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A kind of compound and its preparation method and application in cosmetics

A compound and target compound technology, applied in the field of new compounds and their preparation, can solve the problems of uneven quality of whitening cosmetics

Active Publication Date: 2021-03-09
铂臻(广州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Whitening is the eternal beauty and skin care pursuit of Chinese women, but the quality of whitening cosmetics on the market varies. Most of the whitening cosmetics contain lead, mercury, triamcinolone acetonide, triamcinolone acetonide acetate, betamethasone, and betamethasone acetate. Esters, betamethasone valerate, clobetasol propionate and other heavy metals and hormones

Method used

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  • A kind of compound and its preparation method and application in cosmetics
  • A kind of compound and its preparation method and application in cosmetics
  • A kind of compound and its preparation method and application in cosmetics

Examples

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Effect test

Embodiment 1

[0061] (1) Weigh 1 kg of dried leaves of Paleum chinensis, crush them, add 10L of 75% ethanol for reflux extraction, and concentrate the extract to obtain the crude extract;

[0062] (2) The crude extract extract was dispersed in 1L of water, extracted three times with an equal volume of chloroform, collected the chloroform extract, and concentrated to obtain the chloroform extract;

[0063] (3) Extract the extract with chloroform, separate it with a silica gel column, first elute with chloroform-methanol (50:1) for 10 column volumes, discard the eluent, and then use chloroform-methanol ( 20:1) to elute 10 column volumes, collect the eluate, and concentrate it into an extract;

[0064] (4) The extract obtained in step (3) is further separated by preparative high performance liquid chromatography, wherein the high performance liquid chromatography conditions are: C18 chromatographic column, the mobile phase is 75% methanol for elution, and the eluent is recovered. That is, the...

Embodiment 2

[0066] ((1) Weigh 1 kg of dried leaves of Paleopsis chinensis, crush them, add 10L of 75% ethanol for reflux extraction, and concentrate the extract to obtain the crude extract;

[0067] (2) The crude extract extract was dispersed in 1L of water, extracted three times with an equal volume of chloroform, collected the chloroform extract, and concentrated to obtain the chloroform extract;

[0068] (3) Extract the extract with chloroform, separate it with a silica gel column, first elute with chloroform-methanol (50:1) for 10 column volumes, discard the eluent, and then use chloroform-methanol ( 20:1) to elute 10 column volumes, collect the eluate, and concentrate it into an extract;

[0069] (4) The extract obtained in step (3) is further separated by preparative high performance liquid chromatography, wherein the high performance liquid chromatography conditions are: C18 chromatographic column, the mobile phase is 75% methanol for elution, and the eluent is recovered. That is,...

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PUM

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Abstract

The invention discloses a new compound and its preparation method and application in cosmetics. The structural formula of the compound is as follows: the compound inhibits the synthesis of melanin by inhibiting the activity of tyrosinase, and exerts the effect of whitening at the same time , non-phototoxic, can be used to prepare cosmetics.

Description

technical field [0001] The invention belongs to the technical field of medicine and cosmetics, and in particular relates to a new compound, its preparation method and its application in cosmetics. Background technique [0002] Whitening is the eternal beauty and skin care pursuit of Chinese women, but the quality of whitening cosmetics on the market varies. Most of the whitening cosmetics contain lead, mercury, triamcinolone acetonide, triamcinolone acetonide acetate, betamethasone, and betamethasone acetate. Esters, betamethasone valerate, clobetasol propionate and other heavy metals and hormones. Mercury can be absorbed through the skin and accumulate in the body. Long-term use of mercury-containing cosmetics will cause chronic poisoning and damage human organs such as kidneys. The "Safety and Technical Specifications for Cosmetics" (2015 Edition) stipulates that the limit of mercury is 1mg / kg (containing organic mercury except eye cosmetics with preservatives). Long-ter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A61K8/49A61Q19/02
CPCA61K8/4973A61K2800/782A61Q19/02C07D493/04
Inventor 王培战
Owner 铂臻(广州)生物科技有限公司