Drug for improving function of aortic endothelial cells and application thereof

Abstract

The invention belongs to the technical field of drugs and particularly relates to a drug for improving the function of aortic endothelial cells and application thereof. The drug has the beneficial effects that the inflammatory response of human aortic endothelial cells caused by saturated fatty acid can be obviously inhibited and the mitochondrial respiration and metabolism of vascular endothelialcells can be obviously enhanced; the occurrence and development of atherosclerosis can be prevented by resisting inflammation and protecting the mitochondrial function; the inflammatory response of human aortic endothelium caused by saturated fatty acid can be effectively reduced, such as mRNA level content of interleukin-6(IL-6) and matrix metalloproteinase-1(MMP-1); the saturated fatty acid canbe effectively prevented from damaging the mitochondrial function of the human aortic endothelial cells, such as increase of expression of mitochondrial complex I and III proteins and mitochondrial-metabolism-related Foxol protein and the like; the drug has good application prospect in preventing occurrence and progression of vascular diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for improving the function of aortic endothelial cells and an application thereof. Background technique [0002] Data show that 17,700 people die of cardiovascular disease every year in the world, accounting for 31% of the death toll. The rate is significantly higher than other diseases, in a leading position. Cardiovascular diseases mainly include cardiovascular and cerebrovascular diseases, such as myocardial infarction and cerebral infarction. Atherosclerosis is the pathological basis of cardiovascular diseases. [0003] The pathogenesis of atherosclerosis is very complex. It occurs in the vessel wall and is a chronic inflammatory response, plaque formation, and vascular endothelial cell damage. Factors leading to atherosclerosis mainly include unhealthy diets such as high salt, high fat, high energy, and smoking, as well as metabolic risk factors, i...

AI Technical Summary

Problems solved by technology

[0004] At present, atherosclerosis has drugs, surgery and other treatment methods, but this type of disease is highly occult, and has a high rate of death and disability, so early prevention is particularly important. Studies have reported that natural active ingredients such as chlorogenic acid, Paeoniae alba and lignans have anti-atherosclerosis functions, and functional foods based on them have come out one after another

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