Rabdosia serra formula granule used for treating acute jaundice hepatitis and preparation method thereof

A technology for formula granules and acute jaundice, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., to achieve the effects of easy storage, uniform particle size, and convenient implementation.

Inactive Publication Date: 2019-03-29
JIANGXI GROUNDIONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about Xihuangcao formula granules and its preparation process at present

Method used

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  • Rabdosia serra formula granule used for treating acute jaundice hepatitis and preparation method thereof
  • Rabdosia serra formula granule used for treating acute jaundice hepatitis and preparation method thereof

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preparation example Construction

[0021] The preparation method of Xihuangcao formula granule of the present invention comprises the following steps:

[0022] (1) pulverizing the dried Xihuang herbal medicinal material to obtain a powder with a particle size of 40-100 mesh;

[0023] (2) Soak the obtained powder in 2-5 times the volume of hot water;

[0024] (3) filter, the filter cake obtained is mixed with the aqueous ethanol solution of 15-20 times of feeding amount;

[0025] (4) ultrasonic extraction 2-3 times;

[0026] (5) filter, and the filtrate is concentrated under reduced pressure to a concentrated solution whose relative density is 1.05-1.15;

[0027] (6) mixing the concentrate with pharmaceutically acceptable adjuvants;

[0028] (7) Freeze-drying, collecting the dry cream powder, pulverizing through an 80-mesh sieve, and mixing in a mixing tank;

[0029] (8) The obtained Xihuangcao ointment was granulated, and the granules were sequentially sized through a 20-mesh sieve and a 50-mesh sieve to ob...

Embodiment 1

[0045] (1) Take 1 kg of dried Xihuang herb, crush it to 80 mesh, soak it in hot water (50°C) with 3 times the feeding amount for 2 hours, filter it with 200 mesh stainless steel wire mesh, and mix the obtained filter cake with 18 times the feeding amount Aqueous ethanol solution (concentration is 45%) is mixed, ultrasonically extracts 3 times under the ultrasonic frequency of 90kHz, extracts 45 minutes each time, filters with 200 order stainless steel screens, and the filtrate is concentrated under reduced pressure to the concentrated solution that relative density is 1.10;

[0046] (2) Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, crush it through an 80-mesh sieve, and mix it in a mixing tank ;

[0047] (3) Take Xihuangcao paste powder, sieve and granulate, and granulate the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain Xi...

Embodiment 2

[0049] (1) Take 1 kg of dried Xihuang herb, crush it to 100 mesh, add 4 times the amount of hot water (45°C) to soak for 3 hours, filter with 200 mesh stainless steel wire mesh, and mix the obtained filter cake with 16 times the amount of feed Aqueous ethanol solution (concentration is 40%) is mixed, ultrasonically extracts 3 times under the ultrasonic frequency of 90kHz, extracts 45 minutes each time, filters with 200 order stainless steel screens, and the filtrate is concentrated under reduced pressure to the concentrated solution that relative density is 1.12;

[0050] (2) Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, crush it through an 80-mesh sieve, and mix it in a mixing tank ;

[0051] (3) Take Xihuangcao paste powder, sieve and granulate, and granulate the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain Xihuangcao fo...

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Abstract

The present invention relates to the technical field of traditional Chinese medicine formula granules and discloses a rabdosia serra formula granule used for treating acute jaundice hepatitis and a preparation method thereof. The method comprises the following steps: (1) a dried rabdosia serra medicinal material is crushed; (2) obtained powder is soaked in hot water; (3) filtering is conducted: anobtained filter cake is mixed with an ethanol aqueous solution; (4) ultrasonic extraction is conducted for 2-3 times; (5) filtering is conducted and a filtrate is subjected to vacuum concentration; (6) a concentrate is mixed with pharmaceutically acceptable excipients; (7) freeze-drying is conducted, dry paste powder is collected, crushing and passing an 80 mesh sieve are conducted, and placing in a mixed tank for mixing is conducted; and (8) an obtained rabdosia serra paste is granulated and granule separating is conducted. The rabdosia serra formula granule prepared by using the method hasrelatively high active component content and a uniform granule size.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine formula granules, in particular to Xihuangcao formula granules for treating acute icteric hepatitis and a preparation method thereof. Background technique [0002] Traditional Chinese medicine formula granules are obtained by extracting, separating, concentrating, drying, granulating and packaging the whole ingredients of the medicinal materials through modern processing technology and pharmaceutical technology. They can be directly formulated and packaged without decoction. Granules for ingestion. Traditional Chinese medicine formula granules not only retain the active ingredients, indications and efficacy of traditional Chinese medicine decoction pieces, but also have the advantages that decoction pieces do not have, such as unified standard, stable curative effect, convenient carrying and easy adjustment. Over-the-counter supplements. [0003] Rabdosia serra (Maxim.) Hara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/16A61P1/16
CPCA61K9/1652A61K36/53A61K2236/15A61K2236/333A61K2236/51A61P1/16
Inventor 廖年生邹明明眭荣春曾照明
Owner JIANGXI GROUNDIONG PHARM CO LTD
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