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Solid-liquid mixture capable of solidifying to form hydrogel in real time under temperature control and preparation method thereof

A solid-liquid mixture, hydrogel technology, applied in medical science, prosthesis, etc., can solve the problems of unfavorable flow molding, limited application, too fast reaction, etc., achieve good low toxicity, good biocompatibility, promote The effect of tissue damage repair

Inactive Publication Date: 2019-03-26
吴容思
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyvinyl alcohol aqueous solution and sodium tetraborate aqueous solution can react rapidly under neutral or alkaline conditions to form hydrogel, which can solve the problem that the above-mentioned hydrogel curing time is too long, but its reaction is too fast, which is not conducive to the formation of hydrogel before flow molding, which limits its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment 1 provides a solid-liquid mixture that can solidify into a hydrogel in real time under temperature control, including an acidic solution and vaseline microcapsule particles, and sodium carbonate particles are wrapped in the vaseline microcapsule particles. In terms of the total mass of the solid-liquid mixture solidified into a hydrogel in real time under temperature control, the mass fraction of the vaseline microcapsule particles is 0.5%, and the mass fraction of the acidic solution is 99.5%; the mass fraction of the sodium carbonate particles The total mass accounts for 5%-5.2% of the total mass of the vaseline microcapsule particles; the acidic solution includes a blend of 1 mass part of sodium tetraborate decahydrate and acetic acid and 9 mass parts of polyvinyl alcohol aqueous solution; The mass fraction of sodium tetraborate decahydrate in the blend solution of sodium tetraborate decahydrate and acetic acid is 2%, the molar concentration of said ac...

Embodiment 2

[0054] This embodiment 2 provides a solid-liquid mixture that can solidify into a hydrogel in real time under temperature control, including an acidic solution and paraffin microcapsule particles, and sodium carbonate particles are wrapped in the paraffin microcapsule particles. In terms of the total mass of the solid-liquid mixture solidified into a hydrogel in real time under temperature control, the mass fraction of the paraffin microcapsule particles is 12%, and the mass fraction of the acidic solution is 88%; The total mass accounts for 60%-75% of the total mass of the paraffin microcapsule particles; the acidic solution includes a blend of 3 parts by mass of sodium tetraborate decahydrate and acetic acid and 7 parts by mass of an aqueous solution of polyvinyl alcohol; The mass fraction of sodium tetraborate decahydrate in the blend solution of sodium tetraborate decahydrate and acetic acid is 20%, the molar concentration of the acetic acid is 1.5M; the mass fraction of po...

Embodiment 3

[0066] This embodiment 3 provides a solid-liquid mixture that can be solidified into a hydrogel in real time under temperature control, including an acidic solution and beeswax microcapsule particles, and sodium percarbonate particles are wrapped in the beeswax microcapsule particles. In terms of the total mass of the solid-liquid mixture that can solidify into a hydrogel in real time under temperature control, the mass fraction of the beeswax microcapsule particles is 1%, and the mass fraction of the acidic solution is 99%; the sodium percarbonate The total mass of the particles accounts for 20%-25% of the total mass of the beeswax microcapsule particles; the acidic solution includes 1 mass part of a blend of sodium tetraborate and acetic acid and 9 mass parts of polyvinyl alcohol aqueous solution; The mass fraction of sodium tetraborate decahydrate in the blend solution of sodium tetraborate decahydrate and acetic acid is 5%, the molar concentration of said acetic acid is 0.5...

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Abstract

The invention belongs to the technical field of hydrogel, aims at solving the problem of the prior art that the solidification time of hydrogel is hard to control, and provides a solid-liquid mixturecapable of solidifying to form hydrogel in real time under temperature control. The solid-liquid mixture contains an acid solution and hydrophobic micro-capsule particles dispersing in the acid solution, polyethylene and sodium tetraborate are dissolved in the acid solution, the hydrophobic micro-capsule particles are formed by a capsule forming material and alkaline solid particles wrapped in thecapsule forming material, and the melting temperature of the capsule forming material is between 30 DEG C and 70 DEG C. According to the invention, by utilizing the characteristic that polyethylene and sodium tetraborate is unlikely to generate gelation reaction under an acid condition while is rapid in gelation under an alkaline condition, the alkaline solid particles are wrapped in the hydrophobic micro-capsule particles; after a wound is full of the solid-liquid mixture, hydrophobic micro-capsules are promoted to be melted by heating so as to regulate pH by releasing alkaline solid particles; and finally polyethylene and sodium tetraborate generate a sol-gel reaction rapidly, so as to realize real-time accurate control on the gelation time.

Description

technical field [0001] The invention belongs to the technical field of hydrogels, and in particular relates to a solid-liquid mixture capable of solidifying into hydrogels in real time under temperature control and a preparation method thereof. Background technique [0002] Hydrogel is a general term for a class of gel-like polymer materials with a three-dimensional network structure and high water content. Because of its good viscoelasticity, strong plasticity and good biocompatibility, it has been applied in the fields of medical transplantation, biosensing, and controlled drug release. Hydrogel dressings have high water content, excellent water retention, and excellent tissue bonding strength, which can maintain a proper moist repair environment for large area burns, trauma, and wounds with skin and tissue defects caused by surgery , effectively relieve pain and accelerate wound healing. [0003] The formation and curing time of existing hydrogels are generally longer, ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08K9/10C08K3/26C08K3/38A61L27/52A61L27/54A61L27/16
CPCA61L27/16A61L27/52A61L27/54A61L2300/414C08J3/075C08J2329/04C08K9/10C08K2003/262C08K2003/387
Inventor 吴容思
Owner 吴容思