Theanyl amino acid benzyl ester modified curcumin, its synthesis, activity and application

A technology of oxyacetyl theanyl and oxyacetyl benzyl ester group, which is applied to 1--7--1,6-heptadiene-3,5-dione, and the application in the preparation of antitumor drugs and anti-inflammatory drugs It can solve the problems of unsatisfactory clinical efficacy of tumor chemotherapy, no anti-inflammatory effect, and influence on the effect of chemotherapy.
CN109134598BActive Publication Date: 2021-10-26CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Publication Date
2021-10-26

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Abstract

The invention discloses 1-(4-hydroxyl-3-methoxyphenyl)-7-(4-oxyacetyltheanyl-AA-OBzl-3-methoxyphenyl)-1,6 -Heptadiene-3,5-dione (where AA is selected from L-Lys residues, L-Asn residues, L-Pro residues, L-Gln residues, L-Ser residues and L-Thr residues residues), disclose their preparation method, disclose their anti-tumor growth activity, and disclose their anti-inflammatory activity, thus the present invention discloses their application in the preparation of anti-tumor drugs and anti-inflammatory drugs.
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Description

technical field

[0001] The present invention relates to 1-(4-hydroxy-3-methoxyphenyl)-7-(4-oxoacetyltheanyl-AA-OBzl-3-methoxyphenyl)-1,6-heptadiene -3,5-diketone (where AA is selected from L-Lys residues, L-Asn residues, L-Pro residues, L-Gln residues, L-Ser residues and L-Thr residues). It relates to their preparation method, their anti-tumor growth activity, and their anti-inflammatory activity, so the present invention relates to their application in the preparation of anti-tumor drugs and anti-inflammatory drugs. The invention belongs to the field of biomedicine. Background technique

[0002] Malignant tumors are a global problem that seriously endangers human health. Cancer patients are mostly in the middle and late stages when they are discovered. The main treatment methods are radiotherapy and chemotherapy. Chemotherapy is the main treatment for malignant tumors in the middle and late stages. However, inflammation during chemotherapy can assist tumor growth and ser...

Claims

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