D-shaped micro-column mirror rotary SPR (surface plasmon resonance) sensing chip

A sensor chip and mirror rotation technology, which is applied to measuring devices, instruments, and material analysis through optical means, can solve problems such as high cost, large instrument volume, and inconvenient replacement of sensing structures, and achieve low cost and real The effect of high-resolution modulation

Inactive Publication Date: 2019-03-19
GUILIN UNIV OF ELECTRONIC TECH
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Currently commercialized SPR sensors on the market still have some deficiencies, such as large instrument volume, high cost, inability to identify molecules and limited detection of small molecule concentrations, and inconvenient replacement of sensing structures in the sensing system. Therefore, people are urgently seeking More commercially valuable SPR sensors
[0003] In 2005, Soame Banerji of Arizona State University in the United States published an article in the international journal OpticsLetters, pointing out that a sensor with an optical fiber-based SPR dual sensing channel can achieve high-sensitivity measurements, but the SPR sensing device needs to be plated A polymer layer with a thickness of strictly 100nm is plated on the sensing area of ​​the gold film, so the processing technology and sensing structure are relatively complicated.
This method has a certain novelty, but there is no new improvement in the sensor structure, and it is not convenient to replace the chip of the sensing detection system

Method used

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  • D-shaped micro-column mirror rotary SPR (surface plasmon resonance) sensing chip
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  • D-shaped micro-column mirror rotary SPR (surface plasmon resonance) sensing chip

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Experimental program
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Effect test

Embodiment 1

[0041] Embodiment 1: Preparation of D-shaped microcylindrical lens rotating SPR sensor chip

[0042] Such as figure 2 and image 3 Shown, the preparation method of a kind of D-shaped microcylindrical mirror rotating SPR sensor chip is as follows:

[0043] First prepare the D-shaped micro-cylindrical lens optical substrate: heat-melt the preformed rod to make a D-shaped quartz or glass micro-rod, then use polishing technology to polish the side of the D-shaped quartz or glass micro-rod, and then make the D-shaped micro-rod Quartz or glass microrods are cut into appropriate lengths to obtain D-shaped microcylindrical lens optical substrates.

[0044] Then prepare a nano-metal film on the end face of the D-shaped micro-cylindrical optical substrate, taking the gold film as an example: a gold film with a thickness of about 50 nm is plated on the end face of the D-shaped micro-cylindrical optical substrate by sputtering. Of course, the gold film can also be prepared according t...

Embodiment 2

[0047] Embodiment 2: Simulation test of D-shaped microcylindrical lens rotating SPR sensor chip

[0048] Figure 6 It is a graph of the relationship between the horizontal rotation angle of the rotating platform and the incident angle of excitation light obtained through simulation calculation. In this simulation, the initial incident angle of the excitation light wave on the surface of the gold film is set to 72°, and as the horizontal direction of the rotating platform rotates every 0.01°, the incident angle changes accordingly. According to the simulation test, the rotation angle of the rotating platform has a good linearity in the change of the excitation angle in the range of 30°-60°, and the change of the resonance angle can reach 0.001° for every 0.01° rotation of the rotating platform. Therefore, the resonance angle measurement accuracy of the indirect angle modulation method is 10 times higher than that of the traditional direct angle modulation method.

[0049] F...

Embodiment 3

[0051] Embodiment 3: Application test of D-shaped microcylindrical lens rotating SPR sensor chip

[0052] The prepared D-shaped microcylindrical rotating SPR sensor chip can be directly connected to the sensor system for testing the liquid to be tested. Such as figure 1 As shown, the He-Ne laser 1 with a central wavelength of 632.8nm generates an optical signal, which is input to the polarization controller 2 by a single-mode fiber to control the output to become P-polarized light, and the P-polarized light is incident on the D-shaped micro-cylindrical rotating SPR The sensor chip 3 adjusts the incident angle of the incident light so that the light coincides with the radius of the D-shaped micro-lens optical substrate 31 . As the rotary platform 4 on which the D-shaped microcylindrical lens rotating SPR sensor chip 3 is placed rotates horizontally forward or horizontally in reverse, the incident angle of the incident light wave changes accordingly. When the incident angle rea...

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Abstract

The invention provides a D-shaped micro-column mirror rotary SPR (surface plasmon resonance) sensing chip, belongs to the field of optical sensing and the field of material engineering and particularly relates to the fields of pharmaceutical research and development, disease control, food safety and the like. The D-shaped micro-column mirror rotary SPR sensing chip comprises a D-shaped micro-column mirror optical substrate, a nano-metal film, a resonant enhancement film and a base. The modulation mode of the sensing chip includes that the chip is fixed onto a rotary platform, the rotary platform is turned along a center shaft perpendicular to the plane of the D-shaped micro-column mirror optical substrate, the incidence angle of incident light of the chip is changed, and high-resolution modulation of the incidence angle of exciting light generating SPR is realized. The chip has the advantages of low cost, miniaturization, easiness in integration, capability of realizing scale production, easiness in replacement of a sensing system chip and the like, and overcomes the shortcomings of operation complexity, high cost and the like of a traditional SPR detection technology. Compared with a traditional angle modulation mode, the modulation mode of the chip can improve SPR resonance angle measurement accuracy by several times.

Description

(1) Technical field [0001] The invention provides a D-shaped microcylindrical rotating SPR sensor chip, which belongs to the field of optical sensing and material engineering, and specifically relates to the fields of drug research and development, disease control, food safety and the like. (2) Background technology [0002] With the improvement of living standards, issues such as drug research and development, disease control and food safety have become the focus of global attention. In recent years, optical biosensing technology has been widely used in the above fields because of its high sensitivity, real-time, fast and flexible detection methods, but only surface plasmon resonance (SPR) has been commercialized in the field of biomolecular detection. Plasmon Resonance, SPR) technology. Currently commercialized SPR sensors on the market still have some deficiencies, such as large instrument volume, high cost, inability to identify molecules and limited detection of small ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 苑立波韦柳夏冯程成杨宏艳
Owner GUILIN UNIV OF ELECTRONIC TECH
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