A kind of nickel-antifungal drug functionalized polyacid complex, preparation method and application
An antifungal drug and functionalization technology, which is applied in the direction of nickel organic compounds, organic chemical methods, chemical instruments and methods, etc., can solve the problems of cumbersome operation, high price, hindering the development of small biological molecule detection, etc., and achieve good sensing performance Effect
Active Publication Date: 2020-11-03
JINING UNIV
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Problems solved by technology
Fluorescence and electrochemical detection of H 2 o 2 There are also some reports on biosensors, but most of these detection methods have the disadvantages of cumbersome operation, high price, and detection components are easily disturbed by external conditions, which have seriously hindered the development of small biological molecule detection.
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Embodiment 1
[0030] A preparation method of a nickel-antifungal drug functionalized polyacid complex, specifically comprising the following steps:
[0031] Accurately weigh 300 mg of H on an analytical balance 4 SiW 12 o 40 , 55mg of Ni(NO 3 ) 2 , 60mg of fluconazole, 36mg of NH 4 VO 3 and 30 mg of polyethylene glycol 1500, add the above-mentioned weighed raw materials into 10 mL of distilled water, stir at room temperature to make it fully dissolve, and continue stirring for 1 hour after it is fully dissolved to obtain a pre-reaction solution;
[0032] Adjust the pH value of the pre-reaction solution to 2.5 with a nitric acid solution with a concentration of 1mol / L, then place it in a stainless steel high-pressure reactor, and crystallize at a constant temperature at 170°C for 4 days. After the crystallization is completed, cool the reaction solution to room temperature, and then filter The filtrate was removed, and the filter residue was washed with water and dried naturally to obt...
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The invention discloses a nickel-antifungal drug functionalized polyacid complex and a preparation method thereof. The preparation method comprises the following steps: dissolving H4SiW12O40, Ni(NO3)2, fluconazole, NH4VO3 and a surfactant into distilled water to obtain a pre-reaction solution; adding the pre-reaction solution in a reaction kettle, and crystallizing at a constant temperature of 170DEG C for 4 days to obtain the nickel-antifungal drug functionalized polyacid complex. In the invention, fluconazole is taken as a functional molecule to shear, modify or bridge Keggin-type polyacidby coordination bond interaction in the presence of nickel ions, thereby preparing the functionalized polyacid complex; an ultraviolet spectrophotometer is used to study the decomposition catalytic activity of the complex as horseradish peroxidase on H2O2, and the results show that the complex has good H2O2 sensing performance, and the detection range for H2O2 is 0.1 to 90 micromole.L<-1>, and theminimum detection limit is 0.13 micromole.L<-1>.
Description
technical field [0001] The invention belongs to the technical field of preparing novel biosensors, and in particular relates to a nickel-antifungal drug functionalized polyacid compound, a preparation method and an application. Background technique [0002] Small biological molecules play a vital role in the metabolic process in the human body and even the entire life process, and their content directly affects the health of the human body. For example, when H in the body 2 o 2 When it exceeds a certain amount, it will break the redox balance in the body or cause the body's antioxidant capacity to be low, which will cause oxidative stress and even cause certain damage to some tissues, and this damage will accumulate over time and induce Serious diseases such as diabetes, arteriosclerosis, cancer, etc. Therefore, the detection of small biological molecules has become an important standard to measure the living environment, physical quality and health status of human beings...
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IPC IPC(8): C07F15/04G01N21/33
CPCC07B2200/13C07F15/045G01N21/33
Inventor 沙靖全钟晓华刘国栋
Owner JINING UNIV