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Method for separating and extracting cannabidiol from industrial cannabis plants

A technology of industrial hemp and cannabidiol, applied in the field of natural medicinal chemistry, can solve the problems of difficulty in accurately controlling the polarity change of the eluent, complicated operation, etc., and achieve the effects of short cycle, simple operation and high extraction efficiency

Inactive Publication Date: 2019-02-22
YUNNAN MINZU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of this, the present invention provides a method for separating and extracting cannabidiol from industrial hemp plants, aiming at the problem that the operation of the existing separation and extraction technology is relatively complicated, and it is difficult to accurately control the polarity change of the eluent during the separation process.

Method used

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  • Method for separating and extracting cannabidiol from industrial cannabis plants
  • Method for separating and extracting cannabidiol from industrial cannabis plants
  • Method for separating and extracting cannabidiol from industrial cannabis plants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Follow the steps below to isolate and extract cannabidiol from industrial hemp plants:

[0044] 1.1 Plant extraction and concentration

[0045] Take by weighing 3700g the industrial hemp (moisture<5wt%) that contains stem, leaf and seed, pulverize through pulverizer, sample powder crosses 80 mesh sieves and sieves, the industrial hemp sample powder with the 95% ethanol / water solution of weight ratio 2 times amount Soaking, ultrasonic hot-dipping extraction, water bath temperature 47°C, ultrasonic power 200W, a total of 4 extractions, 8 hours each time; filter, combine extracts, water bath decompression concentration to evaporate ethanol / water solution, water bath temperature 55°C, vacuum pressure 0.07MPa, obtain 550g sample extract a.

[0046] 1.2 Extraction

[0047]The 550g sample extract a obtained in the above step 1.1 is fully stirred with purified water with a weight ratio of 1 times to a suspension state, and then the suspended sample liquid is extracted with pe...

Embodiment 2

[0054] Follow the steps below to isolate and extract cannabidiol from industrial hemp plants:

[0055] 1.1 Plant extraction and concentration

[0056] Weigh 3700g of industrial hemp containing stems, leaves and seeds (moisture<5wt%), pulverize through a pulverizer, and sieve the sample powder through an 80-mesh sieve, soak the industrial hemp sample powder with 95% aqueous ethanol solution with a weight ratio of 2.5 times , ultrasonic hot dip extraction, water bath temperature 50°C, ultrasonic power 275W, a total of 5 extractions, 8 hours each time; filter and combine the extracts, water bath decompression concentration to evaporate ethanol aqueous solution, water bath temperature 53°C, vacuum pressure 0.08 MPa, obtain 554g sample extract a.

[0057] 1.2 Extraction

[0058] The 554g sample extract a obtained in the above step 1.1 is fully stirred with purified water of 1.5 times the weight ratio until suspended, and then the suspended sample liquid is extracted with petroleu...

Embodiment 3

[0065] Follow the steps below to isolate and extract cannabidiol from industrial hemp plants:

[0066] 1.1 Plant extraction and concentration

[0067] Take by weighing 3700g the industrial hemp (moisture<5wt%) that contains stem, leaf and seed, pulverize through pulverizer, sample powder is sieved through 80 mesh sieves, industrial hemp sample powder is 95% ethanol / water solution with weight ratio 3 times amount Soaking, ultrasonic hot-dip extraction, water bath temperature 53°C, ultrasonic power 300W, a total of 6 extractions, 8 hours each time; filter, combine extracts, water bath decompression concentration to evaporate ethanol / water solution, water bath temperature 58°C, vacuum pressure It is 0.06MPa, obtains 558g sample extract a.

[0068] 1.2 Extraction

[0069] The 558g sample extract a obtained in the above step 1.1 is fully stirred with purified water with a weight ratio of 2 times to a suspended state, and then the suspended sample liquid is extracted with petroleu...

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Abstract

The invention discloses a method for separating and extracting cannabidiol from industrial cannabis plants. The method comprises the following steps: leaching and concentration of the plants, extraction, normal phase column chromatography, and reverse phase column chromatography. The method has the following advantages of determining the polarity based on the chemical structure characteristic of cannabidiol, selecting suitable extraction solvents according to the principle that like dissolves like, and carrying out two times of simple column chromatography isolation on extract which is obtained through extraction, thereby obtaining a required product. The separation process is simple, the cycle time is short, the number of varieties of the solvents used for formulating the polarity is small, the solvents are easy to purchase, and the solvents in the steps of extraction, column chromatography and the like can be recycled and reused, so that the solvent consumption is low and the cost isgreatly reduced. The cannabidiol separated out does not need to be repurified by high-cost and high-efficiency preparative liquid chromatography. The method has high extraction efficiency, and is convenient to implement, economical, rapid and simple in operation.

Description

technical field [0001] The invention belongs to the technical field of natural medicinal chemistry, and in particular relates to a method for separating and extracting cannabidiol from industrial hemp plants. Background technique [0002] The economic and medicinal value of hemp is extremely high. The raw material hemp exclusively for industrial use is referred to as "industrial hemp". The content of tetrahydrocannabinol (THC) in the flowers and leaves of hemp during the growth period is less than 3 / 1000. The value of extracting the toxic component tetrahydrocannabinol or taking it directly as a drug can be legally carried out in large-scale cultivation and industrial development and utilization. [0003] Industrial hemp (HEMP) has extremely high medicinal value and is widely used in textiles, paper, food, medicine, hygiene, daily chemicals, leather, automobiles, construction, decoration, packaging and other fields. It is a classic means of production, and also one of the t...

Claims

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Application Information

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IPC IPC(8): C07C39/17C07C37/82C07C37/72
CPCC07C37/72C07C37/82C07C2601/16C07C39/17
Inventor 李干鹏牟林云马恩广魏敏吴海燕郑晓晖
Owner YUNNAN MINZU UNIV
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