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Use of rhein in preparation of drugs for prevention and treatment of hepatic encephalopathy

A technology of hepatic encephalopathy and rhein, which is applied in the field of medicine and achieves the effects of good prospect of development and use, alleviating inflammation and protecting liver function.

Inactive Publication Date: 2019-01-18
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the use of rhein as the only active ingredient in the prevention and treatment of hepatic encephalopathy has not been reported

Method used

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  • Use of rhein in preparation of drugs for prevention and treatment of hepatic encephalopathy
  • Use of rhein in preparation of drugs for prevention and treatment of hepatic encephalopathy
  • Use of rhein in preparation of drugs for prevention and treatment of hepatic encephalopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 TAA-induced rat hepatic encephalopathy model proves that rhein can significantly prevent and treat the progression and formation of hepatic encephalopathy.

[0039] 1 Materials and methods

[0040] 1.1 Experimental animals

[0041] Thirty Wistar male rats, SPF grade, body weight (200±20) g, were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine. Animal license number: SYXK (Shanghai 2014-008). The animals were raised, modeled and observed in the animal center, with free access to food and water.

[0042] 1.2 Drugs and reagents

[0043]TAA (China Pharmaceutical Group Shanghai Chemical Reagent Company, product batch number: 20160930), rhein (produced by Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd., product batch number: 140930), blood ammonia kit, serum TBil, ALT, AST, total bile Acid (TBA), total protein (TP), Alb detection kit and HE kit were purchased from Nanjing Jiancheng Institute of Bi...

Embodiment 2

[0061] Example 2 CCL 4 The induced rat model of hepatic encephalopathy confirmed that rhein can significantly prevent the progression and formation of hepatic encephalopathy.

[0062] 1 Materials and methods

[0063] 1.1 Animals

[0064] Thirty Wistar male rats, SPF grade, body weight (200±20) g, were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine. Animal license number: SYXK (Shanghai 2014-008). The animals were raised, modeled and observed in the animal center, with free access to food and water.

[0065] 1.2 Drugs and reagents

[0066] CCL 4 (China Pharmaceutical Group Shanghai Chemical Reagent Company, product batch number: 20170713), rhein (produced by Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd., product batch number: 140930), blood ammonia kit, serum TBil, ALT, AST, total bile acid (TBA), total protein (TP), Alb detection kit and HE, Sirius red staining kit were purchased from Nanjing Jiancheng ...

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Abstract

The invention relates to the technical field of medicine, in particular to the use of rhein in the preparation of drugs for prevention and treatment of hepatic encephalopathy. The application of rheinin the preparation of drugs for preventing and treating hepatic encephalopathy is disclosed for the first time. The model of hepatic encephalopathy induced by thioacetamide (TAA) and carbon tetrachloride (CCL4) was tested repeatedly. The results showed that rhein could reduce blood ammonia, alleviate inflammation of liver and brain tissue, protect liver function, reduce liver necrosis and improveliver injury and brain injury. Therefore, rhein or its salts can be used to prepare drugs for the prevention and treatment of hepatic encephalopathy. Rhein or its salts can be used as active ingredients to prevent and cure hepatic encephalopathy, which has the advantages of obvious effect, less dosage and quick onset.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of rhein in the preparation of medicines for preventing and treating hepatic encephalopathy. Background technique [0002] Hepatic encephalopathy (hepatic encephalopathy, HE) is one of the most serious complications of portal hypertension and cirrhosis. %the following. According to reports, the incidence of minimal hepatic encephalopathy (MHE) in patients with chronic liver disease is as high as 50%, and more than 50% of patients with MHE will convert to overt hepatic encephalopathy within 30 months. At the same time, hepatic encephalopathy also increases the patient's hospital stay, readmission rate and risk of death, causing a great economic burden on the family and society. The clinical treatment of hepatic encephalopathy is mainly to reduce ammonia and regulate the intestinal flora. At present, there are no effective prevention and treatment measures. Moder...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P1/16A61P25/00
CPCA61K31/192A61P1/16A61P25/00
Inventor 孙明瑜陆璐边艳琴武超曹红燕李建缘谢咚王铮
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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