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Gentiopicroside and applications thereof

A technology of gentiopicroside and medicine is applied in the field of traditional Chinese medicine extracts for lowering blood sugar, which can solve the problem that the application of gentiopicroside has not yet been reported, and achieve the effects of improving renal function and renal tissue pathology, with good effect and reducing blood sugar.

Inactive Publication Date: 2019-03-29
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Previous studies have shown that gentiopicroside has pharmacological effects such as anti-inflammatory and analgesic, liver protection and choleretic, stomach invigorating, and blood pressure regulation, but the application of gentiopicroside in diabetes and diabetic chronic kidney disease has not been reported yet.

Method used

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  • Gentiopicroside and applications thereof
  • Gentiopicroside and applications thereof
  • Gentiopicroside and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 Index detection

[0045] (1) Detection of biochemical indicators such as blood sugar, blood lipids and renal function

[0046] Fasting blood glucose (FBG) was collected from the tail vein, and blood glucose was measured using a blood glucose meter (Johnson & Johnson, USA); serum total cholesterol (T-CHO) and serum triglyceride (TG) were measured by COD-PAP method (single reagent type) , GPO-PAP method (single reagent type); low-density cholesterol lipoprotein (LDL-C) and high-density cholesterol lipoprotein (HDL-C) are detected by enzyme colorimetry; Functional indicators were detected by sarcosine oxidase method, urease method, and CBB method, and the kits used for relevant detection were provided by Nanjing Jiancheng Bioengineering Research Institute.

[0047] (2) Detection of glycosylated serum protein and hemoglobin

[0048] Glycated serum protein (GSP) and glycosylated hemoglobin (HbA1c) were detected by fructosamine method and enzyme colorimetric me...

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Abstract

The present invention discloses an application of gentiopicroside to the preparation of medicines for lowering blood sugar and / or improving diabetic vascular complications, and an application of gentiopicroside to the preparation of medicines for reducing blood fat. The invention also discloses a method for extracting gentiopicroside. The invention proves that gentiopicroside can obviously reduceglycometabolism indexes such as blood sugar, glycosylated hemoglobin and serum protein of diabetic model mice, regulate the abnormality of blood fat and oxidative stress index of the model mice, and obviously improve the abnormality of renal function, renal tissue pathology and inflammatory fibrosis components of the model mice. Moreover, the gentiopicroside has good effect on improving LDL-C and24-hour urine protein. Consequently, the gentiopicroside is a traditional Chinese medicine monomer medicament which has the potential of reducing blood sugar and comprehensively improving diabetic nephropathy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract for lowering blood sugar, especially gentiopicroside and its application in the preparation of blood sugar lowering drugs. Background technique [0002] Diabetes is one of the diseases with the fastest-growing morbidity worldwide, and the third-highest mortality disease after cardiovascular diseases and tumors. The World Health Organization estimates that by 2030, the number of diabetic patients worldwide may exceed 360 million, of which 90% to 95% are type 2 diabetes. China is the second largest country with diabetes in the world. The "Prevalence of Diabetes in China's Population" released by the internationally authoritative journal "New England Journal of Medicine" in 2010 shows that the age-standardized incidence of diabetes in China is 9.7% (male 10.6%, female 8.8%) ; The incidence of diabetes increased with age, 20 to 39 years old, 40 to 59 years old and over 60 years old population...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P3/10A61P9/00A61P13/12A61P3/06C07H17/04C07H1/08
CPCA61K31/7048A61P3/06A61P3/10A61P9/00A61P13/12C07H1/08C07H17/04
Inventor 黄河清肖海明张萌
Owner SUN YAT SEN UNIV
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