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Application of retinoic acid in preparation of drugs for improving prognosis of cryptorchidism

A technology of retinoic acid and cryptorchidism, applied in the field of medicine, can solve the problems of inability to effectively improve children with cryptorchidism, safety and ethical issues, and achieve the effects of improving treatment strategies, improving spermatogenic function, and improving prognosis.

Inactive Publication Date: 2019-01-18
CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The measures taken in the current clinical treatment can only improve the position of the testis in patients with cryptorchidism and prevent the progression of lesions, but they cannot effectively improve the clinical prognosis of children with cryptorchidism, especially the reproductive function of children with bilateral cryptorchidism
With the progress of cell biology and tissue engineering research, some animal studies have found that stem cell therapy or testicular tissue transplantation can be used to treat cryptorchidism, but these treatments have safety and ethical issues to be resolved

Method used

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  • Application of retinoic acid in preparation of drugs for improving prognosis of cryptorchidism
  • Application of retinoic acid in preparation of drugs for improving prognosis of cryptorchidism
  • Application of retinoic acid in preparation of drugs for improving prognosis of cryptorchidism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Taking SPF grade SD rats as the experimental objects, exploring the effect of RA on the spermatogenic function of cryptorchid rats

[0026] (1) Experimental animal grouping and drug treatment

[0027] After one week of adaptive feeding, the female and male mice were caged together according to the ratio of female to male at 1:1, and the cage was regularly checked at 8 o'clock every morning to see if there was any vaginal plug. If there was, it was recorded as pregnancy 0d; The male and female mice were separated during the day and caged again at 16:00 in the afternoon.

[0028] After the 30 female mice were conceived, they were randomly divided into three groups, 10 in each group, and all were raised normally. The first group is the control group, after disinfection of the skin on the back of the neck at 8 o'clock in the morning on the 12th to 20th day of pregnancy, subcutaneous injection of 1 mg / mL corn oil 25 mg / kg / d; the second group is the Flu cryptorchidism group,...

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Abstract

The invention relates to the application of retinoic acid in preparation of drugs for improving prognosis of cryptorchidism, and belongs to the technical field of medicine. The drug is mainly composedof retinoic acid, which can improve the infertility of cryptorchidism patients, and can improve the spermatogenesis function of cryptorchidism patients by improving the oxidative stress level and apoptosis level of cryptorchidism patients' testis tissue and the expression level of blood-testis barrier-associated protein. This provides a basis for improving the clinical treatment strategy for cryptorchidism and improving the prognosis of cryptorchidism.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of retinoic acid in the preparation of drugs for improving the prognosis of patients with cryptorchidism. Background technique [0002] Cryptorchidism is one of the most common congenital malformations in male children. It usually shows that one or both testicles cannot descend into the scrotum for a long time. The incidence rate of general newborns is 2%-5%. With the increased risk of environmental factors and biological exposure during pregnancy and after birth, the incidence of cryptorchidism in children tends to increase gradually. In recent years, foreign surveys have found that the incidence of adult azoospermia in children with unilateral cryptorchidism is about 13%; in children with untreated bilateral cryptorchidism, the incidence of azoospermia is as high as 89%. The measures taken in current clinical treatment can only improve the position...

Claims

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Application Information

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IPC IPC(8): A61K31/203A61P15/08
CPCA61K31/203A61P15/08
Inventor 张德迎周宇何大维魏光辉
Owner CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV
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