Antirespiratory syncytial virus medicine suitable for cardiovascular disease patients
A syncytial virus and antiviral technology, applied in the field of medicine, can solve problems such as myocardial damage and inability to use ribavirin, and achieve the effects of enhanced inhibitory effect, easy production and promotion, and strong practicability
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[0027] Example 1 Preparation of derivatives
[0028] In a single-neck flask, mix the substituted phenylacetic acid (0.01mol), substituted benzaldehyde (0.01mol), 6.0mL of acetic anhydride (new distillation) and 0.7mL of triethylamine (new distillation), and electric heating at 130~140℃ React under reflux in the bag for 4-6 hours, cool to 100°C, add 1-2mL of distilled water to decompose, and stir for 5 minutes. Remove the reactants from the electric heating bag, cool to room temperature, put into 60mL of water, leave at room temperature to precipitate solids, filter A solid product is obtained.
[0029] For the solid product in the previous step, if NaOH solution is added, adjust the pH to about 12, stir the reaction at 90°C for 2 hours, cool to room temperature, adjust the pH to 6-7 with a dilute HCl solution, precipitate a white solid, filter to obtain the product , The E-configuration derivatives A1, A4, A5 and A6 with phenolic hydroxyl groups can be prepared. The prepared deri...
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[0042] Example 2 Biological test
[0043] 1. Screening of antiviral activity
[0044] The antiviral effects of ferulic acid derivatives in vitro, the common respiratory syncytial virus (RSV), herpes simplex virus type 1 (HSV-1), enterovirus 71 (EV71) and other antiviral effects research, reference ( Yue Lulu et al., World Traditional Chinese Medicine, 2018,13(01):199-206) method, observe cell survival rate under a microscope. This part of the content was tested by the Shandong Anti-Virus Research Center.
[0045] The ferulic acid (FA) and its derivatives (A1~A6) are formulated into the test solution. The experiment was divided into cell control group, virus control group and drug group, with ribavirin as the reference. Each group has 3 repeating holes. In the drug group, the ferulic acid derivative was diluted with cell maintenance solution, starting from 1:2, and then added to the cultured monolayer human laryngeal carcinoma cell (Hep2) or rhesus monkey embryonic kidney cell (MA...
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[0065] Example 3 Preparation of pharmaceutical composition
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