Chitosan ointment for preventing and treating radiation skin reaction and preparation process thereof

A technology of radioactive skin and preparation process, applied in the field of chitosan cream, can solve the problems of delayed treatment time, insignificant effect, interruption of treatment, etc., so as to alleviate the pain of patients, reduce local tissue lesions, and promote humoral immunity and cellular immunity. Effect

Inactive Publication Date: 2019-02-05
山东贝诺医药生物科技有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few drugs specially used for the prevention and treatment of radiation skin reactions clinically, and the drug prevention for the treatment of skin diseases is mostly used clinically, such as hormones, vitamins, traditional Chinese medicine and other external ointments, but these drugs are effective in prevention and treatment. The effect of radioactive skin is not obvious, and symptomatic treatment such as stopping radiotherapy, rest and anti-inflammatory treatment is often used to interrupt the treatment, thereby delaying the treatment time and affecting the curative effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chitosan ointment for preventing and treating radiation skin reaction and preparation process thereof
  • Chitosan ointment for preventing and treating radiation skin reaction and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] According to the production of 1000g cream, chitosan: 30g, Tween-80: 60g, glycerin: 130g, ethylparaben: 0.9g, white petrolatum: 30g, cetyl alcohol: 150g, glyceryl monostearate : 40g, the balance is sterile water for injection.

[0028] Prepare as follows:

[0029] (1) Preparation of the aqueous phase: under stirring, first add an appropriate amount of sterile water for injection to the chitosan to fully swell, then add glycerin, ethylparaben, and Tween-80 to the above chitosan aqueous solution, and heat to Standby at 70°C;

[0030] (2) Preparation of the oil phase: under stirring, heat the white petrolatum, cetyl alcohol, and glyceryl monostearate in the formula to 80°C for later use;

[0031] (3) Heat the jacketed pot of the homogeneous emulsifier to 70°C, first suck the oil phase into the jacketed pot of the homogeneous emulsifier, turn on the homogeneous emulsifier, and then suck the water phase into the jacketed pot of the homogeneous emulsifier, while Emulsify w...

Embodiment 2

[0033] According to the production of 1000g cream, chitosan: 50g, Tween-80: 80g, glycerin: 110g, ethylparaben: 1g, white vaseline: 100g, cetyl alcohol: 50g, glyceryl monostearate: 50g, and the balance is sterile water for injection.

[0034] Prepare as follows:

[0035] (1) Preparation of the aqueous phase: under stirring, first add an appropriate amount of sterile water for injection to the chitosan to fully swell, then add glycerin, ethylparaben, and Tween-80 to the above chitosan aqueous solution, and heat to Standby at 80°C;

[0036] (2) Preparation of the oil phase: under stirring, heat the white petrolatum, cetyl alcohol, and glyceryl monostearate in the formula to 75°C for later use;

[0037] (3) Heat the jacketed pot of the homogeneous emulsifier to 65°C, first suck the oil phase into the jacketed pot of the homogeneous emulsifier, turn on the homogeneous emulsifier, and then suck the water phase into the jacketed pot of the homogeneous emulsifier, while Emulsify wh...

Embodiment 3

[0039] According to the production of 1000g cream, chitosan: 10g, Tween-80: 40g, glycerin: 120g, ethylparaben: 0.95g, white petrolatum: 130g, cetyl alcohol: 90g, glyceryl monostearate : 30g, the balance is sterile water for injection.

[0040] Prepare as follows:

[0041] (1) Preparation of the aqueous phase: under stirring, first add an appropriate amount of sterile water for injection to the chitosan to fully swell, then add glycerin, ethylparaben, and Tween-80 to the above chitosan aqueous solution, and heat to Standby at 75°C;

[0042] (2) Preparation of the oil phase: under stirring, heat the white petrolatum, cetyl alcohol, and glyceryl monostearate in the formula to 70°C for later use;

[0043] (3) Heat the jacketed pot of the homogeneous emulsifier to 75°C, first suck the oil phase into the jacketed pot of the homogeneous emulsifier, turn on the homogeneous emulsifier, and then suck the water phase into the jacketed pot of the homogeneous emulsifier, while Emulsify ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses chitosan ointment for preventing and treating radiation skin reaction and a preparation process thereof. The chitosan ointment consists of the following components: 0.5 to 5 parts of chitosan, 3 to 13 parts of albolene, 5 to 15 parts of hexadecanol, 11 to 13 parts of glycerinum, 3 to 5 parts of glycerin monostearate, 4 to 8 parts of tween-80, 0.09 to 0.11 part of ethylparaben, and water for sterilization injection. The preparation process comprises the following steps: adding the chitosan, the glycerinum, the ethylparaben and the tween-80 into the water for sterilization injection, heating to 70 to 80 DEG C to prepare a water phase; heating the albolene, the hexadecanol and the glycerin monostearate to 70 to 80 DEG C to obtaine an oil phase; and heating a homogenizing emulsification machine jacketed pot to 65 to 75 DEG C, pumping the oil phase into the homogenizing emulsification machine jacketed pot, starting a homogenizing emulsifier, sucking the water phase into the homogenizing emulsification machine jacketed pot, sucking while emulsifying, emulsifying for 30 to 50 minutes after the water phase is completely sucked, cooling to 50 DEG C or below, thus obtaining the chitosan ointment. By adopting the chitosan ointment, the harm of the radiation skin disease caused by the radiotherapy to the patient can be effectively solved.

Description

technical field [0001] The invention relates to a chitosan cream for preventing and treating radiation skin reaction of patients undergoing radiotherapy and a preparation process thereof. Background technique [0002] Radiotherapy is one of the main treatment methods for malignant tumors. With the increase of the dose of radiotherapy, the skin of the patient's irradiated field will have more or less mild or severe radioactive reactions. The pathogenesis is that the DNA of the nucleus absorbs radiation energy, resulting in reversible or irreversible DNA synthesis and differentiation, which causes a series of skin reactions and damage caused by changes in cell genes. The severity of the damage is related to the nature and amount of radiation and the individual differences of patients. Generally speaking, when the radiation acts on the human body to reach a certain amount, it will cause disease. Studies have shown that erythema can be formed when the skin is exposed to 5GY, e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/722A61K47/10A61K47/26A61K47/14A61K47/06A61P17/16A61P35/00
CPCA61K9/0014A61K9/06A61K31/722A61K47/06A61K47/10A61K47/14A61K47/26A61P17/16A61P35/00
Inventor 惠培业禹志霞李攸容刘维峰
Owner 山东贝诺医药生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap