玲杨雪梅
Owner SHENZHEN SENIOR TECH MATERIAL