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A biodegradable black phosphorus-based radiosensitizer and its preparation method and application

A biodegradable and sensitizing agent technology, applied in the field of medicine, can solve the problem of inability to completely eradicate tumor cells, and achieve the effects of stability in water, improved stability, and low biological toxicity

Active Publication Date: 2020-03-17
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during radiotherapy, due to the hypoxic environment of the tumor, radiotherapy alone cannot completely eradicate tumor cells, but instead makes the tumor resistant and insensitive to X-rays.

Method used

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  • A biodegradable black phosphorus-based radiosensitizer and its preparation method and application
  • A biodegradable black phosphorus-based radiosensitizer and its preparation method and application
  • A biodegradable black phosphorus-based radiosensitizer and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation method of black phosphorus-based radiosensitizer comprises the steps:

[0046] (1) Disperse the black phosphorus nanosheets in N-methylpyrrolidone, and prepare a black phosphorus nanosheet N-methylpyrrolidone solution with a concentration of 20 μg / mL;

[0047](2) dissolving bismuth nitrate pentahydrate in ethylene glycol solution, preparation concentration is the ethylene glycol solution of bismuth nitrate pentahydrate (bismuth salt solution must be freshly prepared) of 25mM;

[0048] (3) Get the black phosphorus nanosheet N-methylpyrrolidone solution obtained in 21mL of step (1), then add the ethylene glycol solution of bismuth nitrate pentahydrate obtained in 3.5mL of step (2), mix well and place in room temperature environment Stand in the medium for 3 hours, and centrifuge at 12,000 rpm for 15 minutes. The obtained precipitate is black phosphorus nanosheets modified by bismuth trioxide quantum dots, denoted as Bi 2 o 3 @BP.

Embodiment 2

[0050] The preparation method of black phosphorus-based radiosensitizer comprises the steps:

[0051] (1) Disperse the black phosphorus nanosheets in N-methylpyrrolidone, and prepare a black phosphorus nanosheet N-methylpyrrolidone solution with a concentration of 10 μg / mL;

[0052] (2) bismuth acetate is dissolved in ethylene glycol solution, and preparation concentration is the ethylene glycol solution of bismuth acetate of 20mM (bismuth salt solution must be freshly prepared);

[0053] (3) Get 21mL of the black phosphorus nanosheet N-methylpyrrolidone solution obtained in step (1), then add 2mL of the ethylene glycol solution of bismuth acetate obtained in step (2), mix evenly and place it in a static environment at 80°C Set aside for 0.5 hours, and centrifuge at 12000 rpm for 15 minutes, and the obtained precipitate is black phosphorus nanosheets modified with bismuth trioxide quantum dots.

Embodiment 3

[0055] The preparation method of black phosphorus-based radiosensitizer comprises the steps:

[0056] (1) Disperse black phosphorus nanosheets in 1,3-dimethyl-2-imidazolidinone, and prepare black phosphorus nanosheets 1,3-dimethyl-2-imidazolidinone solution with a concentration of 50 μg / mL ;

[0057] (2) Dissolve bismuth acetate in N-methylpyrrolidone solution, and prepare an N-methylpyrrolidone solution of bismuth acetate with a concentration of 8mM (the bismuth salt solution must be freshly prepared);

[0058] (3) Get the black phosphorus nanosheet 1,3-dimethyl-2-imidazolinone solution obtained in 21mL step (1), then add the N-methylpyrrolidone solution of bismuth acetate obtained in 21mL step (2) , after mixing evenly, let it stand at 4°C for 8 hours, and centrifuge at 12,000 rpm for 15 minutes, and the obtained precipitate is black phosphorus nanosheets modified with bismuth trioxide quantum dots.

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Abstract

The invention discloses a biodegradable black phosphorus-based radiotherapy sensitizer and a preparation method and application thereof. The preparation method of the biodegradable black phosphorus-based radiotherapy sensitizer comprises the following steps of adding a soluble bismuth salt solution into a black phosphorus nanosheet solution, standing for 0.5h or more, and centrifuging, so as to obtain the black phosphorus-based radiotherapy sensitizer, wherein the mass ratio of the bismuth salt to the black phosphorus nanosheet is (0.1 to 1.0):1.0. The prepared black phosphorus-based radiotherapy sensitizer can be used for preparing anti-tumor medicines, and the medicines are jointly used with an X-ray radiotherapy method, so as to reach better anti-tumor function. The biodegradable blackphosphorus-based radiotherapy sensitizer has the advantages that the large-scale preparation of the biodegradable black phosphorus-based X-ray power-therapy photo-sensitizer is realized; the foundation is laid for application in fields of photoelectrical devices, solar batteries, lithium batteries, biomedicines and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a biodegradable black phosphorus-based radiotherapy sensitizer and its preparation method and application. Background technique [0002] Photodynamic therapy is a new disease treatment technology, which is a cold chemical reaction that only needs photosensitizers, oxygen and light. Light excites the photosensitizer, and the photosensitizer transfers energy to the surrounding oxygen, thereby generating highly active singlet oxygen, killing or damaging cancer cells to achieve the purpose of treatment. [0003] Compared with traditional radiotherapy, photodynamic therapy has received extensive attention and research in recent years due to its advantages of low invasiveness, low toxicity, and no drug resistance. The current photosensitizer needs to be excited by visible light or near-infrared light, but the penetration depth of visible light or near-infrared light is extremely li...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/42A61P35/00
Inventor 陈填烽喻学锋黄浩贺利贞
Owner JINAN UNIVERSITY