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Traditional Chinese medicine preparation for preventing and treating coronary artery injury of kawasaki disease

A traditional Chinese medicine preparation and coronary artery technology, applied in the field of medicine, can solve problems such as low clinical efficacy and liver damage, and achieve the effects of reasonable formula compatibility, small side effects, and prevention of thrombosis.

Inactive Publication Date: 2018-12-28
THE PEOPLES HOSPITAL SHAANXI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because children with Kawasaki disease need to take it for a long time, many children with coronary aneurysm need to take it for life, but the clinical effect is not high and it will cause toxic side effects such as bleeding and liver damage.
At present, there is no new alternative treatment plan at home and abroad; however, the clinical efficacy of oral Chinese medicine preparations is clear without bleeding and other side effects
The study of traditional Chinese medicine on coronary artery damage in Kawasaki disease has not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Male, 9 years old, suffered from Kawasaki disease a year ago with 8mm enlarged left coronary artery. During hospitalization, he was infused with high-dose intravenous immunoglobulin (IVIG) 2ooomg / Kg / day, and has been taking aspirin 3mg / Kg / day after discharge Day, warfarin and low molecular weight heparin were taken orally for half a year, but the coronary lesions remained unchanged and epistaxis occurred more than 10 times, and then 9 grams of kudzu root each time, 6 grams of salvia miltiorrhiza and 6 grams of Chuankao were used for a total of more than 20 days (daily One dose decocted in water twice a day). After examination, the coronary artery disease was better than before, and no bleeding such as epistaxis occurred within half a year.

Embodiment 2

[0018] Male, 6 years old. Half of me suffered from coronary aneurysm of Kawasaki disease before (right coronary artery A expanded into a tumor-like expansion in the middle section, and the left 7th coronary artery was dilated and showed a tumor-like expansion). The volume of the left adrenal gland increased. Pirin, cyclosporine, warfarin and other drugs were ineffective. Then add the above-mentioned three traditional Chinese medicines (dose as above), 20 doses, 1 dose per mouth). Now the condition is stable, and no symptoms such as four occur. Before taking this traditional Chinese medicine, symptoms such as fever and hypocardia occurred after abdominal administration.

Embodiment 3

[0020] Male, 7 years old. He suffered from coronary aneurysm of Kawasaki disease one year ago. During hospitalization, he was infused with large doses of gamma balls and took ascorboid 3mg / kg / day, and warfarin 1~2mg (INR was kept at 2~3). However, the child recurred abdominal pain, vomiting and epistaxis, but the coronary aneurysm remained unchanged, and then began to take the above-mentioned three traditional Chinese medicines (the dosage and method were the same as above), and the above-mentioned symptoms did not occur again after 30 days of administration. Continued treatment follow-up.

[0021] The dosage range of traditional Chinese medicine Pueraria lobata is generally 9 grams per day.

[0022] <6 years old 6 g / day, 7-15 years old, 9 g / day. Salvia, generally 6 grams / day, <6 years old 3 grams / day, 7-15 years old, 6 grams / day. Chuanxiong, generally 6 grams / day, <6 years old, 3 grams / day, 7-15 years old, 6 grams / day.

[0023] The above three medicines are mixed, deco...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine preparation for preventing and treating coronary artery injury of a kawasaki disease. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 9 parts of root of kudzu vine, 6 parts of salviae miltiorrhizae and 6 parts of ligusticum wallichii. According to the pharmacological action of the primary chemical components of root of kudzu vine, salviae miltiorrhizae and ligusticum wallichii, the traditional Chinese medicine preparation is proved to have the functions of increasing coronary blood-flow volume, improving blood oxygen supply of myocardium, reducing the oxygen consumption of myocardium, improving microcirculation, reducing the surface activity of blood platelets, inhibiting platelet aggregation and preventing thrombogenesis. In traditional Chinese medicine, the root of kudzu vine is a medicine for relieving exterior disorder, and salviae miltiorrhizae and ligusticum wallichii are medicines for invigorating blood circulation and eliminating stasis. The root of kudzu vine, the salviae miltiorrhizae and the ligusticum wallichii are compatible. The preparation meets compatibility principles of various drugs. However, kawasaki disease is systematic vascular inflammation which primarily induces infantile coronary artery injury. The preparation facilitates the preventionand treatment of coronary artery disease of kawasaki disease. The traditional Chinese medicine preparation is reasonable in formula compatibility, remarkable in effect, low in cost, small in side effect, obvious in curative effect after clinical application and worth being popularized.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a traditional Chinese medicine preparation for preventing and treating coronary artery injury of Kawasaki disease. Background technique [0002] Kawasaki disease (Kawasaki disease, KD), also known as mucocutaneous lymph node syndrome (mucocutaneouslymphnodesyndrome, MCLS). Kawasaki disease is an acute febrile systemic vasculitis that mainly occurs in children under the age of five. The clinical features are mainly persistent fever, conjunctival hyperemia, oral mucositis of varying degrees, polymorphic rash, and hard swelling of hands and feet with fingertips. Desquamative, non-suppurative lymphadenitis; its pathogenesis is not yet clear, but it is considered to be a complex interaction of genetic factors, infection and immune domains, mainly leading to coronary aneurysms and vascular embolism, which has been the main cause of acquired heart disease in children cause. Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P29/00A61P9/14A61P9/10
CPCA61K9/0095A61K36/236A61K36/488A61K36/537A61K2236/331A61K2236/53A61P9/10A61P9/14A61P29/00A61K2300/00
Inventor 焦富勇王杰民穆志龙王菊艳冯建英严晓华李小红闫鲜鹏刘虹高娜李瑞韩田田韩伟田莉张晟
Owner THE PEOPLES HOSPITAL SHAANXI PROV
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