Method for building 2-(2-furyl)-1,3,4-oxadiazole in one step from DMF as carbon source

A furyl and oxadiazole technology, applied in the fields of cell biology, medicine, and materials, can solve the problems of toxic chemical reagents, and achieve the effects of easy-to-obtain reaction raw materials, mild reaction conditions, and novel synthetic routes

Inactive Publication Date: 2019-01-15
GUILIN UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

Its traditional synthetic methods often need to use toxic chemical reagents, such as phosphorus oxychloride, etc.

Method used

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  • Method for building 2-(2-furyl)-1,3,4-oxadiazole in one step from DMF as carbon source
  • Method for building 2-(2-furyl)-1,3,4-oxadiazole in one step from DMF as carbon source
  • Method for building 2-(2-furyl)-1,3,4-oxadiazole in one step from DMF as carbon source

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Embodiment 1

[0020] In a 25 mL test tube, add 0.2 mmol of 2-furyl hydrazide, 0.05 mmol of cuprous iodide, and 0.2 mmol of potassium persulfate, add DMF (N,N-dimethylformamide) as a solvent, and dissolve at 120 Stir at ℃. After TLC (thin layer chromatography) detection, the reaction solution was cooled to room temperature, the reaction solution was filtered, extracted, the filtrate was evaporated under reduced pressure to remove the solvent, and then separated and purified by column chromatography to obtain the target product 2-(2-furyl )-1,3,4-oxadiazole, the column chromatography eluent used was a mixture of petroleum ether:ethyl acetate with a volume ratio of 3:1, and the yield was 40%.

[0021] The structure of the product obtained in this embodiment is shown in figure 2 and image 3 .

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Abstract

The invention discloses a method for building 2-(2-furyl)-1,3,4-oxadiazole in one step from DMF (N,N-dimethyl formamide) as a carbon source. The method is characterized in that 2-furoyl hydrazide is taken as a raw material, and the DMF is taken as carbon source to build the 2-(2-furyl)-1,3,4-oxadiazole in one step through a carbon cyclization reaction. The method has the advantages of novel synthesis means and mild reaction conditions, and meets the development requirement of green chemistry.

Description

technical field [0001] The invention belongs to the technical fields of medicine, materials, cell biology, etc., and specifically relates to the one-step construction of 2-(2-furyl)-1,3,4- Oxadiazole method. Background technique [0002] 1,3,4-Oxadiazole and its derivatives are a class of important physiologically active substances, which have certain anti-inflammatory, antibacterial, anti-cancer, anti-AIDS and regulating plant growth activities. Some 1,3,4-oxadiazoles Oxadiazole compounds are also important photosensitive substances with optical activity and can be used as photosensitive polymer materials in electroluminescent instruments. The already marketed antihypertensive drugs thiodazosin and nesadil both contain the structural unit of 1,3,4-oxadiazole. Therefore, the synthesis of 1,3,4-oxadiazole compounds has always been a research hotspot for chemists. Its traditional synthesis methods often use toxic chemical reagents, such as phosphorus oxychloride. The prese...

Claims

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Application Information

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IPC IPC(8): C07D413/04
CPCC07D413/04
Inventor 及方华王守才蒋光彬
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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