Cascade impactor plate coating

A sampler, cascading technology, used in instruments, sampling, sampling devices, etc.

Inactive Publication Date: 2018-12-21
KIND CONSUMER LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Time-of-flight analyzers can also measure this variable, but must be calc

Method used

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  • Cascade impactor plate coating
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0114] The invention will now be described with reference to the following non-limiting examples.

[0115] A cascade impactor sampler according to the invention is arranged to determine the particle size distribution of an aerosol comprising nicotine.

[0116] The detailed settings of this device are as follows. Use as described in detail above and as Figure 4A and Figure 4B The Copley Scientific NGI indicated in was used for this experiment. A solution of isopropanol was added to the sample collection stage of the NGI and an aerosol including nicotine was introduced into the device. Subsequently, samples collected at various levels in the NGI were collected and analyzed using gas chromatography.

[0117] diluent preparation

[0118] A 1 mg / mL stock solution of heptadecane in isopropanol (IPA) was prepared. Weigh 100 mg of heptadecane into a 100 mL volumetric flask. The volumetric flask was made up to volume with IPA.

[0119] A 1 L solution of heptadecane in IPA (...

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PUM

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Abstract

The present invention relates to a cascade impactor for measuring particle size distribution of an aerosol comprising nicotine, the cascade impactor comprising: an induction port for receiving an inhaler; and at least one sample collection stage comprising a nozzle assembly and a collection means; wherein the collection means of at least one sample collection stage is coated with isopropyl alcohol.

Description

technical field [0001] The present invention relates to cascaded impactors and methods of use thereof. Background technique [0002] Cascade impactors have been used for several years to determine the aerodynamic size of aerosol particles. The aerodynamic particle size of inhalation products is important because particle size directly affects the local deposition of aerosols in the lungs and respiratory tract. [0003] Therefore, the measurement of the particle size distribution of aerosol particles is important in the development and manufacture of inhaler products that generate aerosols for delivering substances to the lungs or airways of a user. Several suitable techniques for measuring the particle size of such aerosol particles have been developed. These techniques include, for example, particle time-of-flight spectroscopy, laser diffraction, phase Doppler particle sizing, and inertial techniques such as cascade shock. [0004] Deposit the The fraction of the dose i...

Claims

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Application Information

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IPC IPC(8): G01N15/02G01N1/22B01D1/00B01B1/00A61K31/465B01D45/08
CPCG01N2015/0026A61K31/465G01N2001/2223G01N2015/0261G01N15/0255G01N1/2208B01D53/025G01N30/06
Inventor A·J·西尔科克
Owner KIND CONSUMER LIMITED
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